Bone glue - The final frontier for fracture repair and implantable device stabilization
The need for a bone adhesive is a challenge that has remained unmet. The concept of a “bone glue” to repair simple and comminuted fractures, as well as to glue orthopaedic devices in place, is considered a holy grail. Today such a product has been developed to satisfy the properties necessary for a...
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Veröffentlicht in: | International journal of adhesion and adhesives 2020-10, Vol.102, p.102647, Article 102647 |
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creator | Norton, Michael R. Kay, George W. Brown, Michael C. Cochran, David L. |
description | The need for a bone adhesive is a challenge that has remained unmet. The concept of a “bone glue” to repair simple and comminuted fractures, as well as to glue orthopaedic devices in place, is considered a holy grail.
Today such a product has been developed to satisfy the properties necessary for a bone adhesive. Its simple chemistry, which is free of cytotoxic or mutagenic effects, reacts in a wet environment and is composed of a multi-phasic mineral-organic biomaterial that forms robust and durable bonds directly to living bone and metallic implants. Over the course of healing, the glue undergoes both evolution and dissolution, allowing bone substitution preserving both the strength of the glue and its volume. In clinical practice, the glue offers the possibility of providing immediate and extended stabilization, eliminating the need for high mechanical bone compression as in press fit or threaded implants and may negate the need for bone plating of fractures. |
doi_str_mv | 10.1016/j.ijadhadh.2020.102647 |
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Today such a product has been developed to satisfy the properties necessary for a bone adhesive. Its simple chemistry, which is free of cytotoxic or mutagenic effects, reacts in a wet environment and is composed of a multi-phasic mineral-organic biomaterial that forms robust and durable bonds directly to living bone and metallic implants. Over the course of healing, the glue undergoes both evolution and dissolution, allowing bone substitution preserving both the strength of the glue and its volume. In clinical practice, the glue offers the possibility of providing immediate and extended stabilization, eliminating the need for high mechanical bone compression as in press fit or threaded implants and may negate the need for bone plating of fractures.</description><identifier>ISSN: 0143-7496</identifier><identifier>EISSN: 1879-0127</identifier><identifier>DOI: 10.1016/j.ijadhadh.2020.102647</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Biomedical materials ; Bone adhesive ; Dental implant stabilization ; Electronic implants ; Fracture fixation ; Fractures ; Orthopedics ; Primary stability ; Repair ; Stabilization ; Surgical implants ; Tetranite</subject><ispartof>International journal of adhesion and adhesives, 2020-10, Vol.102, p.102647, Article 102647</ispartof><rights>2020 The Authors</rights><rights>Copyright Elsevier BV Oct 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-ee355d9c0e86f82c9ac202e4b40d8b1767cc2cc1a6188e34b29fb538503ce3c63</citedby><cites>FETCH-LOGICAL-c388t-ee355d9c0e86f82c9ac202e4b40d8b1767cc2cc1a6188e34b29fb538503ce3c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijadhadh.2020.102647$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Norton, Michael R.</creatorcontrib><creatorcontrib>Kay, George W.</creatorcontrib><creatorcontrib>Brown, Michael C.</creatorcontrib><creatorcontrib>Cochran, David L.</creatorcontrib><title>Bone glue - The final frontier for fracture repair and implantable device stabilization</title><title>International journal of adhesion and adhesives</title><description>The need for a bone adhesive is a challenge that has remained unmet. The concept of a “bone glue” to repair simple and comminuted fractures, as well as to glue orthopaedic devices in place, is considered a holy grail.
Today such a product has been developed to satisfy the properties necessary for a bone adhesive. Its simple chemistry, which is free of cytotoxic or mutagenic effects, reacts in a wet environment and is composed of a multi-phasic mineral-organic biomaterial that forms robust and durable bonds directly to living bone and metallic implants. Over the course of healing, the glue undergoes both evolution and dissolution, allowing bone substitution preserving both the strength of the glue and its volume. In clinical practice, the glue offers the possibility of providing immediate and extended stabilization, eliminating the need for high mechanical bone compression as in press fit or threaded implants and may negate the need for bone plating of fractures.</description><subject>Biomedical materials</subject><subject>Bone adhesive</subject><subject>Dental implant stabilization</subject><subject>Electronic implants</subject><subject>Fracture fixation</subject><subject>Fractures</subject><subject>Orthopedics</subject><subject>Primary stability</subject><subject>Repair</subject><subject>Stabilization</subject><subject>Surgical implants</subject><subject>Tetranite</subject><issn>0143-7496</issn><issn>1879-0127</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkFtLxDAQhYMouK7-BQn43DW3JumbuniDBV9WfAxpOnVTum1NWkF_vVmqz8IMwwxnDpwPoUtKVpRQed2sfGOrXaoVI-xwZFKoI7SgWhUZoUwdowWhgmdKFPIUncXYEEIVEXyB3u76DvB7OwHO8HYHuPadbXEd-m70EHDdpw7WjVMAHGCwPmDbVdjvh9Z2oy1bwBV8egc4ps23_tuOvu_O0Ult2wgXv3OJXh_ut-unbPPy-Ly-3WSOaz1mADzPq8IR0LLWzBXWpQwgSkEqXVIllXPMOWol1Rq4KFlRlznXOeEOuJN8ia5m3yH0HxPE0TT9FFKEaJgQWmrN1UElZ5ULfYwBajMEv7fhy1BiDhBNY_4gmgNEM0NMjzfzI6QMnwmIic5D56DyAdxoqt7_Z_EDyBB9-A</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Norton, Michael R.</creator><creator>Kay, George W.</creator><creator>Brown, Michael C.</creator><creator>Cochran, David L.</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>6I.</scope><scope>AAFTH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope></search><sort><creationdate>202010</creationdate><title>Bone glue - The final frontier for fracture repair and implantable device stabilization</title><author>Norton, Michael R. ; Kay, George W. ; Brown, Michael C. ; Cochran, David L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-ee355d9c0e86f82c9ac202e4b40d8b1767cc2cc1a6188e34b29fb538503ce3c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomedical materials</topic><topic>Bone adhesive</topic><topic>Dental implant stabilization</topic><topic>Electronic implants</topic><topic>Fracture fixation</topic><topic>Fractures</topic><topic>Orthopedics</topic><topic>Primary stability</topic><topic>Repair</topic><topic>Stabilization</topic><topic>Surgical implants</topic><topic>Tetranite</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norton, Michael R.</creatorcontrib><creatorcontrib>Kay, George W.</creatorcontrib><creatorcontrib>Brown, Michael C.</creatorcontrib><creatorcontrib>Cochran, David L.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>International journal of adhesion and adhesives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norton, Michael R.</au><au>Kay, George W.</au><au>Brown, Michael C.</au><au>Cochran, David L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone glue - The final frontier for fracture repair and implantable device stabilization</atitle><jtitle>International journal of adhesion and adhesives</jtitle><date>2020-10</date><risdate>2020</risdate><volume>102</volume><spage>102647</spage><pages>102647-</pages><artnum>102647</artnum><issn>0143-7496</issn><eissn>1879-0127</eissn><abstract>The need for a bone adhesive is a challenge that has remained unmet. The concept of a “bone glue” to repair simple and comminuted fractures, as well as to glue orthopaedic devices in place, is considered a holy grail.
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subjects | Biomedical materials Bone adhesive Dental implant stabilization Electronic implants Fracture fixation Fractures Orthopedics Primary stability Repair Stabilization Surgical implants Tetranite |
title | Bone glue - The final frontier for fracture repair and implantable device stabilization |
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