Decreased lymphatic HIF-2a accentuates lymphatic remodeling in lymphedema

Pathologic lymphatic remodeling in lymphedema evolves during periods of tissue inflammation and hypoxia through poorly defined processes. In human and mouse lymphedema, there is a significant increase of hypoxia inducible factor 1 a (HIF-1a), but a reduction of HIF-2a protein expression in lymphatic...

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Veröffentlicht in:	The Journal of clinical investigation 2020-10, Vol.130 (10), p.5562-5575
Hauptverfasser:	Jiang, Xinguo, Tian, Wen, Granucci, Eric J, Tu, Allen B, Kim, Dongeon, Dahms, Petra, Pasupneti, Shravani, Peng, Gongyong, Kim, Yesl, Lim, Amber H, Espinoza, F Hernan, Cribb, Matthew, Dixon, J Brandon, Rockson, Stanley G, Semenza, Gregg L, Nicolls, Mark R
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietin Biomedical research Disease Edema Endothelial cells Fetuses Gene therapy Genes HIF-2a protein Homeostasis Hypoxia Hypoxia-inducible factor 1a Inflammation Ligands Lymphedema Pathogenesis Pathology Pathophysiology Surgery Transcription factors
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