Autophagy in fibroblasts induced by cigarette smoke extract promotes invasion in lung cancer cells

We investigated the effects of cigarette smoke extract (CSE) on lung fibroblasts and found that the invasiveness of lung cancer cells was facilitated by the conditioned medium from CSE‐treated fibroblasts. CSE induced autophagy in fibroblasts and increased the expression of autophagy‐related protein...

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Veröffentlicht in:	International journal of cancer 2020-11, Vol.147 (9), p.2587-2596
Hauptverfasser:	Hou, Hsin‐Han, Pan, Huei‐Jyuan, Liao, Wei‐Yu, Lee, Chau‐Hwang, Yu, Chong‐Jen
Format:	Artikel
Sprache:	eng
Schlagworte:	3D invasion assay Autophagy Autophagy - drug effects Autophagy - immunology autophagy in tumor microenvironment Cancer Cancer-Associated Fibroblasts - drug effects Cancer-Associated Fibroblasts - immunology Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - pathology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Movement - drug effects Cigarette smoke Culture Media, Conditioned - metabolism Fibroblasts fibroblast‐led invasion Gene Knockdown Techniques Humans Interleukin-8 - metabolism interleukin‐8 Invasiveness Lung - cytology Lung - pathology Lung cancer Lung Neoplasms - immunology Lung Neoplasms - pathology Medical research Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Neoplasm Invasiveness - pathology Nicotiana - adverse effects p62 Protein Phagocytosis Proteins rab1 GTP-Binding Proteins - genetics rab1 GTP-Binding Proteins - metabolism Smoke - adverse effects Smoking - adverse effects Smoking - immunology Spheroids Spheroids, Cellular Tobacco smoke Tumor Microenvironment - drug effects Tumor Microenvironment - immunology
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