Concentration of malondialdehyde-modified low-density lipoprotein in the jugular bulb during carotid endarterectomy correlates with development of postoperative cognitive impairment
Approximately 20 to 30% of patients undergoing carotid endarterectomy (CEA) subsequently develop cognitive impairment. The purpose of the present study is to determine whether or not malondialdehyde (MDA)-modified low-density lipoprotein (LDL), a biochemical marker of oxidative damage, concentration...
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| Veröffentlicht in: | Neurosurgery 2007-06, Vol.60 (6), p.1067-1074 |
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| creator | Saito, Hideo Ogasawara, Kuniaki Komoribayashi, Nobukazu Kobayashi, Masakazu Inoue, Takashi Otawara, Yasunari Ogawa, Akira |
| description | Approximately 20 to 30% of patients undergoing carotid endarterectomy (CEA) subsequently develop cognitive impairment. The purpose of the present study is to determine whether or not malondialdehyde (MDA)-modified low-density lipoprotein (LDL), a biochemical marker of oxidative damage, concentrations in the jugular bulb during CEA correlates with development of postoperative cognitive impairment.
Fifty-five patients undergoing CEA were assessed with a battery of neuropsychological tests before and 1 month after surgery. Serum samples for measurement of MDA-LDL concentration were obtained from a venous catheter inserted into the ipsilateral jugular bulb at the following time points: immediately before clamping of the internal carotid artery (ICA), 10 minutes after clamping of the ICA, and 5 and 20 minutes after declamping of the ICA.
The MDA-LDL concentrations at 5 and 20 minutes after ICA declamping were both significantly higher than concentrations before ICA clamping (P < 0.0001). At the postoperative neuropsychological assessment, six (11%) out of 55 patients showed postoperative cognitive impairment. Logistic regression analysis demonstrated that higher values of MDA-LDL increase (calculated as a percentage of the preclamp values) at either 5 or 20 minutes after ICA declamping were significantly associated with the development of postoperative cognitive impairment (95% confidence interval, 0.787-0.981; P = 0.0209) among the variables tested.
MDA-LDL concentration in the jugular bulb during CEA correlates with development of postoperative cognitive impairment. |
| doi_str_mv | 10.1227/01.NEU.0000255449.74859.C8 |
| format | Article |
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Fifty-five patients undergoing CEA were assessed with a battery of neuropsychological tests before and 1 month after surgery. Serum samples for measurement of MDA-LDL concentration were obtained from a venous catheter inserted into the ipsilateral jugular bulb at the following time points: immediately before clamping of the internal carotid artery (ICA), 10 minutes after clamping of the ICA, and 5 and 20 minutes after declamping of the ICA.
The MDA-LDL concentrations at 5 and 20 minutes after ICA declamping were both significantly higher than concentrations before ICA clamping (P < 0.0001). At the postoperative neuropsychological assessment, six (11%) out of 55 patients showed postoperative cognitive impairment. Logistic regression analysis demonstrated that higher values of MDA-LDL increase (calculated as a percentage of the preclamp values) at either 5 or 20 minutes after ICA declamping were significantly associated with the development of postoperative cognitive impairment (95% confidence interval, 0.787-0.981; P = 0.0209) among the variables tested.
MDA-LDL concentration in the jugular bulb during CEA correlates with development of postoperative cognitive impairment.</description><identifier>ISSN: 0148-396X</identifier><identifier>EISSN: 1524-4040</identifier><identifier>DOI: 10.1227/01.NEU.0000255449.74859.C8</identifier><identifier>PMID: 17538381</identifier><language>eng</language><publisher>United States: Wolters Kluwer Health, Inc</publisher><subject>Aged ; Biomarkers - blood ; Carotid Artery, Internal ; Carotid Stenosis - blood ; Carotid Stenosis - surgery ; Case-Control Studies ; Cognition Disorders - blood ; Cognition Disorders - etiology ; Cognitive ability ; Cohort Studies ; Endarterectomy, Carotid - adverse effects ; Female ; Humans ; Jugular Veins ; Lipoproteins, LDL - blood ; Male ; Malondialdehyde - analogs & derivatives ; Malondialdehyde - blood ; Middle Aged ; Neuropsychological Tests ; Neurosurgery ; Oxidative Stress - physiology ; Time Factors</subject><ispartof>Neurosurgery, 2007-06, Vol.60 (6), p.1067-1074</ispartof><rights>Copyright Oxford University Press Jun 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c244t-5a40ea8e32e590c90f85db4ea4ec91dfd8ce2f96da62b0ec125fbe55e1ccf5693</citedby><cites>FETCH-LOGICAL-c244t-5a40ea8e32e590c90f85db4ea4ec91dfd8ce2f96da62b0ec125fbe55e1ccf5693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17538381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Hideo</creatorcontrib><creatorcontrib>Ogasawara, Kuniaki</creatorcontrib><creatorcontrib>Komoribayashi, Nobukazu</creatorcontrib><creatorcontrib>Kobayashi, Masakazu</creatorcontrib><creatorcontrib>Inoue, Takashi</creatorcontrib><creatorcontrib>Otawara, Yasunari</creatorcontrib><creatorcontrib>Ogawa, Akira</creatorcontrib><title>Concentration of malondialdehyde-modified low-density lipoprotein in the jugular bulb during carotid endarterectomy correlates with development of postoperative cognitive impairment</title><title>Neurosurgery</title><addtitle>Neurosurgery</addtitle><description>Approximately 20 to 30% of patients undergoing carotid endarterectomy (CEA) subsequently develop cognitive impairment. The purpose of the present study is to determine whether or not malondialdehyde (MDA)-modified low-density lipoprotein (LDL), a biochemical marker of oxidative damage, concentrations in the jugular bulb during CEA correlates with development of postoperative cognitive impairment.
