Surface plasmon resonance biosensor for the detection of tau-amyloid β complex

•New biosensor for the prospective AD biomarker - the complex of protein tau and Aβ.•The method enables the detection of the tau-Aβ complex in CSF down to sub-pM levels.•First reported sensor-based measurement of the levels of tau-Aβ complex in CSF samples. The development of methods advancing the u...

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Veröffentlicht in:	Sensors and actuators. B, Chemical Chemical, 2020-08, Vol.316, p.128146, Article 128146
Hauptverfasser:	Špringer, Tomáš, Hemmerová, Erika, Finocchiaro, Giusy, Krištofiková, Zdenka, Vyhnálek, Martin, Homola, Jiří
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Biomarker complex of protein tau and amyloid β Biomarkers Biosensors Cerebrospinal fluid Detection Gold Gold nanoparticles Nanoparticles Surface plasmon resonance Surface plasmon resonance (SPR) biosensor
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