Association of salivary inflammatory biomarkers with primary Sjögren's syndrome

Background Primary Sjogren's syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associated with T helper‐2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the sa...

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Veröffentlicht in:Journal of oral pathology & medicine 2020-10, Vol.49 (9), p.940-947
Hauptverfasser: Moreno‐Quispe, Luz A., Serrano, Julia, Virto, Leire, Sanz, Mariano, Ramírez, Lucía, Fernández‐Castro, Mónica, Hernández, Gonzalo, López‐Pintor, Rosa María
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container_end_page 947
container_issue 9
container_start_page 940
container_title Journal of oral pathology & medicine
container_volume 49
creator Moreno‐Quispe, Luz A.
Serrano, Julia
Virto, Leire
Sanz, Mariano
Ramírez, Lucía
Fernández‐Castro, Mónica
Hernández, Gonzalo
López‐Pintor, Rosa María
description Background Primary Sjogren's syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associated with T helper‐2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of interleukin (IL)‐6, IL‐5, and IL‐4 in patients with pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with salivary flow, patient‐reported outcomes (PROMs) for xerostomia and oral health quality of life (Oral Health Impact Profile‐14 [OHIP‐14]), pSS classification criteria and presence of extraglandular manifestations. Methods A case‐control study was conducted in 36 patients with pSS and 35 HCs. Cytokine levels were measured using high‐sensitivity multiplex map human immunoassays. Unstimulated and stimulated whole saliva were collected and patients filled out questionnaires. The Mann‐Whitney U test, chi‐squared test, and Spearman correlation test were used. Results Interleukin‐6 was significantly higher in pSS patients than in HCs (P = .0001). IL‐6 was significantly higher in pSS patients with a positive salivary gland biopsy (P = .04), whole stimulated saliva hyposalivation (P = .02), and presence of musculoskeletal disorders (P = .03). There was a non‐significant positive correlation between IL‐6 levels and PROMs for xerostomia (r = .31; P = .06) and OHIP‐14 (r = .07; P = .68) in pSS patients. Levels of IL‐4 and IL‐5 were not detected in both pSS and HCs patients. Conclusions Salivary IL‐6 levels are significantly associated with pSS patients, and therefore, it is hypothesized that this biomarker may be useful in the diagnosis and follow‐up of this disease.
doi_str_mv 10.1111/jop.13070
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The adaptive immune response associated with T helper‐2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of interleukin (IL)‐6, IL‐5, and IL‐4 in patients with pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with salivary flow, patient‐reported outcomes (PROMs) for xerostomia and oral health quality of life (Oral Health Impact Profile‐14 [OHIP‐14]), pSS classification criteria and presence of extraglandular manifestations. Methods A case‐control study was conducted in 36 patients with pSS and 35 HCs. Cytokine levels were measured using high‐sensitivity multiplex map human immunoassays. Unstimulated and stimulated whole saliva were collected and patients filled out questionnaires. The Mann‐Whitney U test, chi‐squared test, and Spearman correlation test were used. Results Interleukin‐6 was significantly higher in pSS patients than in HCs (P = .0001). IL‐6 was significantly higher in pSS patients with a positive salivary gland biopsy (P = .04), whole stimulated saliva hyposalivation (P = .02), and presence of musculoskeletal disorders (P = .03). There was a non‐significant positive correlation between IL‐6 levels and PROMs for xerostomia (r = .31; P = .06) and OHIP‐14 (r = .07; P = .68) in pSS patients. Levels of IL‐4 and IL‐5 were not detected in both pSS and HCs patients. Conclusions Salivary IL‐6 levels are significantly associated with pSS patients, and therefore, it is hypothesized that this biomarker may be useful in the diagnosis and follow‐up of this disease.