Mitochondria-dependent apoptosis inducer: Testosterone-N4-ethylthiosemicarbazonate and its metal complexes with selective cytotoxicity towards human colorectal carcinoma cell line (HCT 116)

A Schiff base ligand L was prepared from conjugation of testosterone with 4-ethyl-3-thiosemicarbazide and its nickel (C1) and zinc (C2) complex were synthesized. C2 was unable to inhibit the growth of all the cell line tested. However, its parent ligand L and its nickel counterpart C1 were able to i...

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Veröffentlicht in:	Inorganica Chimica Acta 2020-07, Vol.507, p.119581, Article 119581
Hauptverfasser:	Heng, Mok Piew, Tan, Chun Hoe, Saad, Hazwani Mat, Sim, Kae Shin, Tan, Kong Wai
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biotechnology Chemical analysis Colon Conjugation Coordination compounds Crystallography Cytotoxicity DNA interactions Imines Intrinsic pathway Ligands Mitochondria NMR Nuclear magnetic resonance Selectivity Steroidal metal complexes Synthesis Testosterone Testosterone Schiff base Toxicity Zinc compounds
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