Plasmodium chabaudi‐infected mice spleen response to synthesized silver nanoparticles from Indigofera oblongifolia extract
Malaria is a worldwide serious‐threatening infectious disease caused by Plasmodium and the parasite resistance to antimalarial drugs has confirmed a significant obstacle to novel therapeutic antimalarial drugs. In this article, we assessed the antioxidant and anti‐inflammatory activity of nanopartic...
Gespeichert in:
| Veröffentlicht in: | Letters in applied microbiology 2020-11, Vol.71 (5), p.542-549 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 549 |
|---|---|
| container_issue | 5 |
| container_start_page | 542 |
| container_title | Letters in applied microbiology |
| container_volume | 71 |
| creator | Al‐Quraishy, S. Murshed, M. Delic, D. Al‐Shaebi, E.M. Qasem, M.A.A. Mares, M.M. Dkhil, M.A. |
| description | Malaria is a worldwide serious‐threatening infectious disease caused by Plasmodium and the parasite resistance to antimalarial drugs has confirmed a significant obstacle to novel therapeutic antimalarial drugs. In this article, we assessed the antioxidant and anti‐inflammatory activity of nanoparticles prepared from Indigofera oblongifolia extract (AgNPs) against the infection with Plasmodium chabaudi caused in mice spleen. AgNPs could significantly suppress the parasitaemia caused by the parasite to approximately 98% on day 7 postinfection with P. chabaudi and could improve the histopathological induced spleen damage. Also, AgNPs were able to increase the capsule thickness of the infected mice spleen. In addition, the AgNPs functioned as an antioxidant agent that affects the change in glutathione, nitric oxide and catalase levels in the spleen. Moreover spleen IL1β, IL‐6 and TNF‐α‐mRNA expression was regulated by AgNPs administration to the infected mice. These results indicated the anti‐oxidant and the anti‐inflammatory protective role of AgNPs against P. chabaudi‐induced spleen injury.
Significance and Impact of the Study: Due to the resistance of the Plasmodium parasite to antimalarial drugs, only a few attempts have been made to use nanocarriers with the specific targeting approach in malaria treatment. In this article, we verified the antioxidant and anti‐inflammatory activity of silver nanoparticles prepared from Indigofera oblongifolia extract (AgNPs) against the Plasmodium chabaudi‐induced infection in mice spleen. Consequently, the findings obtained detect that AgNPs may be investigated as candidates of promise for therapeutic applications. In addition, our study offers important insights into the spleen response to infection as well as the promising use of AgNPs to combat P. chabaudi‐induced malaria. |
| doi_str_mv | 10.1111/lam.13366 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2450791934</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2450791934</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2686-126da5e53209565f90ae9ab90aa313d5d0948e0e9c961a55c50ea19eef0cd46b3</originalsourceid><addsrcrecordid>eNp1kM9OFTEUhxsCkQu44AVME1YuBvpn2nu7JESB5BpZaMJucqY9AyWddmxnhEtc-Ag-o0_i6EV3ns1v8-U7yUfIMWenfL6zAP0pl1LrHbLg9VJUS61ud8mCCa2rlVD1Pjko5YExtuLCvCL7Uixrw5hckG83AUqfnJ96au-hhcn5n99_-NihHdHR3lukZQiIkWYsQ4oF6Zho2cTxHot_npniw1fMNEJMA-TR24CFdjn19Do6f5c6zEBTG1K8810KHig-jRnseET2OggFX7_sIfn8_t2ni6tq_fHy-uJ8XVmhV7riQjtQqKRgRmnVGQZooJ0HJJdOOWbqFTI01mgOSlnFELhB7Jh1tW7lITnZeoecvkxYxuYhTTnOLxtRK7Y03Mh6pt5uKZtTKRm7Zsi-h7xpOGt-d27mzs2fzjP75sU4tT26f-TfsDNwtgUefcDN_03N-vzDVvkLe4KLFA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2450791934</pqid></control><display><type>article</type><title>Plasmodium chabaudi‐infected mice spleen response to synthesized silver nanoparticles from Indigofera oblongifolia extract</title><source>MEDLINE</source><source>Wiley Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Al‐Quraishy, S. ; Murshed, M. ; Delic, D. ; Al‐Shaebi, E.M. ; Qasem, M.A.A. ; Mares, M.M. ; Dkhil, M.A.