Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage

•Monolithic device with a vertical membrane for mechanical stimulation of tissues.•Actuation unit with 3 individual chambers to apply negative and/or positive pressure.•Real-time tissue imaging at the single cell level: monitoring cell deformation.•Application of healthy and hyper-physiological comp...

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Veröffentlicht in:	Sensors and actuators. B, Chemical Chemical, 2020-07, Vol.315, p.127917, Article 127917
Hauptverfasser:	Paggi, Carlo Alberto, Venzac, Bastien, Karperien, Marcel, Leijten, Jeroen C.H., Le Gac, Séverine
Format:	Artikel
Sprache:	eng
Schlagworte:	Actuation Cartilage Cell-laden hydrogel Chambers Compression tests Deflection Design optimization Design parameters Hydrogels Mechanical actuation Membranes Microfluidics Polydimethylsiloxane Stimulation
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