Real-Time Conformational Change Monitoring of G-Quadruplex Using Capillary-Based Biocompatible Whispering Gallery Mode Microresonator

In this paper, a capillary-based microfluidic whispering gallery mode (WGM) microresonator is proposed to dynamically monitor the conformation change of G-quadruplex driven by K + ion. We have theoretically analyzed the resonance wavelength shift mechanism for the DNA folding process, and the resona...

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Veröffentlicht in:	IEEE sensors journal 2020-11, Vol.20 (21), p.12558-12564
Hauptverfasser:	Wang, Yujia, Zhang, Hao, Cui, Yunxi, Lin, Wei, Liu, Bo, Xiang, Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Biological processes Deoxyribonucleic acid DNA DNA computing Folding genetics Immobilization Microcavities Microfluidics Monitoring Optical fiber sensors optical resonators potassium Real time operation Resonance Sensitivity Temperature sensors whispering gallery modes
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