Maternal haemoglobin in pregnancy and offspring childhood weight and height trajectories: analysis of a prospective birth cohort study
Background : Both anaemia and high haemoglobin in pregnancy are associated with adverse pregnancy outcomes including foetal growth restriction. The objective of this study was to investigate the associations between maternal haemoglobin in pregnancy and trajectories of length/height and weight from...
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| Veröffentlicht in: | Wellcome open research 2020-10, Vol.5, p.236 |
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| creator | Pyne, Yvette V Howe, Laura D Fraser, Abigail |
| description | Background
: Both anaemia and high haemoglobin in pregnancy are associated with adverse pregnancy outcomes including foetal growth restriction. The objective of this study was to investigate the associations between maternal haemoglobin in pregnancy and trajectories of length/height and weight from birth through childhood.
Methods
: Data from 7,597 singleton pregnancies in the Avon Longitudinal Study of Parents and Children (ALSPAC), an ongoing, prospective, UK population-based pregnancy cohort study were used. We examined associations between maternal haemoglobin (overall pregnancy and trimester specific) and offspring length and weight at birth, as well as trajectories of height and weight gain from birth to age 10 years derived from multilevel models.
Results
: Mean pregnancy haemoglobin was 11.61 g/dL (SD 1.12). For each 1g/dL higher mean overall pregnancy haemoglobin, offspring were on average -0.30 cm shorter (95%CI: -0.35, -0.24, p |
| doi_str_mv | 10.12688/wellcomeopenres.16283.1 |
| format | Article |
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: Both anaemia and high haemoglobin in pregnancy are associated with adverse pregnancy outcomes including foetal growth restriction. The objective of this study was to investigate the associations between maternal haemoglobin in pregnancy and trajectories of length/height and weight from birth through childhood.
Methods
: Data from 7,597 singleton pregnancies in the Avon Longitudinal Study of Parents and Children (ALSPAC), an ongoing, prospective, UK population-based pregnancy cohort study were used. We examined associations between maternal haemoglobin (overall pregnancy and trimester specific) and offspring length and weight at birth, as well as trajectories of height and weight gain from birth to age 10 years derived from multilevel models.
Results
: Mean pregnancy haemoglobin was 11.61 g/dL (SD 1.12). For each 1g/dL higher mean overall pregnancy haemoglobin, offspring were on average -0.30 cm shorter (95%CI: -0.35, -0.24, p <0.001), and -97.7 g lighter (95%CI: -110.42, -84.93, p <0.001) at birth when adjusting for potential confounders. Trimester specific inverse associations with birth length and weight were strongest for third trimester haemoglobin. There was evidence of a positive association between maternal haemoglobin levels and offspring height gain up to the age of one year and no strong evidence of associations between pregnancy haemoglobin and childhood weight gain.
Conclusions
: In high income countries, higher maternal haemoglobin in pregnancy may be a concern, as well as anaemia. Further studies are needed to define ‘high’ haemoglobin in pregnancy and whether monitoring of women with high pregnancy haemoglobin is warranted.</description><identifier>ISSN: 2398-502X</identifier><identifier>EISSN: 2398-502X</identifier><identifier>DOI: 10.12688/wellcomeopenres.16283.1</identifier><language>eng</language><publisher>London: Wellcome Trust Limited</publisher><subject>Age ; Anemia ; Birth weight ; Body mass index ; Childhood ; Cohort analysis ; Data dictionaries ; Ethics ; Ethnicity ; Gender ; Health visiting ; Hemoglobin ; Households ; Iron ; Medical records ; Mothers ; Peer review ; Population ; Pregnancy ; Questionnaires ; Social classes ; Ultrasonic imaging ; Womens health</subject><ispartof>Wellcome open research, 2020-10, Vol.5, p.236</ispartof><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1271-4b53521eb0018950720f45e91057942f3ee5e50d71496355f325aca31b0650603</cites><orcidid>0000-0003-3357-2796 ; 0000-0002-7741-9470 ; 0000-0001-5920-484X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Pyne, Yvette V</creatorcontrib><creatorcontrib>Howe, Laura D</creatorcontrib><creatorcontrib>Fraser, Abigail</creatorcontrib><title>Maternal haemoglobin in pregnancy and offspring childhood weight and height trajectories: analysis of a prospective birth cohort study</title><title>Wellcome open research</title><description>Background
: Both anaemia and high haemoglobin in pregnancy are associated with adverse pregnancy outcomes including foetal growth restriction. The objective of this study was to investigate the associations between maternal haemoglobin in pregnancy and trajectories of length/height and weight from birth through childhood.
