Pregnant women's preferences for prenatal genetic testing: A single‐center study in Japan

Aim To evaluate how many pregnant women would prefer to undergo prenatal genetic testing (GT) if they received adequate information during early gestation. Methods We examined the preferences for prenatal GT among pregnant women visiting our general outpatient clinic before 16 weeks' gestation...

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Veröffentlicht in:The journal of obstetrics and gynaecology research 2020-10, Vol.46 (10), p.1972-1976
Hauptverfasser: Shibata, Megumi, Akaishi, Rina, Sasaki, Aiko, Ogawa, Kohei, Nishiyama, Miyuki, Wada, Seiji, Ozawa, Nobuaki, Sago, Haruhiko
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container_end_page 1976
container_issue 10
container_start_page 1972
container_title The journal of obstetrics and gynaecology research
container_volume 46
creator Shibata, Megumi
Akaishi, Rina
Sasaki, Aiko
Ogawa, Kohei
Nishiyama, Miyuki
Wada, Seiji
Ozawa, Nobuaki
Sago, Haruhiko
description Aim To evaluate how many pregnant women would prefer to undergo prenatal genetic testing (GT) if they received adequate information during early gestation. Methods We examined the preferences for prenatal GT among pregnant women visiting our general outpatient clinic before 16 weeks' gestation between September 2014 and September 2017. We provided them with informational brochures about prenatal GT at their first visit. Women always received genetic counseling (GC) before undergoing GT of their own choice. Results Among 5700 pregnant women, 2077 (36.4%) received GC, and 1983 (34.8%) underwent some form of prenatal GT. The percentage undergoing GT was 9.4% (50/531) for women
doi_str_mv 10.1111/jog.14381
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Methods We examined the preferences for prenatal GT among pregnant women visiting our general outpatient clinic before 16 weeks' gestation between September 2014 and September 2017. We provided them with informational brochures about prenatal GT at their first visit. Women always received genetic counseling (GC) before undergoing GT of their own choice. Results Among 5700 pregnant women, 2077 (36.4%) received GC, and 1983 (34.8%) underwent some form of prenatal GT. The percentage undergoing GT was 9.4% (50/531) for women &lt;30 years old, 19.0% (309/1623) for those 30–34 years old, 43.1% (989/2294) for those 35–39 years old, and 50.7% (635/1252) for those ≥40 years old. Older pregnant women tended to receive GC and GT more often than younger women (P &lt; 0.001). The most common reason for receiving GC was advanced maternal age (79.7%). The most common prenatal GT was noninvasive prenatal testing (NIPT) (50%), followed by the combined test (29.0%) and quadruple test (11.2%). Pregnant women ≥35 years old tended to choose NIPT (60.5%), while those &lt;35 years old tended to choose the combined test (52.9%). Conclusion About one‐third of the pregnant women preferred to receive prenatal GT by their own choice. Women's preferences for prenatal GT increased with maternal age; however, half of pregnant women with an advanced maternal age preferred not to undergo GT, even if they were well informed.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.14381</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley &amp; Sons Australia, Ltd</publisher><subject>advanced maternal age ; Age ; Genetic counseling ; Genetic screening ; Gestation ; noninvasive prenatal testing ; Pregnancy ; prenatal genetic testing ; trisomy 21 ; Women</subject><ispartof>The journal of obstetrics and gynaecology research, 2020-10, Vol.46 (10), p.1972-1976</ispartof><rights>2020 Japan Society of Obstetrics and Gynecology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3871-2c8ea1fd49e32ed120c642282638f6dc6057ee7c999b48b9a5afff302404e8e53</citedby><cites>FETCH-LOGICAL-c3871-2c8ea1fd49e32ed120c642282638f6dc6057ee7c999b48b9a5afff302404e8e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.14381$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.14381$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Shibata, Megumi</creatorcontrib><creatorcontrib>Akaishi, Rina</creatorcontrib><creatorcontrib>Sasaki, Aiko</creatorcontrib><creatorcontrib>Ogawa, Kohei</creatorcontrib><creatorcontrib>Nishiyama, Miyuki</creatorcontrib><creatorcontrib>Wada, Seiji</creatorcontrib><creatorcontrib>Ozawa, Nobuaki</creatorcontrib><creatorcontrib>Sago, Haruhiko</creatorcontrib><title>Pregnant women's preferences for prenatal genetic testing: A single‐center study in Japan</title><title>The journal of obstetrics and gynaecology research</title><description>Aim To evaluate how many pregnant women would prefer to undergo prenatal genetic testing (GT) if they received adequate information during early gestation. Methods We examined the preferences for prenatal GT among pregnant women visiting our general outpatient clinic before 16 weeks' gestation between September 2014 and September 2017. We provided them with informational brochures about prenatal GT at their first visit. Women always received genetic counseling (GC) before undergoing GT of their own choice. Results Among 5700 pregnant women, 2077 (36.4%) received GC, and 1983 (34.8%) underwent some form of prenatal GT. The percentage undergoing GT was 9.4% (50/531) for women &lt;30 years old, 19.0% (309/1623) for those 30–34 years old, 43.1% (989/2294) for those 35–39 years old, and 50.7% (635/1252) for those ≥40 years old. Older pregnant women tended to receive GC and GT more often than younger women (P &lt; 0.001). The most common reason for receiving GC was advanced maternal age (79.7%). The most common prenatal GT was noninvasive prenatal testing (NIPT) (50%), followed by the combined test (29.0%) and quadruple test (11.2%). Pregnant women ≥35 years old tended to choose NIPT (60.5%), while those &lt;35 years old tended to choose the combined test (52.9%). Conclusion About one‐third of the pregnant women preferred to receive prenatal GT by their own choice. Women's preferences for prenatal GT increased with maternal age; however, half of pregnant women with an advanced maternal age preferred not to undergo GT, even if they were well informed.