</creator><creatorcontrib>Al‐Quraishy, S. ; Murshed, M. ; Delic, D. ; Al‐Shaebi, E.M. ; Qasem, M.A.A. ; Mares, M.M. ; Dkhil, M.A.</creatorcontrib><description>Malaria is a worldwide serious‐threatening infectious disease caused by Plasmodium and the parasite resistance to antimalarial drugs has confirmed a significant obstacle to novel therapeutic antimalarial drugs. In this article, we assessed the antioxidant and anti‐inflammatory activity of nanoparticles prepared from Indigofera oblongifolia extract (AgNPs) against the infection with Plasmodium chabaudi caused in mice spleen. AgNPs could significantly suppress the parasitaemia caused by the parasite to approximately 98% on day 7 postinfection with P. chabaudi and could improve the histopathological induced spleen damage. Also, AgNPs were able to increase the capsule thickness of the infected mice spleen. In addition, the AgNPs functioned as an antioxidant agent that affects the change in glutathione, nitric oxide and catalase levels in the spleen. Moreover spleen IL1β, IL‐6 and TNF‐α‐mRNA expression was regulated by AgNPs administration to the infected mice. These results indicated the anti‐oxidant and the anti‐inflammatory protective role of AgNPs against P. chabaudi‐induced spleen injury.
Significance and Impact of the Study: Due to the resistance of the Plasmodium parasite to antimalarial drugs, only a few attempts have been made to use nanocarriers with the specific targeting approach in malaria treatment. In this article, we verified the antioxidant and anti‐inflammatory activity of silver nanoparticles prepared from Indigofera oblongifolia extract (AgNPs) against the Plasmodium chabaudi‐induced infection in mice spleen. Consequently, the findings obtained detect that AgNPs may be investigated as candidates of promise for therapeutic applications. In addition, our study offers important insights into the spleen response to infection as well as the promising use of AgNPs to combat P. chabaudi‐induced malaria.</description><identifier>ISSN: 0266-8254</identifier><identifier>EISSN: 1472-765X</identifier><identifier>DOI: 10.1111/lam.13366</identifier><identifier>PMID: 32749003</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; Antimalarial agents ; antioxidant ; Antioxidants ; Antioxidants - pharmacology ; Catalase ; Catalase - metabolism ; cytokines ; Drug resistance ; Drugs ; Gene expression ; Glutathione ; Glutathione - metabolism ; Indigofera ; Indigofera - metabolism ; Infectious diseases ; Inflammation ; Interleukin 1 ; Interleukin-1beta - analysis ; Interleukin-6 - analysis ; Malaria ; Malaria - drug therapy ; Malaria - parasitology ; Malaria - pathology ; Male ; Metal Nanoparticles ; Mice ; Mice, Inbred C57BL ; Nanoparticles ; Nitric oxide ; Nitric Oxide - metabolism ; Oxidants ; Oxidizing agents ; Parasite resistance ; Parasitemia - drug therapy ; Parasitemia - pathology ; Plant Extracts - pharmacology ; Plasmodium chabaudi ; Plasmodium chabaudi - drug effects ; Reagents ; Silver ; Silver - pharmacology ; silver nanoparticles ; Spleen ; Spleen - parasitology ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - analysis ; Vector-borne diseases</subject><ispartof>Letters in applied microbiology, 2020-11, Vol.71 (5), p.542-549</ispartof><rights>2020 The Society for Applied Microbiology</rights><rights>2020 The Society for Applied Microbiology.</rights><rights>Copyright © 2020 The Society for Applied Microbiology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2686-126da5e53209565f90ae9ab90aa313d5d0948e0e9c961a55c50ea19eef0cd46b3</citedby><cites>FETCH-LOGICAL-c2686-126da5e53209565f90ae9ab90aa313d5d0948e0e9c961a55c50ea19eef0cd46b3</cites><orcidid>0000-0003-1869-5800</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Flam.13366$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Flam.13366$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32749003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al‐Quraishy, S.