Clinical Trials with an Adaptive Choice of Hypotheses
In a clinical trial with an adaptive interim analysis it is possible to modify not only the design, but even the hypothesis(es) of interest, in a formally correct manner. Two examples of clinical trials are described where modifications of hypotheses are based on substantial scientific reasons. Gene...
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| Veröffentlicht in: | Drug information journal 2001-10, Vol.35 (4), p.1423-1429 |
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| container_title | Drug information journal |
| container_volume | 35 |
| creator | Hommel, Gerhard Kropf, Siegfried |
| description | In a clinical trial with an adaptive interim analysis it is possible to modify not only the design, but even the hypothesis(es) of interest, in a formally correct manner. Two examples of clinical trials are described where modifications of hypotheses are based on substantial scientific reasons. Generally, it is emphasized that the danger of manipulation caused by flexible designs must be controlled by very restrictive guidelines. |
| doi_str_mv | 10.1177/009286150103500438 |
| format | Article |
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Two examples of clinical trials are described where modifications of hypotheses are based on substantial scientific reasons. Generally, it is emphasized that the danger of manipulation caused by flexible designs must be controlled by very restrictive guidelines.</description><subject>Biological and medical sciences</subject><subject>Clinical trial. Drug monitoring</subject><subject>Clinical trials</subject><subject>Design modifications</subject><subject>General pharmacology</subject><subject>Hypotheses</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Drug monitoring</topic><topic>Clinical trials</topic><topic>Design modifications</topic><topic>General pharmacology</topic><topic>Hypotheses</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hommel, Gerhard</creatorcontrib><creatorcontrib>Kropf, Siegfried</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Drug information journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hommel, Gerhard</au><au>Kropf, Siegfried</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Trials with an Adaptive Choice of Hypotheses</atitle><jtitle>Drug information journal</jtitle><date>2001-10-01</date><risdate>2001</risdate><volume>35</volume><issue>4</issue><spage>1423</spage><epage>1429</epage><pages>1423-1429</pages><issn>2168-4790</issn><issn>0092-8615</issn><eissn>2168-4804</eissn><eissn>2164-9200</eissn><abstract>In a clinical trial with an adaptive interim analysis it is possible to modify not only the design, but even the hypothesis(es) of interest, in a formally correct manner. 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| fulltext | fulltext |
| identifier | ISSN: 2168-4790 |
| ispartof | Drug information journal, 2001-10, Vol.35 (4), p.1423-1429 |
| issn | 2168-4790 0092-8615 2168-4804 2164-9200 |
| language | eng |
| recordid | cdi_proquest_journals_2450780587 |
| source | SAGE Complete A-Z List; SpringerLink Journals - AutoHoldings |
| subjects | Biological and medical sciences Clinical trial. Drug monitoring Clinical trials Design modifications General pharmacology Hypotheses Medical sciences Pharmacology. Drug treatments |
| title | Clinical Trials with an Adaptive Choice of Hypotheses |
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