Increasing protein stability by engineering the n → π interaction at the β-turn

Abundant n → π* interactions between adjacent backbone carbonyl groups, identified by statistical analysis of protein structures, are predicted to play an important role in dictating the structure of proteins. However, experimentally testing the prediction in proteins has been challenging due to the...

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Veröffentlicht in:	Chemical science (Cambridge) 2020-09, Vol.11 (35), p.948-9487
Hauptverfasser:	Khatri, Bhavesh, Majumder, Puja, Nagesh, Jayashree, Penmatsa, Aravind, Chatterjee, Jayanta
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbonyl groups Carbonyls Chemistry Crystal structure Crystallography Molecular conformation Proteins Statistical analysis Structural stability
Online-Zugang:	Volltext
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