Long non-coding RNA ESCCAL-1 promotes esophageal squamous cell carcinoma by down regulating the negative regulator of APOBEC3G

The expression of lncRNA ESCCAL-1 is upregulated in esophageal squamous cell carcinoma (ESCC). However, the molecular pathways regulated by ESCCAL-1 in esophageal cancer remain obscure. We found that high expression of the lncRNA ESCCAL-1 in human ESCC tumors correlated with worse clinicopathologic...

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Veröffentlicht in:	Cancer letters 2020-11, Vol.493, p.217-227
Hauptverfasser:	Liu, Jia, Mayekar, Manasi K., Wu, Wei, Yan, Ming, Guan, Hongya, Wang, Jinwu, Zaman, Aubhishek, Cui, Yuanbo, Bivona, Trever G., Choudhry, Hani, Xing, Qinghe, Cao, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals APOBEC-3G Deaminase - genetics APOBEC-3G Deaminase - metabolism Apolipoproteins Apoptosis Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer therapies Cell growth Cell Line, Tumor Cell Movement Cell Proliferation Down-Regulation Enzymes Esophageal cancer Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal squamous cell carcinoma Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - metabolism Esophageal Squamous Cell Carcinoma - pathology Esophagus Female Gene expression Gene Expression Regulation, Neoplastic Genomes Humans Kinases LncRNA Male Malignancy Medical prognosis Metastasis Mice MicroRNAs MicroRNAs - genetics miR-590-3p Neoplasm Transplantation Non-coding RNA Phenotypes Phosphatase PI3K-Akt pathway Plasmids Polypeptides Prognosis Proteins RNA, Long Noncoding - genetics Squamous cell carcinoma Surgery Tumors
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