Fifty-five patients undergoing CEA were assessed with a battery of neuropsychological tests before and 1 month after surgery. Serum samples for measurement of MDA-LDL concentration were obtained from a venous catheter inserted into the ipsilateral jugular bulb at the following time points: immediately before clamping of the internal carotid artery (ICA), 10 minutes after clamping of the ICA, and 5 and 20 minutes after declamping of the ICA.
The MDA-LDL concentrations at 5 and 20 minutes after ICA declamping were both significantly higher than concentrations before ICA clamping (P < 0.0001). At the postoperative neuropsychological assessment, six (11%) out of 55 patients showed postoperative cognitive impairment. Logistic regression analysis demonstrated that higher values of MDA-LDL increase (calculated as a percentage of the preclamp values) at either 5 or 20 minutes after ICA declamping were significantly associated with the development of postoperative cognitive impairment (95% confidence interval, 0.787-0.981; P = 0.0209) among the variables tested.
MDA-LDL concentration in the jugular bulb during CEA correlates with development of postoperative cognitive impairment.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Carotid Artery, Internal</subject><subject>Carotid Stenosis - blood</subject><subject>Carotid Stenosis - surgery</subject><subject>Case-Control Studies</subject><subject>Cognition Disorders - blood</subject><subject>Cognition Disorders - etiology</subject><subject>Cognitive ability</subject><subject>Cohort Studies</subject><subject>Endarterectomy, Carotid - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Jugular Veins</subject><subject>Lipoproteins, LDL - blood</subject><subject>Male</subject><subject>Malondialdehyde - analogs & derivatives</subject><subject>Malondialdehyde - blood</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Neurosurgery</subject><subject>Oxidative Stress - physiology</subject><subject>Time Factors</subject><issn>0148-396X</issn><issn>1524-4040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFkd2O1CAYhonRuOPqLRiix63QQguemWb9STZ64iaeEQofM0xaqJTuZi7M-5PZnWQJCRw8H-9LHoQ-UFLTpuk_EVr_vLmrSVkN54zJumeCy3oQL9CO8oZVjDDyEu0IZaJqZffnCr1Z1yMhtGO9eI2uaM9b0Qq6Q_-GGAyEnHT2MeDo8KynGKzXk4XDyUI1R-udB4un-FBZCKvPJzz5JS4pZvABl50PgI_bfpt0wuM2jdhuyYc9Nrow3mIIVqcMCUyO8wmbmBJMOsOKH3w-YAv3MMVlLj3ODZa45rjAudI9FHgf_OPNz4v26Uy9Ra-cnlZ4dzmv0d3Xm9_D9-r217cfw5fbyjSM5YprRkALaBvgkhhJnOB2ZKAZGEmts8JA42RnddeMBAxtuBuBc6DGON7J9hp9fHq3_PXvBmtWx7ilUCJVCeh5Lylhhfr8RJkU1zWBU0vys04nRYk6G1OEqmJMPRtTj8bUIMrw-0vENs5gn0cvitr_016adw</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Saito, Hideo</creator><creator>Ogasawara, Kuniaki</creator><creator>Komoribayashi, Nobukazu</creator><creator>Kobayashi, Masakazu</creator><creator>Inoue, Takashi</creator><creator>Otawara, Yasunari</creator><creator>Ogawa, Akira</creator><general>Wolters Kluwer Health, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>200706</creationdate><title>Concentration of malondialdehyde-modified low-density lipoprotein in the jugular bulb during carotid endarterectomy correlates with development of postoperative cognitive impairment</title><author>Saito, Hideo ; Ogasawara, Kuniaki ; Komoribayashi, Nobukazu ; Kobayashi, Masakazu ; Inoue, Takashi ; Otawara, Yasunari ; Ogawa, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c244t-5a40ea8e32e590c90f85db4ea4ec91dfd8ce2f96da62b0ec125fbe55e1ccf5693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Carotid Artery, Internal</topic><topic>Carotid Stenosis - blood</topic><topic>Carotid Stenosis - surgery</topic><topic>Case-Control Studies</topic><topic>Cognition Disorders - blood</topic><topic>Cognition Disorders - etiology</topic><topic>Cognitive ability</topic><topic>Cohort Studies</topic><topic>Endarterectomy, Carotid - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Jugular Veins</topic><topic>Lipoproteins, LDL - blood</topic><topic>Male</topic><topic>Malondialdehyde - analogs & derivatives</topic><topic>Malondialdehyde - blood</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Neurosurgery</topic><topic>Oxidative Stress - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saito, Hideo</creatorcontrib><creatorcontrib>Ogasawara, Kuniaki</creatorcontrib><creatorcontrib>Komoribayashi, Nobukazu</creatorcontrib><creatorcontrib>Kobayashi, Masakazu</creatorcontrib><creatorcontrib>Inoue, Takashi</creatorcontrib><creatorcontrib>Otawara, Yasunari</creatorcontrib><creatorcontrib>Ogawa, Akira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saito, Hideo</au><au>Ogasawara, Kuniaki</au><au>Komoribayashi, Nobukazu</au><au>Kobayashi, Masakazu</au><au>Inoue, Takashi</au><au>Otawara, Yasunari</au><au>Ogawa, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concentration of malondialdehyde-modified low-density lipoprotein in the jugular bulb during carotid endarterectomy correlates with development of postoperative cognitive impairment</atitle><jtitle>Neurosurgery</jtitle><addtitle>Neurosurgery</addtitle><date>2007-06</date><risdate>2007</risdate><volume>60</volume><issue>6</issue><spage>1067</spage><epage>1074</epage><pages>1067-1074</pages><issn>0148-396X</issn><eissn>1524-4040</eissn><abstract>Approximately 20 to 30% of patients undergoing carotid endarterectomy (CEA) subsequently develop cognitive impairment. The purpose of the present study is to determine whether or not malondialdehyde (MDA)-modified low-density lipoprotein (LDL), a biochemical marker of oxidative damage, concentrations in the jugular bulb during CEA correlates with development of postoperative cognitive impairment.
Fifty-five patients undergoing CEA were assessed with a battery of neuropsychological tests before and 1 month after surgery. Serum samples for measurement of MDA-LDL concentration were obtained from a venous catheter inserted into the ipsilateral jugular bulb at the following time points: immediately before clamping of the internal carotid artery (ICA), 10 minutes after clamping of the ICA, and 5 and 20 minutes after declamping of the ICA.
The MDA-LDL concentrations at 5 and 20 minutes after ICA declamping were both significantly higher than concentrations before ICA clamping (P < 0.0001). At the postoperative neuropsychological assessment, six (11%) out of 55 patients showed postoperative cognitive impairment. Logistic regression analysis demonstrated that higher values of MDA-LDL increase (calculated as a percentage of the preclamp values) at either 5 or 20 minutes after ICA declamping were significantly associated with the development of postoperative cognitive impairment (95% confidence interval, 0.787-0.981; P = 0.0209) among the variables tested.
MDA-LDL concentration in the jugular bulb during CEA correlates with development of postoperative cognitive impairment.</abstract><cop>United States</cop><pub>Wolters Kluwer Health, Inc</pub><pmid>17538381</pmid><doi>10.1227/01.NEU.0000255449.74859.C8</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0148-396X |
| ispartof | Neurosurgery, 2007-06, Vol.60 (6), p.1067-1074 |
| issn | 0148-396X 1524-4040 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Aged Biomarkers - blood Carotid Artery, Internal Carotid Stenosis - blood Carotid Stenosis - surgery Case-Control Studies Cognition Disorders - blood Cognition Disorders - etiology Cognitive ability Cohort Studies Endarterectomy, Carotid - adverse effects Female Humans Jugular Veins Lipoproteins, LDL - blood Male Malondialdehyde - analogs & derivatives Malondialdehyde - blood Middle Aged Neuropsychological Tests Neurosurgery Oxidative Stress - physiology Time Factors |
| title | Concentration of malondialdehyde-modified low-density lipoprotein in the jugular bulb during carotid endarterectomy correlates with development of postoperative cognitive impairment |
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