Green Biosynthesis of Silver Nanoparticles Using Vallarai Chooranam and Their Potential Biomedical Applications
The synthesis of silver nanoparticles was done using vallarai chooranam as a bio reducing agent and ascertained by UV–Visible spectrum at 432 nm. Fourier transform infra-red spectrum revealed that the proteins and other ligands were liable for the capping of synthesized silver nanoparticles (VC-AgNP...
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| Veröffentlicht in: | Journal of inorganic and organometallic polymers and materials 2020-11, Vol.30 (11), p.4709-4719 |
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| creator | Sathiyaraj, Sivaji Suriyakala, Gunasekaran Gandhi, Arumugam Dhanesh Saranya, Sivakumar Santhoshkumar, Murali Kavitha, Purushothaman Babujanarthanam, Ranganathan |
| description | The synthesis of silver nanoparticles was done using vallarai chooranam as a bio reducing agent and ascertained by UV–Visible spectrum at 432 nm. Fourier transform infra-red spectrum revealed that the proteins and other ligands were liable for the capping of synthesized silver nanoparticles (VC-AgNPs). Crystalline nature, spherical shapes particles with the size between 40 to 50 nm and elemental composition were found using X-ray Diffraction, Transmission Electron Microscopy and Energy-dispersive X-ray spectroscopy. By using Dynamic Light Scattering analysis, the average size of silver nanoparticles was found to be 43.1 nm and the zeta potential value was − 47.5 mV implying the stability of VC-AgNPs. The antibacterial activity of VC-AgNPs showed the maximum and minimum zone of inhibition towards
E. coli
(23 ± 0.69 mm) and
Bacillus subtilis
(12.67 ± 0.38 mm). The in vitro antioxidant study revealed the free radical scavenging activity of VC-AgNPs by 2,2-diphenyl-1-picrylhydrazyl and Nitric oxide at the inhibitory concentration (IC
50
) of 23.11 ± 2.05 µg/mL and 36.52 ± 2.37 µg/mL respectively. The anthelmintic efficacy of VC-AgNPs against
Pheretima posthumus
mortality was found to be 87% at 5 µg/cm
2
. VC-AgNPs showed significant larvicidal activity against
Culex quinquefasciatus
with a lethal dose of 0.788 ppm and also VC-AgNPs significantly inhibited the production of acetylcholinesterase with the IC
50
value of 0.875 ppm. VC-AgNPs displayed remarkable cytotoxicity against the lung cancer cell line A549 in a dose dependent way with the IC
50
value of 125 µg/mL. We demonstrated that VC-AgNPs can be further exploited as a potential candidate for antibacterial, antioxidant, anthelmintic, larvicidal, anti-acetylcholinesterase and anticancer activity.
Graphic Abstract |
| doi_str_mv | 10.1007/s10904-020-01683-7 |
| format | Article |
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E. coli
(23 ± 0.69 mm) and
Bacillus subtilis
(12.67 ± 0.38 mm). The in vitro antioxidant study revealed the free radical scavenging activity of VC-AgNPs by 2,2-diphenyl-1-picrylhydrazyl and Nitric oxide at the inhibitory concentration (IC
50
) of 23.11 ± 2.05 µg/mL and 36.52 ± 2.37 µg/mL respectively. The anthelmintic efficacy of VC-AgNPs against
Pheretima posthumus
mortality was found to be 87% at 5 µg/cm
2
. VC-AgNPs showed significant larvicidal activity against
Culex quinquefasciatus
with a lethal dose of 0.788 ppm and also VC-AgNPs significantly inhibited the production of acetylcholinesterase with the IC
50
value of 0.875 ppm. VC-AgNPs displayed remarkable cytotoxicity against the lung cancer cell line A549 in a dose dependent way with the IC
50
value of 125 µg/mL. We demonstrated that VC-AgNPs can be further exploited as a potential candidate for antibacterial, antioxidant, anthelmintic, larvicidal, anti-acetylcholinesterase and anticancer activity.
