ROS-dependent inhibition of the PI3K/Akt/mTOR signaling is required for Oroxylin A to exert anti-inflammatory activity in liver fibrosis

[Display omitted] •Oroxylin A decreased the release of inflammatory factors in HSCs.•Oroxylin A exerted anti-inflammatory effect through PI3K/Akt/mTOR signaling.•Oroxylin A exerted anti-inflammatory activity by scavenging ROS in HSCs. More and more evidence showed that autophagy is an inflammation-r...

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Veröffentlicht in:	International immunopharmacology 2020-08, Vol.85, p.106637, Article 106637
Hauptverfasser:	Shen, Min, Guo, Mei, Wang, Zhenyi, Li, Yujia, Kong, Desong, Shao, Jiangjuan, Tan, Shanzhong, Chen, Anping, Zhang, Feng, Zhang, Zili, Zheng, Shizhong
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activation AKT protein Animals Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Autophagy Bile Buthionine sulfoximine Carbon Tetrachloride Cells, Cultured Chemotherapy Cytokines Cytokines - genetics Drug therapy Fibrosis Flavonoids - pharmacology Flavonoids - therapeutic use Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Inflammation Liver Liver Cirrhosis - chemically induced Liver Cirrhosis - drug therapy Liver Cirrhosis - metabolism Liver diseases Liver fibrosis Male Mice, Inbred C57BL Oroxylin A Phagocytosis Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt/mTOR signaling Proto-Oncogene Proteins c-akt - genetics Reactive oxygen species Reactive Oxygen Species - metabolism ROS Scavenging Signal Transduction - drug effects Signaling Target recognition TOR protein TOR Serine-Threonine Kinases - genetics
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