Specific glioblastoma multiforme prognostic-subtype distinctions based on DNA methylation patterns

DNA methylation is an important regulator of gene expression, and plays a significant role in carcinogenesis in the brain. Here, we explored specific prognosis-subtypes based on DNA methylation status using 138 Glioblastoma Multiforme (GBM) samples from The Cancer Genome Atlas (TCGA) database. The m...

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Veröffentlicht in:	Cancer gene therapy 2020-09, Vol.27 (9), p.702-714
Hauptverfasser:	Ma, Huihui, Zhao, Chenggang, Zhao, Zhiyang, Hu, Lizhu, Ye, Fang, Wang, Hongzhi, Fang, Zhiyou, Wu, Yuejin, Chen, Xueran
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 38/47 631/208/69 631/67/1922 692/53 Biomedical and Life Sciences Biomedicine Brain cancer Brain Neoplasms - genetics Brain Neoplasms - mortality Carcinogenesis Cell migration CpG islands Deoxyribonucleic acid DNA DNA methylation DNA Methylation - genetics Epigenetic inheritance Female Gene Expression Gene Therapy Genetic aspects Genomes Glioblastoma Glioblastoma - genetics Glioblastoma - mortality Glioblastoma multiforme Health aspects Humans Male Medical prognosis Methylation Prognosis Radiation therapy Survival Analysis Temozolomide
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