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E. coli
(23 ± 0.69 mm) and
Bacillus subtilis
(12.67 ± 0.38 mm). The in vitro antioxidant study revealed the free radical scavenging activity of VC-AgNPs by 2,2-diphenyl-1-picrylhydrazyl and Nitric oxide at the inhibitory concentration (IC
50
) of 23.11 ± 2.05 µg/mL and 36.52 ± 2.37 µg/mL respectively. The anthelmintic efficacy of VC-AgNPs against
Pheretima posthumus
mortality was found to be 87% at 5 µg/cm
2
. VC-AgNPs showed significant larvicidal activity against
Culex quinquefasciatus
with a lethal dose of 0.788 ppm and also VC-AgNPs significantly inhibited the production of acetylcholinesterase with the IC
50
value of 0.875 ppm. VC-AgNPs displayed remarkable cytotoxicity against the lung cancer cell line A549 in a dose dependent way with the IC
50
value of 125 µg/mL. We demonstrated that VC-AgNPs can be further exploited as a potential candidate for antibacterial, antioxidant, anthelmintic, larvicidal, anti-acetylcholinesterase and anticancer activity.
Graphic Abstract</description><subject>Anticancer properties</subject><subject>Antioxidants</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Biosynthesis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>E coli</subject><subject>Fourier transforms</subject><subject>Free radicals</subject><subject>Inorganic Chemistry</subject><subject>Nanoparticles</subject><subject>Nitric oxide</subject><subject>Organic Chemistry</subject><subject>Photon correlation spectroscopy</subject><subject>Polymer Sciences</subject><subject>Reducing agents</subject><subject>Scavenging</subject><subject>Silver</subject><subject>Spectrum analysis</subject><subject>Toxicity</subject><subject>Visible spectrum</subject><subject>Zeta potential</subject><issn>1574-1443</issn><issn>1574-1451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMFOwzAQRC0EEqXwA5wscQ6sY8dOjqWCglQBEi1Xy06d1lVqBzsg9e9xCYIbp53DzOzuQ-iSwDUBEDeRQAUsgxwyILykmThCI1IIlhFWkONfzegpOotxC0BLKMgI-VkwxuFb6-Pe9RsTbcS-wa-2_TQBPynnOxV6W7cm4mW0bo3fVNuqoCyebrwPyqkdVm6FFxtjA37xvXG9Ve2hcWdWtk5y0nVtEr31Lp6jk0a10Vz8zDFa3t8tpg_Z_Hn2OJ3Ms5oWvM8MVwpWuqS6ZhXjWhiq6rLQJh2uQeel4qQRtObpJV5VIqeclqzJWWE0FLmmY3Q19HbBv3-Y2Mut_wgurZTJBKLMCefJlQ-uOvgYg2lkF-xOhb0kIA9g5QBWJrDyG6wUKUSHUExmtzbhr_qf1Bf_63wY</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Sathiyaraj, Sivaji</creator><creator>Suriyakala, Gunasekaran</creator><creator>Gandhi, Arumugam Dhanesh</creator><creator>Saranya, Sivakumar</creator><creator>Santhoshkumar, Murali</creator><creator>Kavitha, Purushothaman</creator><creator>Babujanarthanam, Ranganathan</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20201101</creationdate><title>Green Biosynthesis of Silver Nanoparticles Using Vallarai Chooranam and Their Potential Biomedical Applications</title><author>Sathiyaraj, Sivaji ; Suriyakala, Gunasekaran ; Gandhi, Arumugam Dhanesh ; Saranya, Sivakumar ; Santhoshkumar, Murali ; Kavitha, Purushothaman ; Babujanarthanam, Ranganathan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-e6aa0db83bc4946b7e3ac85be003b0b28a61f73c61446997236384f245eb052b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anticancer properties</topic><topic>Antioxidants</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Biosynthesis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>E coli</topic><topic>Fourier transforms</topic><topic>Free radicals</topic><topic>Inorganic Chemistry</topic><topic>Nanoparticles</topic><topic>Nitric oxide</topic><topic>Organic Chemistry</topic><topic>Photon correlation spectroscopy</topic><topic>Polymer Sciences</topic><topic>Reducing agents</topic><topic>Scavenging</topic><topic>Silver</topic><topic>Spectrum analysis</topic><topic>Toxicity</topic><topic>Visible spectrum</topic><topic>Zeta