</description><subject>advanced maternal age</subject><subject>Age</subject><subject>Genetic counseling</subject><subject>Genetic screening</subject><subject>Gestation</subject><subject>noninvasive prenatal testing</subject><subject>Pregnancy</subject><subject>prenatal genetic testing</subject><subject>trisomy 21</subject><subject>Women</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kL9OwzAQxi0EEqUw8AaWGBBDWttxHIetqqBQVSoDTAyR65yjVKkT7FRVNh6BZ-RJcAkrt3x30u-7fwhdUzKhIabbppxQHkt6gkaU8zQiaSJOQx5zGkmSinN04f2WEJpmVI7Q-4uD0irb4UOzA3vrcevAgAOrwWPTuGNtVadqXIKFrtK4A99VtrzHM-yD1vD9-aXBduCw7_ZFjyuLl6pV9hKdGVV7uPrTMXp7fHidP0Wr9eJ5PltFOpYpjZiWoKgpeAYxg4IyogVnTDIRSyMKLUiSAqQ6y7INl5tMJcoYExPGCQcJSTxGN0Pf1jUf-7Bdvm32zoaROeNcJlRwKQN1N1DaNd6HI_PWVTvl-pyS_Pi74Crz398Fdjqwh6qG_n8wX64Xg-MH2pVxVg</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Shibata, Megumi</creator><creator>Akaishi, Rina</creator><creator>Sasaki, Aiko</creator><creator>Ogawa, Kohei</creator><creator>Nishiyama, Miyuki</creator><creator>Wada, Seiji</creator><creator>Ozawa, Nobuaki</creator><creator>Sago, Haruhiko</creator><general>John Wiley &amp; Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>202010</creationdate><title>Pregnant women's preferences for prenatal genetic testing: A single‐center study in Japan</title><author>Shibata, Megumi ; Akaishi, Rina ; Sasaki, Aiko ; Ogawa, Kohei ; Nishiyama, Miyuki ; Wada, Seiji ; Ozawa, Nobuaki ; Sago, Haruhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3871-2c8ea1fd49e32ed120c642282638f6dc6057ee7c999b48b9a5afff302404e8e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>advanced maternal age</topic><topic>Age</topic><topic>Genetic counseling</topic><topic>Genetic screening</topic><topic>Gestation</topic><topic>noninvasive prenatal testing</topic><topic>Pregnancy</topic><topic>prenatal genetic testing</topic><topic>trisomy 21</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shibata, Megumi</creatorcontrib><creatorcontrib>Akaishi, Rina</creatorcontrib><creatorcontrib>Sasaki, Aiko</creatorcontrib><creatorcontrib>Ogawa, Kohei</creatorcontrib><creatorcontrib>Nishiyama, Miyuki</creatorcontrib><creatorcontrib>Wada, Seiji</creatorcontrib><creatorcontrib>Ozawa, Nobuaki</creatorcontrib><creatorcontrib>Sago, Haruhiko</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shibata, Megumi</au><au>Akaishi, Rina</au><au>Sasaki, Aiko</au><au>Ogawa, Kohei</au><au>Nishiyama, Miyuki</au><au>Wada, Seiji</au><au>Ozawa, Nobuaki</au><au>Sago, Haruhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnant women's preferences for prenatal genetic testing: A single‐center study in Japan</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><date>2020-10</date><risdate>2020</risdate><volume>46</volume><issue>10</issue><spage>1972</spage><epage>1976</epage><pages>1972-1976</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim To evaluate how many pregnant women would prefer to undergo prenatal genetic testing (GT) if they received adequate information during early gestation. Methods We examined the preferences for prenatal GT among pregnant women visiting our general outpatient clinic before 16 weeks' gestation between September 2014 and September 2017. We provided them with informational brochures about prenatal GT at their first visit. Women always received genetic counseling (GC) before undergoing GT of their own choice. Results Among 5700 pregnant women, 2077 (36.4%) received GC, and 1983 (34.8%) underwent some form of prenatal GT. The percentage undergoing GT was 9.4% (50/531) for women &lt;30 years old, 19.0% (309/1623) for those 30–34 years old, 43.1% (989/2294) for those 35–39 years old, and 50.7% (635/1252) for those ≥40 years old. Older pregnant women tended to receive GC and GT more often than younger women (P &lt; 0.001). The most common reason for receiving GC was advanced maternal age (79.7%). The most common prenatal GT was noninvasive prenatal testing (NIPT) (50%), followed by the combined test (29.0%) and quadruple test (11.2%). Pregnant women ≥35 years old tended to choose NIPT (60.5%), while those &lt;35 years old tended to choose the combined test (52.9%). Conclusion About one‐third of the pregnant women preferred to receive prenatal GT by their own choice. Women's preferences for prenatal GT increased with maternal age; however, half of pregnant women with an advanced maternal age preferred not to undergo GT, even if they were well informed.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley &amp; Sons Australia, Ltd</pub><doi>10.1111/jog.14381</doi><tpages>5</tpages></addata></record>
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source Wiley Online Library Journals Frontfile Complete
subjects advanced maternal age
Age
Genetic counseling
Genetic screening
Gestation
noninvasive prenatal testing
Pregnancy
prenatal genetic testing
trisomy 21
Women
title Pregnant women's preferences for prenatal genetic testing: A single‐center study in Japan
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