DNA methyltransferase inhibitor alleviates bleomycin-induced pulmonary inflammation

•The severity of bleomycin-induced acute lung injury is relieved by 5-azacytidine.•Mice with 5-azacytidine treatment show reduced cell infiltration into the lungs.•Lungs of 5-azacytidine-treated mice show decreased inflammatory cytokine expression. Acute lung injury (ALI) is a severe disease charact...

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Veröffentlicht in:	International immunopharmacology 2020-07, Vol.84, p.106542, Article 106542
Hauptverfasser:	Lu, Chun-Hao, Chen, Chun-Ming, Ma, Jason, Wu, Cheng-Jang, Chen, Li-Chen, Kuo, Ming-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lung inflammation Acute Lung Injury - blood Acute Lung Injury - chemically induced Acute Lung Injury - drug therapy Acute Lung Injury - immunology Alveoli Animal models Animals Antibiotics, Antineoplastic - adverse effects Azacitidine - therapeutic use Azacytidine Bleomycin Bleomycin - adverse effects Blood cells Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Bronchus Cytokines Cytokines - genetics Cytokines - immunology Deoxyribonucleic acid DNA DNA methyltransferase DNA methyltransferase inhibitor DNA Modification Methylases - antagonists & inhibitors Female Fibrosis Gene expression Inflammation Inflammation - blood Inflammation - chemically induced Inflammation - drug therapy Inflammation - immunology Inhibitors Leukocyte Count Leukocytes Lung - drug effects Lung - immunology Lung - pathology Lungs Mice, Inbred C57BL Monocyte chemoattractant protein 1 Neutrophilia Neutrophils Pulmonary inflammation Trachea
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