</description><identifier>ISSN: 0904-2512</identifier><identifier>EISSN: 1600-0714</identifier><identifier>DOI: 10.1111/jop.13070</identifier><identifier>PMID: 32538490</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adaptive immunity ; Autoimmune diseases ; Biomarkers ; Biopsy ; Case-Control Studies ; Cytokines ; Humans ; Immune response ; Inflammation ; Lacrimal gland and Nasolacrimal duct ; Lymphocytes ; Lymphocytes T ; Musculoskeletal diseases ; Oral Health Impact Profile‐14 ; Oral hygiene ; primary Sjögren's syndrome ; Quality of Life ; Saliva ; Salivary biomarkers ; Salivary gland ; salivary interleukins ; Sjogren's syndrome ; Sjogren's Syndrome - diagnosis ; Visual Analog Scale for xerostomia ; Xerostomia</subject><ispartof>Journal of oral pathology &amp; medicine, 2020-10, Vol.49 (9), p.940-947</ispartof><rights>2020 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd</rights><rights>2020 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd.</rights><rights>Copyright © 2020 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3200-b5704f6394bc15a99e63f2dde10352e3761d695042bfbf2507db8203c4f7a3ee3</citedby><cites>FETCH-LOGICAL-c3200-b5704f6394bc15a99e63f2dde10352e3761d695042bfbf2507db8203c4f7a3ee3</cites><orcidid>0000-0002-5727-0920</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjop.13070$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjop.13070$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32538490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreno‐Quispe, Luz A.</creatorcontrib><creatorcontrib>Serrano, Julia</creatorcontrib><creatorcontrib>Virto, Leire</creatorcontrib><creatorcontrib>Sanz, Mariano</creatorcontrib><creatorcontrib>Ramírez, Lucía</creatorcontrib><creatorcontrib>Fernández‐Castro, Mónica</creatorcontrib><creatorcontrib>Hernández, Gonzalo</creatorcontrib><creatorcontrib>López‐Pintor, Rosa María</creatorcontrib><title>Association of salivary inflammatory biomarkers with primary Sjögren's syndrome</title><title>Journal of oral pathology &amp; medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Background Primary Sjogren's syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associated with T helper‐2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of interleukin (IL)‐6, IL‐5, and IL‐4 in patients with pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with salivary flow, patient‐reported outcomes (PROMs) for xerostomia and oral health quality of life (Oral Health Impact Profile‐14 [OHIP‐14]), pSS classification criteria and presence of extraglandular manifestations. Methods A case‐control study was conducted in 36 patients with pSS and 35 HCs. Cytokine levels were measured using high‐sensitivity multiplex map human immunoassays. Unstimulated and stimulated whole saliva were collected and patients filled out questionnaires. The Mann‐Whitney U test, chi‐squared test, and Spearman correlation test were used. Results Interleukin‐6 was significantly higher in pSS patients than in HCs (P = .0001). IL‐6 was significantly higher in pSS patients with a positive salivary gland biopsy (P = .04), whole stimulated saliva hyposalivation (P = .02), and presence of musculoskeletal disorders (P = .03). There was a non‐significant positive correlation between IL‐6 levels and PROMs for xerostomia (r = .31; P = .06) and OHIP‐14 (r = .07; P = .68) in pSS patients. Levels of IL‐4 and IL‐5 were not detected in both pSS and HCs patients. Conclusions Salivary IL‐6 levels are significantly associated with pSS patients, and therefore, it is hypothesized that this biomarker may be useful in the diagnosis and follow‐up of this disease.</description><subject>Adaptive immunity</subject><subject>Autoimmune diseases</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Case-Control Studies</subject><subject>Cytokines</subject><subject>Humans</subject><subject>Immune response</subject><subject>Inflammation</subject><subject>Lacrimal gland and Nasolacrimal duct</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Musculoskeletal diseases</subject><subject>Oral Health Impact Profile‐14</subject><subject>Oral hygiene</subject><subject>primary Sjögren's syndrome</subject><subject>Quality of Life</subject><subject>Saliva</subject><subject>Salivary biomarkers</subject><subject>Salivary gland</subject><subject>salivary interleukins</subject><subject>Sjogren's syndrome</subject><subject>Sjogren's Syndrome - diagnosis</subject><subject>Visual Analog Scale for xerostomia</subject><subject>Xerostomia</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1OwzAQhS0EoqWw4AIoEgvEIu34L2mWqOJXlVoJWEdOYoNDEgc7perFuAAXwyWFHbMZjfTNmzcPoVMMY-xrUpp2jCnEsIeGOAIIIcZsHw0hARYSjskAHTlXAuCYMnyIBpRwOmUJDNHyyjmTa9Fp0wRGBU5U-kPYTaAbVYm6Fp3xQ6ZNLeybtC5Y6-41aK2ut9Bj-fX5YmVz4QK3aQpranmMDpSonDzZ9RF6vrl-mt2F88Xt_exqHuaUeIcZj4GpiCYsyzEXSSIjqkhRSAyUE0njCBdRwoGRTGWKcIiLbEqA5kzFgkpJR-i8122teV9J16WlWdnGn0wJ868lESdTT132VG6Nc1aqdGc9xZBus_NbbfqTnWfPdoqrrJbFH_kblgcmPbDWldz8r5Q-LJa95DdVtnk9</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Moreno‐Quispe, Luz A.