Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy
The causes of nonischemic dilated cardiomyopathy are classified as genetic or nongenetic, but environmental factors such as metal pollutants may interact with genetic susceptibility. The presence of metal particles has been detected in the myocardium, including in those patients with dilated cardiom...
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| Veröffentlicht in: | Cardiovascular toxicology 2020-12, Vol.20 (6), p.571-580 |
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| creator | Manousek, Jan Felsoci, Marian Miklik, Roman Parenica, Jiri Krejci, Jan Bjørklund, Geir Klanova, Jana Mlejnek, Dalibor Miklikova, Marie Lokaj, Petr Chirumbolo, Salvatore Spinar, Jindrich |
| description | The causes of nonischemic dilated cardiomyopathy are classified as genetic or nongenetic, but environmental factors such as metal pollutants may interact with genetic susceptibility. The presence of metal particles has been detected in the myocardium, including in those patients with dilated cardiomyopathy. It is also known that hypersensitivity reactions can induce inflammation in tissue. The present study aimed to verify if metal-induced delayed-type hypersensitivity is present in patients with nonischemic dilated cardiomyopathy. The patient group consisted of 30 patients with newly diagnosed dilated cardiomyopathy; the control group comprised 41 healthy subjects. All patients and control subjects provided blood samples for lymphocyte transformation testing (MELISA®) to assess possible hypersensitivity to seven common metals. Specific exposure to metals was based on interview data. Results showed that exposure to cadmium and lead (
p
= 0.0002), aluminum (
p
= 0.0006), nickel (
p
= 0.0012), and chromium (
p
= 0.0065) was more often reported by patients than controls. The patients also had significantly more frequent hypersensitivity reactions to mercury (26.7% vs. 7.3%,
p
= 0.014624), nickel (40% vs. 12.2%,
p
= 0.02341), and silver (20% vs. 4.8%,
p
= 0.025468) than the control group. Patients with dilated cardiomyopathy had greater exposure to certain metals compared with healthy controls. Hypersensitivity to metals was more frequent in patients with dilated cardiomyopathy, suggesting a possible association that warrants further investigation. |
| doi_str_mv | 10.1007/s12012-020-09582-6 |
| format | Article |
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p
= 0.0002), aluminum (
p
= 0.0006), nickel (
p
= 0.0012), and chromium (
p
= 0.0065) was more often reported by patients than controls. The patients also had significantly more frequent hypersensitivity reactions to mercury (26.7% vs. 7.3%,
p
= 0.014624), nickel (40% vs. 12.2%,
p
= 0.02341), and silver (20% vs. 4.8%,
p
= 0.025468) than the control group. Patients with dilated cardiomyopathy had greater exposure to certain metals compared with healthy controls. Hypersensitivity to metals was more frequent in patients with dilated cardiomyopathy, suggesting a possible association that warrants further investigation.</description><identifier>ISSN: 1530-7905</identifier><identifier>EISSN: 1559-0259</identifier><identifier>DOI: 10.1007/s12012-020-09582-6</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aluminum ; Biomedical and Life Sciences ; Biomedicine ; Cadmium ; Cardiology ; Cardiomyopathy ; Chromium ; Dilated cardiomyopathy ; Environmental factors ; Exposure ; Genetic transformation ; Heavy metals ; Heredity ; Hypersensitivity ; Hypersensitivity (delayed) ; Lymphocyte transformation ; Lymphocytes ; Mercury ; Mercury (metal) ; Metal particles ; Metals ; Myocardium ; Nickel ; Pharmacology/Toxicology ; Pollutants ; Silver</subject><ispartof>Cardiovascular toxicology, 2020-12, Vol.20 (6), p.571-580</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-b171ac38fa339dad30e230080a2fbdd89888d6511bc854926fb4e242302412fa3</citedby><cites>FETCH-LOGICAL-c352t-b171ac38fa339dad30e230080a2fbdd89888d6511bc854926fb4e242302412fa3</cites><orcidid>0000-0003-2632-3935</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12012-020-09582-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12012-020-09582-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids></links><search><creatorcontrib>Manousek, Jan</creatorcontrib><creatorcontrib>Felsoci, Marian</creatorcontrib><creatorcontrib>Miklik, Roman</creatorcontrib><creatorcontrib>Parenica, Jiri</creatorcontrib><creatorcontrib>Krejci, Jan</creatorcontrib><creatorcontrib>Bjørklund, Geir</creatorcontrib><creatorcontrib>Klanova, Jana</creatorcontrib><creatorcontrib>Mlejnek, Dalibor</creatorcontrib><creatorcontrib>Miklikova, Marie</creatorcontrib><creatorcontrib>Lokaj, Petr</creatorcontrib><creatorcontrib>Chirumbolo, Salvatore</creatorcontrib><creatorcontrib>Spinar, Jindrich</creatorcontrib><title>Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy</title><title>Cardiovascular