The Mechanism of Suppression of Chronic Hepatitis C Infection by the Medicine Stimforte
The effect of the drug Stimforte on infection by the Hepatitis C virus (HCV) has been studied. Stimforte partially inhibits HCV infection at a dose of 100 μg/mouse and almost completely at a dose of 300 μg/mouse within 24 h after administration of the drug. The mice sera resulting after 24 h in the...
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| Veröffentlicht in: | Biology bulletin of the Russian Academy of Sciences 2020-09, Vol.47 (5), p.448-454 |
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| creator | Mishin, D. V. Isaeva, E. I. Grigorian, S. S. Balakina, A. A. Ilyichev, A. V. Deryabin, P. G. Maldov, D. G. |
| description | The effect of the drug Stimforte on infection by the Hepatitis C virus (HCV) has been studied. Stimforte partially inhibits HCV infection at a dose of 100 μg/mouse and almost completely at a dose of 300 μg/mouse within 24 h after administration of the drug. The mice sera resulting after 24 h in the presence of 100 and 300 µg/mouse of Stimforte effectively inhibit the production of HCV. Doses of 150, 200, and 250 µg/mouse are not effective. Stimulation of interferon-β (IFN-β) production is only observed at doses of 100 and 300 µg/mouse, which explains well the neutralizing capacity of the sera. The amount of IFN-γ also correlates well with the antiviral activity and neutralizing activity of mice sera. The drug practically does not stimulate production of IFN-λ. Thus, the neutralizing activity of sera and the antiviral activity are largely determined by the 1st and 2nd IFN groups. |
| doi_str_mv | 10.1134/S1062359020050076 |
| format | Article |
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The drug practically does not stimulate production of IFN-λ. 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Stimulation of interferon-β (IFN-β) production is only observed at doses of 100 and 300 µg/mouse, which explains well the neutralizing capacity of the sera. The amount of IFN-γ also correlates well with the antiviral activity and neutralizing activity of mice sera. The drug practically does not stimulate production of IFN-λ. Thus, the neutralizing activity of sera and the antiviral activity are largely determined by the 1st and 2nd IFN groups.</description><subject>Antiviral activity</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Chronic infection</subject><subject>Drug dosages</subject><subject>Ecology</subject><subject>Hepatitis</subject><subject>Hepatitis C</subject><subject>Infections</subject><subject>Interferon</subject><subject>Life Sciences</subject><subject>Zoology</subject><subject>β-Interferon</subject><subject>γ-Interferon</subject><issn>1062-3590</issn><issn>1608-3059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kE9Lw0AQxRdRsFY_gLcFz9HZv0mOEtQWKh5a8Ri2m1m7xSZxd3votzexggfxNDO833vDDCHXDG4ZE_JuyUBzoUrgAAog1ydkwjQUmQBVng79IGejfk4uYtwCgBSST8jbaoP0Ge3GtD7uaOfoct_3AWP0XTuO1SZ0rbd0hr1JPvlIKzpvHdo0AusDTd8Bjbe-RbpMfue6kPCSnDnzEfHqp07J6-PDqppli5eneXW_yCzXRcpKpdAZgyhybvJ100jmciFzobDgWlshLEjjQKJw2hlX6EKVrBlOLkVRahRTcnPM7UP3uceY6m23D-2wsuZSgRBMajlQ7EjZ0MUY0NV98DsTDjWDevxf_ed_g4cfPXFg23cMv8n_m74AYRBwow</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Mishin, D. 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Stimulation of interferon-β (IFN-β) production is only observed at doses of 100 and 300 µg/mouse, which explains well the neutralizing capacity of the sera. The amount of IFN-γ also correlates well with the antiviral activity and neutralizing activity of mice sera. The drug practically does not stimulate production of IFN-λ. Thus, the neutralizing activity of sera and the antiviral activity are largely determined by the 1st and 2nd IFN groups.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1062359020050076</doi><tpages>7</tpages></addata></record> |
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| subjects | Antiviral activity Biochemistry Biomedical and Life Sciences Cell Biology Chronic infection Drug dosages Ecology Hepatitis Hepatitis C Infections Interferon Life Sciences Zoology β-Interferon γ-Interferon |
| title | The Mechanism of Suppression of Chronic Hepatitis C Infection by the Medicine Stimforte |
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