Neuroprotective and Antiapoptotic Effects of Allopregnanolone and Curcumin on Arsenic-Induced Toxicity in SH-SY5Y Dopaminergic Human Neuroblastoma Cells

Parkinson’s disease (PD) is a widespread neurological disorder mainly characterized by gradual death of dopaminergic neurons in the basal ganglia. In our study, we compared the effects of curcumin (Curc) as a herbal medicine and those of allopregnanolone (Allo) as a synthetic drug on arsenic(Ars-)-i...

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Veröffentlicht in:	Neurophysiology (New York) 2020-03, Vol.52 (2), p.124-133
Hauptverfasser:	Khodadadi, H., Jahromi, G. P., Zaeinalifard, G., Fasihi-Ramandi, M., Esmaeili, M., Shahriary, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antioxidants Apoptosis Arsenic Basal ganglia Biomedical and Life Sciences Biomedicine c-Fos protein Caspase-3 Cell survival Curcumin Dopamine receptors Ethylenediaminetetraacetic acid Fluorescence Herbal medicine Immunoblotting Intracellular Medicine, Botanic Medicine, Herbal Membrane potential Mitochondria Movement disorders Nervous system diseases Neuroblastoma Neuroblasts Neurodegenerative diseases Neuroprotection Neurosciences Neurotoxicity Parkinson's disease Pregnanolone Reactive oxygen species
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