potential</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sathiyaraj, Sivaji</creatorcontrib><creatorcontrib>Suriyakala, Gunasekaran</creatorcontrib><creatorcontrib>Gandhi, Arumugam Dhanesh</creatorcontrib><creatorcontrib>Saranya, Sivakumar</creatorcontrib><creatorcontrib>Santhoshkumar, Murali</creatorcontrib><creatorcontrib>Kavitha, Purushothaman</creatorcontrib><creatorcontrib>Babujanarthanam, Ranganathan</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of inorganic and organometallic polymers and materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sathiyaraj, Sivaji</au><au>Suriyakala, Gunasekaran</au><au>Gandhi, Arumugam Dhanesh</au><au>Saranya, Sivakumar</au><au>Santhoshkumar, Murali</au><au>Kavitha, Purushothaman</au><au>Babujanarthanam, Ranganathan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Green Biosynthesis of Silver Nanoparticles Using Vallarai Chooranam and Their Potential Biomedical Applications</atitle><jtitle>Journal of inorganic and organometallic polymers and materials</jtitle><stitle>J Inorg Organomet Polym</stitle><date>2020-11-01</date><risdate>2020</risdate><volume>30</volume><issue>11</issue><spage>4709</spage><epage>4719</epage><pages>4709-4719</pages><issn>1574-1443</issn><eissn>1574-1451</eissn><abstract>The synthesis of silver nanoparticles was done using vallarai chooranam as a bio reducing agent and ascertained by UV–Visible spectrum at 432 nm. Fourier transform infra-red spectrum revealed that the proteins and other ligands were liable for the capping of synthesized silver nanoparticles (VC-AgNPs). Crystalline nature, spherical shapes particles with the size between 40 to 50 nm and elemental composition were found using X-ray Diffraction, Transmission Electron Microscopy and Energy-dispersive X-ray spectroscopy. By using Dynamic Light Scattering analysis, the average size of silver nanoparticles was found to be 43.1 nm and the zeta potential value was − 47.5 mV implying the stability of VC-AgNPs. The antibacterial activity of VC-AgNPs showed the maximum and minimum zone of inhibition towards
E. coli
(23 ± 0.69 mm) and
Bacillus subtilis
(12.67 ± 0.38 mm). The in vitro antioxidant study revealed the free radical scavenging activity of VC-AgNPs by 2,2-diphenyl-1-picrylhydrazyl and Nitric oxide at the inhibitory concentration (IC
50
) of 23.11 ± 2.05 µg/mL and 36.52 ± 2.37 µg/mL respectively. The anthelmintic efficacy of VC-AgNPs against
Pheretima posthumus
mortality was found to be 87% at 5 µg/cm
2
. VC-AgNPs showed significant larvicidal activity against
Culex quinquefasciatus
with a lethal dose of 0.788 ppm and also VC-AgNPs significantly inhibited the production of acetylcholinesterase with the IC
50
value of 0.875 ppm. VC-AgNPs displayed remarkable cytotoxicity against the lung cancer cell line A549 in a dose dependent way with the IC
50
value of 125 µg/mL. We demonstrated that VC-AgNPs can be further exploited as a potential candidate for antibacterial, antioxidant, anthelmintic, larvicidal, anti-acetylcholinesterase and anticancer activity.
Graphic Abstract</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10904-020-01683-7</doi><tpages>11</tpages></addata></record> |
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| subjects | Anticancer properties Antioxidants Biocompatibility Biomedical materials Biosynthesis Chemistry Chemistry and Materials Science E coli Fourier transforms Free radicals Inorganic Chemistry Nanoparticles Nitric oxide Organic Chemistry Photon correlation spectroscopy Polymer Sciences Reducing agents Scavenging Silver Spectrum analysis Toxicity Visible spectrum Zeta potential |
| title | Green Biosynthesis of Silver Nanoparticles Using Vallarai Chooranam and Their Potential Biomedical Applications |
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