</creatorcontrib><creatorcontrib>Murshed, M.</creatorcontrib><creatorcontrib>Delic, D.</creatorcontrib><creatorcontrib>Al‐Shaebi, E.M.</creatorcontrib><creatorcontrib>Qasem, M.A.A.</creatorcontrib><creatorcontrib>Mares, M.M.</creatorcontrib><creatorcontrib>Dkhil, M.A.</creatorcontrib><title>Plasmodium chabaudi‐infected mice spleen response to synthesized silver nanoparticles from Indigofera oblongifolia extract</title><title>Letters in applied microbiology</title><addtitle>Lett Appl Microbiol</addtitle><description>Malaria is a worldwide serious‐threatening infectious disease caused by Plasmodium and the parasite resistance to antimalarial drugs has confirmed a significant obstacle to novel therapeutic antimalarial drugs. In this article, we assessed the antioxidant and anti‐inflammatory activity of nanoparticles prepared from Indigofera oblongifolia extract (AgNPs) against the infection with Plasmodium chabaudi caused in mice spleen. AgNPs could significantly suppress the parasitaemia caused by the parasite to approximately 98% on day 7 postinfection with P. chabaudi and could improve the histopathological induced spleen damage. Also, AgNPs were able to increase the capsule thickness of the infected mice spleen. In addition, the AgNPs functioned as an antioxidant agent that affects the change in glutathione, nitric oxide and catalase levels in the spleen. Moreover spleen IL1β, IL‐6 and TNF‐α‐mRNA expression was regulated by AgNPs administration to the infected mice. These results indicated the anti‐oxidant and the anti‐inflammatory protective role of AgNPs against P. chabaudi‐induced spleen injury.
Significance and Impact of the Study: Due to the resistance of the Plasmodium parasite to antimalarial drugs, only a few attempts have been made to use nanocarriers with the specific targeting approach in malaria treatment. In this article, we verified the antioxidant and anti‐inflammatory activity of silver nanoparticles prepared from Indigofera oblongifolia extract (AgNPs) against the Plasmodium chabaudi‐induced infection in mice spleen. Consequently, the findings obtained detect that AgNPs may be investigated as candidates of promise for therapeutic applications. In addition, our study offers important insights into the spleen response to infection as well as the promising use of AgNPs to combat P. chabaudi‐induced malaria.</description><subject>Animals</subject><subject>Antimalarial agents</subject><subject>antioxidant</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Catalase</subject><subject>Catalase - metabolism</subject><subject>cytokines</subject><subject>Drug resistance</subject><subject>Drugs</subject><subject>Gene expression</subject><subject>Glutathione</subject><subject>Glutathione - metabolism</subject><subject>Indigofera</subject><subject>Indigofera - metabolism</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Interleukin 1</subject><subject>Interleukin-1beta - analysis</subject><subject>Interleukin-6 - analysis</subject><subject>Malaria</subject><subject>Malaria - drug therapy</subject><subject>Malaria - parasitology</subject><subject>Malaria - pathology</subject><subject>Male</subject><subject>Metal Nanoparticles</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nanoparticles</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Oxidants</subject><subject>Oxidizing agents</subject><subject>Parasite resistance</subject><subject>Parasitemia - drug therapy</subject><subject>Parasitemia - pathology</subject><subject>Plant Extracts - pharmacology</subject><subject>Plasmodium chabaudi</subject><subject>Plasmodium chabaudi - drug effects</subject><subject>Reagents</subject><subject>Silver</subject><subject>Silver - pharmacology</subject><subject>silver nanoparticles</subject><subject>Spleen</subject><subject>Spleen - parasitology</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><subject>Vector-borne