Benzophenone-3 and benzophenone-8 exhibit obesogenic activity via peroxisome proliferator-activated receptor γ pathway

Benzophenone-3 (BP-3) and benzopenone-8 (BP-8) are commonly used ultraviolet (UV) filter ingredients in diverse sunscreen products. Recently, the obesogenic activity of avobenzone, a long wave UV A filter, was elucidated in the adipogenesis model of human bone marrow mesenchymal stem cells (hBM-MSCs...

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Veröffentlicht in:	Toxicology in vitro 2020-09, Vol.67, p.104886, Article 104886
Hauptverfasser:	Shin, Jeayoung C., Lee, Eunyoung, An, Seungchan, Jin, Sun Hee, Ha, Jaehyoun, Choi, Won Jun, Noh, Minsoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis Adipogenesis - drug effects Adiponectin Agonists Benzophenone Benzophenone-3 Benzophenone-8 Benzophenones - toxicity Bisphenols Bone marrow Cells, Cultured Chemical fingerprinting Human bone marrow mesenchymal stem cells Humans Keratinocytes Lipid metabolism Lipids Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Mesenchyme Obesity Obesogen PPAR gamma - agonists PPAR gamma - genetics PPAR gamma - metabolism PPARγ Receptors Signal Transduction Stem cells Steroids Sun screens Sunscreening Agents - toxicity Target recognition Transcription Ultraviolet filters
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