</creator><creator>Serrano, Julia</creator><creator>Virto, Leire</creator><creator>Sanz, Mariano</creator><creator>Ramírez, Lucía</creator><creator>Fernández‐Castro, Mónica</creator><creator>Hernández, Gonzalo</creator><creator>López‐Pintor, Rosa María</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-5727-0920</orcidid></search><sort><creationdate>202010</creationdate><title>Association of salivary inflammatory biomarkers with primary Sjögren's syndrome</title><author>Moreno‐Quispe, Luz A. ; 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Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><jtitle>Journal of oral pathology &amp; medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreno‐Quispe, Luz A.</au><au>Serrano, Julia</au><au>Virto, Leire</au><au>Sanz, Mariano</au><au>Ramírez, Lucía</au><au>Fernández‐Castro, Mónica</au><au>Hernández, Gonzalo</au><au>López‐Pintor, Rosa María</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of salivary inflammatory biomarkers with primary Sjögren's syndrome</atitle><jtitle>Journal of oral pathology &amp; medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>2020-10</date><risdate>2020</risdate><volume>49</volume><issue>9</issue><spage>940</spage><epage>947</epage><pages>940-947</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Background Primary Sjogren's syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associated with T helper‐2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of interleukin (IL)‐6, IL‐5, and IL‐4 in patients with pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with salivary flow, patient‐reported outcomes (PROMs) for xerostomia and oral health quality of life (Oral Health Impact Profile‐14 [OHIP‐14]), pSS classification criteria and presence of extraglandular manifestations. Methods A case‐control study was conducted in 36 patients with pSS and 35 HCs. Cytokine levels were measured using high‐sensitivity multiplex map human immunoassays. Unstimulated and stimulated whole saliva were collected and patients filled out questionnaires. The Mann‐Whitney U test, chi‐squared test, and Spearman correlation test were used. Results Interleukin‐6 was significantly higher in pSS patients than in HCs (P = .0001). IL‐6 was significantly higher in pSS patients with a positive salivary gland biopsy (P = .04), whole stimulated saliva hyposalivation (P = .02), and presence of musculoskeletal disorders (P = .03). There was a non‐significant positive correlation between IL‐6 levels and PROMs for xerostomia (r = .31; P = .06) and OHIP‐14 (r = .07; P = .68) in pSS patients. Levels of IL‐4 and IL‐5 were not detected in both pSS and HCs patients. Conclusions Salivary IL‐6 levels are significantly associated with pSS patients, and therefore, it is hypothesized that this biomarker may be useful in the diagnosis and follow‐up of this disease.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32538490</pmid><doi>10.1111/jop.13070</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5727-0920</orcidid></addata></record>
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subjects Adaptive immunity
Autoimmune diseases
Biomarkers
Biopsy
Case-Control Studies
Cytokines
Humans
Immune response
Inflammation
Lacrimal gland and Nasolacrimal duct
Lymphocytes
Lymphocytes T
Musculoskeletal diseases
Oral Health Impact Profile‐14
Oral hygiene
primary Sjögren's syndrome
Quality of Life
Saliva
Salivary biomarkers
Salivary gland
salivary interleukins
Sjogren's syndrome
Sjogren's Syndrome - diagnosis
Visual Analog Scale for xerostomia
Xerostomia
title Association of salivary inflammatory biomarkers with primary Sjögren's syndrome
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