diseases</subject><issn>0266-8254</issn><issn>1472-765X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9OFTEUhxsCkQu44AVME1YuBvpn2nu7JESB5BpZaMJucqY9AyWddmxnhEtc-Ag-o0_i6EV3ns1v8-U7yUfIMWenfL6zAP0pl1LrHbLg9VJUS61ud8mCCa2rlVD1Pjko5YExtuLCvCL7Uixrw5hckG83AUqfnJ96au-hhcn5n99_-NihHdHR3lukZQiIkWYsQ4oF6Zho2cTxHot_npniw1fMNEJMA-TR24CFdjn19Do6f5c6zEBTG1K8810KHig-jRnseET2OggFX7_sIfn8_t2ni6tq_fHy-uJ8XVmhV7riQjtQqKRgRmnVGQZooJ0HJJdOOWbqFTI01mgOSlnFELhB7Jh1tW7lITnZeoecvkxYxuYhTTnOLxtRK7Y03Mh6pt5uKZtTKRm7Zsi-h7xpOGt-d27mzs2fzjP75sU4tT26f-TfsDNwtgUefcDN_03N-vzDVvkLe4KLFA</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Al‐Quraishy, S.</creator><creator>Murshed, M.</creator><creator>Delic, D.</creator><creator>Al‐Shaebi, E.M.</creator><creator>Qasem, M.A.A.</creator><creator>Mares, M.M.</creator><creator>Dkhil, M.A.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7ST</scope><scope>7T7</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0003-1869-5800</orcidid></search><sort><creationdate>202011</creationdate><title>Plasmodium chabaudi‐infected mice spleen response to synthesized silver nanoparticles from Indigofera oblongifolia extract</title><author>Al‐Quraishy, S. ; Murshed, M. ; Delic, D. ; Al‐Shaebi, E.M. ; Qasem, M.A.A. ; Mares, M.M. ; Dkhil, M.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2686-126da5e53209565f90ae9ab90aa313d5d0948e0e9c961a55c50ea19eef0cd46b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antimalarial agents</topic><topic>antioxidant</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Catalase</topic><topic>Catalase - metabolism</topic><topic>cytokines</topic><topic>Drug resistance</topic><topic>Drugs</topic><topic>Gene expression</topic><topic>Glutathione</topic><topic>Glutathione - metabolism</topic><topic>Indigofera</topic><topic>Indigofera - metabolism</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Interleukin 1</topic><topic>Interleukin-1beta - analysis</topic><topic>Interleukin-6 - analysis</topic><topic>Malaria</topic><topic>Malaria - drug therapy</topic><topic>Malaria - parasitology</topic><topic>Malaria - pathology</topic><topic>Male</topic><topic>Metal Nanoparticles</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nanoparticles</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Oxidants</topic><topic>Oxidizing agents</topic><topic>Parasite resistance</topic><topic>Parasitemia - drug therapy</topic><topic>Parasitemia - pathology</topic><topic>Plant Extracts - pharmacology</topic><topic>Plasmodium chabaudi</topic><topic>Plasmodium chabaudi - drug effects</topic><topic>Reagents</topic><topic>Silver</topic><topic>Silver - pharmacology</topic><topic>silver nanoparticles</topic><topic>Spleen</topic><topic>Spleen - parasitology</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><topic>Vector-borne diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al‐Quraishy, S.</creatorcontrib><creatorcontrib>Murshed, M.</creatorcontrib><creatorcontrib>Delic, D.</creatorcontrib><creatorcontrib>Al‐Shaebi, E.M.</creatorcontrib><creatorcontrib>Qasem, M.A.A.</creatorcontrib><creatorcontrib>Mares, M.M.</creatorcontrib><creatorcontrib>Dkhil, M.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Letters in applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al‐Quraishy, S.</au><au>Murshed, M.</au><au>Delic, D.</au><au>Al‐Shaebi, E.M.</au><au>Qasem, M.A.A.</au><au>Mares, M.M.</au><au>Dkhil, M.