Methods
: Data from 7,597 singleton pregnancies in the Avon Longitudinal Study of Parents and Children (ALSPAC), an ongoing, prospective, UK population-based pregnancy cohort study were used. We examined associations between maternal haemoglobin (overall pregnancy and trimester specific) and offspring length and weight at birth, as well as trajectories of height and weight gain from birth to age 10 years derived from multilevel models.
Results
: Mean pregnancy haemoglobin was 11.61 g/dL (SD 1.12). For each 1g/dL higher mean overall pregnancy haemoglobin, offspring were on average -0.30 cm shorter (95%CI: -0.35, -0.24, p <0.001), and -97.7 g lighter (95%CI: -110.42, -84.93, p <0.001) at birth when adjusting for potential confounders. Trimester specific inverse associations with birth length and weight were strongest for third trimester haemoglobin. There was evidence of a positive association between maternal haemoglobin levels and offspring height gain up to the age of one year and no strong evidence of associations between pregnancy haemoglobin and childhood weight gain.
Conclusions
: In high income countries, higher maternal haemoglobin in pregnancy may be a concern, as well as anaemia. Further studies are needed to define ‘high’ haemoglobin in pregnancy and whether monitoring of women with high pregnancy haemoglobin is warranted.</description><subject>Age</subject><subject>Anemia</subject><subject>Birth weight</subject><subject>Body mass index</subject><subject>Childhood</subject><subject>Cohort analysis</subject><subject>Data dictionaries</subject><subject>Ethics</subject><subject>Ethnicity</subject><subject>Gender</subject><subject>Health visiting</subject><subject>Hemoglobin</subject><subject>Households</subject><subject>Iron</subject><subject>Medical records</subject><subject>Mothers</subject><subject>Peer review</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Questionnaires</subject><subject>Social classes</subject><subject>Ultrasonic imaging</subject><subject>Womens health</subject><issn>2398-502X</issn><issn>2398-502X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdUMtqwzAQFKWFhjT_IOjZqR6WH72V0Bek9NJCb0KW17aCY7mS0uAf6HdXSXoohYUdmNllZhDClCwpy4riZg99r-0W7AiDA7-kGSv4kp6hGeNlkQjCPs7_4Eu08H5DCKFFFBZkhr5fVAA3qB53Cra27W1lBhxndNAOatATVkONbdP40Zmhxbozfd1ZW-M9mLYLR7o7weDUBnSwzoC_jYTqJ298PMYq_rN-jKT5AlwZFzqsbWddwD7s6ukKXTSq97D43XP0_nD_tnpK1q-Pz6u7daIpy2mSVoILRqE6JCgFyRlpUgElJSIvU9ZwAAGC1DlNy4wL0XAmlFacViQTJCN8jq5Pf6Odzx34IDd2d4jvJUvTMuc0ZSyqipNKR9PeQSNj9q1yk6REHouX_4qXx-Il5T88QH2I</recordid><startdate>20201009</startdate><enddate>20201009</enddate><creator>Pyne, Yvette V</creator><creator>Howe, Laura D</creator><creator>Fraser, Abigail</creator><general>Wellcome Trust Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-3357-2796</orcidid><orcidid>https://orcid.org/0000-0002-7741-9470</orcidid><orcidid>https://orcid.org/0000-0001-5920-484X</orcidid></search><sort><creationdate>20201009</creationdate><title>Maternal haemoglobin in pregnancy and offspring childhood weight and height trajectories: analysis of a prospective birth cohort study</title><author>Pyne, Yvette V ; Howe, Laura D ; Fraser, Abigail</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1271-4b53521eb0018950720f45e91057942f3ee5e50d71496355f325aca31b0650603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Anemia</topic><topic>Birth weight</topic><topic>Body mass index</topic><topic>Childhood</topic><topic>Cohort analysis</topic><topic>Data dictionaries</topic><topic>Ethics</topic><topic>Ethnicity</topic><topic>Gender</topic><topic>Health