toxicology</title><addtitle>Cardiovasc Toxicol</addtitle><description>The causes of nonischemic dilated cardiomyopathy are classified as genetic or nongenetic, but environmental factors such as metal pollutants may interact with genetic susceptibility. The presence of metal particles has been detected in the myocardium, including in those patients with dilated cardiomyopathy. It is also known that hypersensitivity reactions can induce inflammation in tissue. The present study aimed to verify if metal-induced delayed-type hypersensitivity is present in patients with nonischemic dilated cardiomyopathy. The patient group consisted of 30 patients with newly diagnosed dilated cardiomyopathy; the control group comprised 41 healthy subjects. All patients and control subjects provided blood samples for lymphocyte transformation testing (MELISA®) to assess possible hypersensitivity to seven common metals. Specific exposure to metals was based on interview data. Results showed that exposure to cadmium and lead (
p
= 0.0002), aluminum (
p
= 0.0006), nickel (
p
= 0.0012), and chromium (
p
= 0.0065) was more often reported by patients than controls. The patients also had significantly more frequent hypersensitivity reactions to mercury (26.7% vs. 7.3%,
p
= 0.014624), nickel (40% vs. 12.2%,
p
= 0.02341), and silver (20% vs. 4.8%,
p
= 0.025468) than the control group. Patients with dilated cardiomyopathy had greater exposure to certain metals compared with healthy controls. Hypersensitivity to metals was more frequent in patients with dilated cardiomyopathy, suggesting a possible association that warrants further investigation.</description><subject>Aluminum</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cadmium</subject><subject>Cardiology</subject><subject>Cardiomyopathy</subject><subject>Chromium</subject><subject>Dilated cardiomyopathy</subject><subject>Environmental factors</subject><subject>Exposure</subject><subject>Genetic transformation</subject><subject>Heavy metals</subject><subject>Heredity</subject><subject>Hypersensitivity</subject><subject>Hypersensitivity (delayed)</subject><subject>Lymphocyte transformation</subject><subject>Lymphocytes</subject><subject>Mercury</subject><subject>Mercury (metal)</subject><subject>Metal particles</subject><subject>Metals</subject><subject>Myocardium</subject><subject>Nickel</subject><subject>Pharmacology/Toxicology</subject><subject>Pollutants</subject><subject>Silver</subject><issn>1530-7905</issn><issn>1559-0259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kM1KAzEURoMoWKsv4CrgOprfaWYprVqhVhe6DplJpk2dTmoSLfP2po7gzs3NJZzzXfgAuCT4mmA8uYmEYkIRphjhUkiKiiMwIkKU-UuUx4edYTQpsTgFZzFuMKaUFmIE3me21b01KPU7C-d5hGi76JL7cqmHycMnm3Qboevg0u7bHs6cXnU-WgNfdHK2SxHuXVrDpe9crNd26-rMtDplYqqDcX7b-51O6_4cnDQ5yl78vmPwdn_3Op2jxfPD4_R2gWomaEIVmRBdM9loxkqjDcOWMowl1rSpjJGllNIUgpCqloKXtGgqbinPDOWEZmsMrobcXfAfnzYmtfGfocsnFeW85FkqeKboQNXBxxhso3bBbXXoFcHqUKoaSlW5VPVTqiqyxAYpZrhb2fAX_Y_1DUAzexQ</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Manousek, Jan</creator><creator>Felsoci, Marian</creator><creator>Miklik, Roman</creator><creator>Parenica, Jiri</creator><creator>Krejci, Jan</creator><creator>Bjørklund, Geir</creator><creator>Klanova, Jana</creator><creator>Mlejnek, Dalibor</creator><creator>Miklikova, Marie</creator><creator>Lokaj, Petr</creator><creator>Chirumbolo, Salvatore</creator><creator>Spinar, Jindrich</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-2632-3935</orcidid></search><sort><creationdate>20201201</creationdate><title>Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy</title><author>Manousek, Jan ; Felsoci, Marian ; Miklik, Roman ; Parenica, Jiri ; Krejci, Jan ; Bjørklund, Geir ; Klanova, Jana ; Mlejnek, Dalibor ; Miklikova, Marie ; Lokaj, Petr ; Chirumbolo, Salvatore ; Spinar, Jindrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-b171ac38fa339dad30e230080a2fbdd89888d6511bc854926fb4e242302412fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aluminum</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cadmium</topic><topic>Cardiology</topic><topic>Cardiomyopathy</topic><topic>Chromium</topic><topic>Dilated cardiomyopathy</topic><topic>Environmental factors</topic><topic>Exposure</topic><topic>Genetic transformation</topic><topic>Heavy metals</topic><topic>Heredity</topic><topic>Hypersensitivity</topic><topic>Hypersensitivity (delayed)</topic><topic>Lymphocyte transformation</topic><topic>Lymphocytes</topic><topic>Mercury</topic><topic>Mercury (metal)</topic><topic>Metal particles</topic><topic>Metals</topic><topic>Myocardium</topic><topic>Nickel</topic><topic>Pharmacology/Toxicology</topic><topic>Pollutants</topic><topic>Silver</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manousek, Jan</creatorcontrib><creatorcontrib>Felsoci, Marian</creatorcontrib><creatorcontrib>Miklik, Roman</creatorcontrib><creatorcontrib>Parenica, Jiri</creatorcontrib><creatorcontrib>Krejci, Jan</creatorcontrib><creatorcontrib>Bjørklund, Geir</creatorcontrib><creatorcontrib>Klanova, Jana</creatorcontrib><creatorcontrib>Mlejnek, Dalibor</creatorcontrib><creatorcontrib>Miklikova, Marie</creatorcontrib><creatorcontrib>Lokaj, Petr</creatorcontrib><creatorcontrib>Chirumbolo, Salvatore</creatorcontrib><creatorcontrib>Spinar, Jindrich</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Cardiovascular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manousek, Jan</au><au>Felsoci, Marian</au><au>Miklik, Roman</au><au>Parenica, Jiri</au><au>Krejci, Jan</au><au>Bjørklund, Geir</au><au>Klanova, Jana</au><au>Mlejnek, Dalibor</au><au>Miklikova, Marie</au><au>Lokaj, Petr</au><au>Chirumbolo, Salvatore</au><au>Spinar, Jindrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy</atitle><jtitle>Cardiovascular toxicology</jtitle><stitle>Cardiovasc Toxicol</stitle><date>2020-12-01</date><risdate>2020</risdate><volume>20</volume><issue>6</issue><spage>571</spage><epage>580</epage><pages>571-580</pages><issn>1530-7905</issn><eissn>1559-0259</eissn><abstract>The causes of nonischemic dilated cardiomyopathy are classified as genetic or nongenetic, but environmental factors such as metal pollutants may interact with genetic susceptibility. The presence of metal particles has been detected in the myocardium, including in those patients with dilated cardiomyopathy. It is also known that hypersensitivity reactions can induce inflammation in tissue. The present study aimed to verify if metal-induced delayed-type hypersensitivity is present in patients with nonischemic dilated cardiomyopathy. The patient group consisted of 30 patients with newly diagnosed dilated cardiomyopathy; the control group comprised 41 healthy subjects. All patients and control subjects provided blood samples for lymphocyte transformation testing (MELISA®) to assess possible hypersensitivity to seven common metals. Specific exposure to metals was based on interview data. Results showed that exposure to cadmium and lead (
p
= 0.0002), aluminum (
p
= 0.0006), nickel (
p
= 0.0012), and chromium (
p
= 0.0065) was more often reported by patients than controls. The patients also had significantly more frequent hypersensitivity reactions to mercury (26.7% vs. 7.3%,
p
= 0.014624), nickel (40% vs. 12.2%,
p
= 0.02341), and silver (20% vs. 4.8%,
p
= 0.025468) than the control group. Patients with dilated cardiomyopathy had greater exposure to certain metals compared with healthy controls. Hypersensitivity to metals was more frequent in patients with dilated cardiomyopathy, suggesting a possible association that warrants further investigation.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s12012-020-09582-6</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2632-3935</orcidid></addata></record> |
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| subjects | Aluminum Biomedical and Life Sciences Biomedicine Cadmium Cardiology Cardiomyopathy Chromium Dilated cardiomyopathy Environmental factors Exposure Genetic transformation Heavy metals Heredity Hypersensitivity Hypersensitivity (delayed) Lymphocyte transformation Lymphocytes Mercury Mercury (metal) Metal particles Metals Myocardium Nickel Pharmacology/Toxicology Pollutants Silver |
| title | Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy |
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