Extensive heterogeneity in somatic mutation and selection in the human bladder

The extent of somatic mutation and clonal selection in the human bladder remains unknown. We sequenced 2097 bladder microbiopsies from 20 individuals using targeted ( = 1914 microbiopsies), whole-exome ( = 655), and whole-genome ( = 88) sequencing. We found widespread positive selection in 17 genes....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2020-10, Vol.370 (6512), p.75-82
Hauptverfasser:	Lawson, Andrew R J, Abascal, Federico, Coorens, Tim H H, Hooks, Yvette, O'Neill, Laura, Latimer, Calli, Raine, Keiran, Sanders, Mathijs A, Warren, Anne Y, Mahbubani, Krishnaa T A, Bareham, Bethany, Butler, Timothy M, Harvey, Luke M R, Cagan, Alex, Menzies, Andrew, Moore, Luiza, Colquhoun, Alexandra J, Turner, William, Thomas, Benjamin, Gnanapragasam, Vincent, Williams, Nicholas, Rassl, Doris M, Vöhringer, Harald, Zumalave, Sonia, Nangalia, Jyoti, Tubío, José M C, Gerstung, Moritz, Saeb-Parsy, Kourosh, Stratton, Michael R, Campbell, Peter J, Mitchell, Thomas J, Martincorena, Iñigo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged APOBEC Deaminases - genetics Aristolochic acid Biopsy Bladder Bladder cancer Cancer Carcinogens Chromatin Assembly and Disassembly - genetics Chromatin remodeling Clonal selection Cloning Epithelium Female Gene sequencing Genes Genes, Neoplasm Genomes Heterogeneity Humans Male Middle Aged Mutagenesis Mutagens Mutagens - analysis Mutation Positive selection Selection, Genetic Tobacco Tumors Urinary Bladder - pathology Urinary Bladder Neoplasms - genetics Urinary tract Urothelium Urothelium - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!