Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is resistant to virtually all chemo‐ and targeted therapeutic approaches. Epigenetic regulators represent a novel class of drug targets. Among them, BET and HDAC proteins are central regulators of chromatin structure and transcription, and preclinical evidence...

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Veröffentlicht in:	International journal of cancer 2020-11, Vol.147 (10), p.2847-2861
Hauptverfasser:	Zhang, Xin, Zegar, Tim, Weiser, Tim, Hamdan, Feda H., Berger, Benedict‐Tilman, Lucas, Romain, Balourdas, Dimitrios‐IIias, Ladigan, Swetlana, Cheung, Phyllis F., Liffers, Sven‐Thorsten, Trajkovic‐Arsic, Marija, Scheffler, Bjoern, Joerger, Andreas C., Hahn, Stephan A., Johnsen, Steven A., Knapp, Stefan, Siveke, Jens T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Antineoplastic Agents - pharmacology Antitumor activity Azepines - chemistry BET inhibitor Cancer Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Cell Cycle Proteins - chemistry Cell Cycle Proteins - metabolism Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chromatin combined therapy Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology DNA microarrays Drug Synergism dual BET/HDAC inhibitor Epigenesis, Genetic - drug effects Gemcitabine Gene Expression Regulation, Neoplastic - drug effects HDAC inhibitor Histone deacetylase Histone Deacetylase 1 - antagonists & inhibitors Histone Deacetylase Inhibitors - pharmacology Humans Medical research Pancreas Pancreatic cancer pancreatic ductal adenocarcinoma Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Protein Domains - drug effects Proto-Oncogene Proteins c-fos - genetics Therapeutic targets Transcription Transcription Factors - chemistry Transcription Factors - metabolism Triazoles - chemistry
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