visiting</topic><topic>Hemoglobin</topic><topic>Households</topic><topic>Iron</topic><topic>Medical records</topic><topic>Mothers</topic><topic>Peer review</topic><topic>Population</topic><topic>Pregnancy</topic><topic>Questionnaires</topic><topic>Social classes</topic><topic>Ultrasonic imaging</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pyne, Yvette V</creatorcontrib><creatorcontrib>Howe, Laura D</creatorcontrib><creatorcontrib>Fraser, Abigail</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Wellcome open research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pyne, Yvette V</au><au>Howe, Laura D</au><au>Fraser, Abigail</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal haemoglobin in pregnancy and offspring childhood weight and height trajectories: analysis of a prospective birth cohort study</atitle><jtitle>Wellcome open research</jtitle><date>2020-10-09</date><risdate>2020</risdate><volume>5</volume><spage>236</spage><pages>236-</pages><issn>2398-502X</issn><eissn>2398-502X</eissn><abstract>Background
: Both anaemia and high haemoglobin in pregnancy are associated with adverse pregnancy outcomes including foetal growth restriction. The objective of this study was to investigate the associations between maternal haemoglobin in pregnancy and trajectories of length/height and weight from birth through childhood.
Methods
: Data from 7,597 singleton pregnancies in the Avon Longitudinal Study of Parents and Children (ALSPAC), an ongoing, prospective, UK population-based pregnancy cohort study were used. We examined associations between maternal haemoglobin (overall pregnancy and trimester specific) and offspring length and weight at birth, as well as trajectories of height and weight gain from birth to age 10 years derived from multilevel models.
Results
: Mean pregnancy haemoglobin was 11.61 g/dL (SD 1.12). For each 1g/dL higher mean overall pregnancy haemoglobin, offspring were on average -0.30 cm shorter (95%CI: -0.35, -0.24, p <0.001), and -97.7 g lighter (95%CI: -110.42, -84.93, p <0.001) at birth when adjusting for potential confounders. Trimester specific inverse associations with birth length and weight were strongest for third trimester haemoglobin. There was evidence of a positive association between maternal haemoglobin levels and offspring height gain up to the age of one year and no strong evidence of associations between pregnancy haemoglobin and childhood weight gain.
Conclusions
: In high income countries, higher maternal haemoglobin in pregnancy may be a concern, as well as anaemia. Further studies are needed to define ‘high’ haemoglobin in pregnancy and whether monitoring of women with high pregnancy haemoglobin is warranted.</abstract><cop>London</cop><pub>Wellcome Trust Limited</pub><doi>10.12688/wellcomeopenres.16283.1</doi><orcidid>https://orcid.org/0000-0003-3357-2796</orcidid><orcidid>https://orcid.org/0000-0002-7741-9470</orcidid><orcidid>https://orcid.org/0000-0001-5920-484X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Age Anemia Birth weight Body mass index Childhood Cohort analysis Data dictionaries Ethics Ethnicity Gender Health visiting Hemoglobin Households Iron Medical records Mothers Peer review Population Pregnancy Questionnaires Social classes Ultrasonic imaging Womens health |
| title | Maternal haemoglobin in pregnancy and offspring childhood weight and height trajectories: analysis of a prospective birth cohort study |
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