Titanium dioxide nanoparticle genotoxicity: A review of recent in vivo and in vitro studies
Titanium dioxide nanoparticles (TiO2 NPs, size
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Veröffentlicht in: | Toxicology and Industrial Health 2020-07, Vol.36 (7), p.514-530 |
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container_title | Toxicology and Industrial Health |
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creator | Wani, Mohammad Rafiq Shadab, GGHA |
description | Titanium dioxide nanoparticles (TiO2 NPs, size |
doi_str_mv | 10.1177/0748233720936835 |
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Studies have found that exposure to TiO2 NPs can cause inflammation, cytotoxicity, genotoxicity and cell apoptosis. In this article, we have reviewed the recent literature on the potential of TiO2 NPs to cause genotoxicity and summarized the results of two standard genotoxicity assays, the comet and micronucleus (MN) assays. Analysis of these peer-reviewed publications shows that the comet assay is the most common genotoxicity test, followed by MN, Ames, and chromosome aberration tests. These assays have reported positive as well as negative results, although there is inconsistency in some results that need to be confirmed further by well-designed experiments. 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We also discuss the possible mechanisms of TiO2 NP genotoxicity and point out areas that warrant further research.</description><subject>Apoptosis</subject><subject>Bioassays</subject><subject>Biocompatibility</subject><subject>Chromosomes</subject><subject>Comet assay</subject><subject>Cosmetics</subject><subject>Cytotoxicity</subject><subject>Damage detection</subject><subject>Food production</subject><subject>Genotoxicity</subject><subject>In vivo methods and tests</subject><subject>Nanoparticles</subject><subject>Oxidative stress</subject><subject>Reviews</subject><subject>Titanium</subject><subject>Titanium dioxide</subject><subject>Toxicity</subject><issn>0748-2337</issn><issn>1477-0393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1UE1LAzEQDaJgrd49BjyvZpNNsvFWil9Q8FJPHpY0mZSUNqlJWu2_d8sKguBl5jHvY-AhdF2T27qW8o7IpqWMSUoUEy3jJ2hUN1JWhCl2ikZHujry5-gi5xUhRAhOR-h97osOfrfB1scvbwEHHeJWp-LNGvASQiz93fhyuMcTnGDv4RNH1yMDoWAf8N7vI9bBDrikiHPZWQ_5Ep05vc5w9bPH6O3xYT59rmavTy_TyawylMvSz4VhRC6YbRThIBatZdIRMEI6DrY1SjKnNG9bQYl0snEWDKGiv2glDWdjdDPkblP82EEu3SruUuhfdrRpOFUNFapXkUFlUsw5geu2yW90OnQ16Y4Vdn8r7C3VYMl6Cb-h_-q_Ad7TcR4</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Wani, Mohammad Rafiq</creator><creator>Shadab, GGHA</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T2</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><orcidid>https://orcid.org/0000-0002-9845-3758</orcidid><orcidid>https://orcid.org/0000-0001-5183-6041</orcidid></search><sort><creationdate>202007</creationdate><title>Titanium dioxide nanoparticle genotoxicity: A review of recent in vivo and in vitro studies</title><author>Wani, Mohammad Rafiq ; 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subjects | Apoptosis Bioassays Biocompatibility Chromosomes Comet assay Cosmetics Cytotoxicity Damage detection Food production Genotoxicity In vivo methods and tests Nanoparticles Oxidative stress Reviews Titanium Titanium dioxide Toxicity |
title | Titanium dioxide nanoparticle genotoxicity: A review of recent in vivo and in vitro studies |
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