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasmodium chabaudi‐infected mice spleen response to synthesized silver nanoparticles from Indigofera oblongifolia extract</atitle><jtitle>Letters in applied microbiology</jtitle><addtitle>Lett Appl Microbiol</addtitle><date>2020-11</date><risdate>2020</risdate><volume>71</volume><issue>5</issue><spage>542</spage><epage>549</epage><pages>542-549</pages><issn>0266-8254</issn><eissn>1472-765X</eissn><abstract>Malaria is a worldwide serious‐threatening infectious disease caused by Plasmodium and the parasite resistance to antimalarial drugs has confirmed a significant obstacle to novel therapeutic antimalarial drugs. In this article, we assessed the antioxidant and anti‐inflammatory activity of nanoparticles prepared from Indigofera oblongifolia extract (AgNPs) against the infection with Plasmodium chabaudi caused in mice spleen. AgNPs could significantly suppress the parasitaemia caused by the parasite to approximately 98% on day 7 postinfection with P. chabaudi and could improve the histopathological induced spleen damage. Also, AgNPs were able to increase the capsule thickness of the infected mice spleen. In addition, the AgNPs functioned as an antioxidant agent that affects the change in glutathione, nitric oxide and catalase levels in the spleen. Moreover spleen IL1β, IL‐6 and TNF‐α‐mRNA expression was regulated by AgNPs administration to the infected mice. These results indicated the anti‐oxidant and the anti‐inflammatory protective role of AgNPs against P. chabaudi‐induced spleen injury.
Significance and Impact of the Study: Due to the resistance of the Plasmodium parasite to antimalarial drugs, only a few attempts have been made to use nanocarriers with the specific targeting approach in malaria treatment. In this article, we verified the antioxidant and anti‐inflammatory activity of silver nanoparticles prepared from Indigofera oblongifolia extract (AgNPs) against the Plasmodium chabaudi‐induced infection in mice spleen. Consequently, the findings obtained detect that AgNPs may be investigated as candidates of promise for therapeutic applications. In addition, our study offers important insights into the spleen response to infection as well as the promising use of AgNPs to combat P. chabaudi‐induced malaria.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>32749003</pmid><doi>10.1111/lam.13366</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1869-5800</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0266-8254 |
| ispartof | Letters in applied microbiology, 2020-11, Vol.71 (5), p.542-549 |
| issn | 0266-8254 1472-765X |
| language | eng |
| recordid | cdi_proquest_journals_2450791934 |
| source | MEDLINE; Wiley Journals; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Antimalarial agents antioxidant Antioxidants Antioxidants - pharmacology Catalase Catalase - metabolism cytokines Drug resistance Drugs Gene expression Glutathione Glutathione - metabolism Indigofera Indigofera - metabolism Infectious diseases Inflammation Interleukin 1 Interleukin-1beta - analysis Interleukin-6 - analysis Malaria Malaria - drug therapy Malaria - parasitology Malaria - pathology Male Metal Nanoparticles Mice Mice, Inbred C57BL Nanoparticles Nitric oxide Nitric Oxide - metabolism Oxidants Oxidizing agents Parasite resistance Parasitemia - drug therapy Parasitemia - pathology Plant Extracts - pharmacology Plasmodium chabaudi Plasmodium chabaudi - drug effects Reagents Silver Silver - pharmacology silver nanoparticles Spleen Spleen - parasitology Tumor necrosis factor Tumor Necrosis Factor-alpha - analysis Vector-borne diseases |
| title | Plasmodium chabaudi‐infected mice spleen response to synthesized silver nanoparticles from Indigofera oblongifolia extract |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T02%3A40%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasmodium%20chabaudi%E2%80%90infected%20mice%20spleen%20response%20to%20synthesized%20silver%20nanoparticles%20from%20Indigofera%20oblongifolia%20extract&rft.jtitle=Letters%20in%20applied%20microbiology&rft.au=Al%E2%80%90Quraishy,%20S.&rft.date=2020-11&rft.volume=71&rft.issue=5&rft.spage=542&rft.epage=549&rft.pages=542-549&rft.issn=0266-8254&rft.eissn=1472-765X&rft_id=info:doi/10.1111/lam.13366&rft_dat=%3Cproquest_cross%3E2450791934%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2450791934&rft_id=info:pmid/32749003&rfr_iscdi=true |