Gelatin–rosin gum complex nanoparticles: preparation, characterization and colon targeted delivery of 5-fluorouracil
Gelatin-rosin gum complex nanoparticles (GGR NPs ) have been synthesized by complex coacervation method. The particles were extensively characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and particle size...
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| Veröffentlicht in: | Chemical papers 2020-12, Vol.74 (12), p.4241-4252 |
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| creator | Joshi, Sneha Singh, Vandana |
| description | Gelatin-rosin gum complex nanoparticles (GGR
NPs
) have been synthesized by complex coacervation method. The particles were extensively characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and particle size analysis based on dynamic light scattering (DLS). The GGR
NP3
were stable and their average particle size was ~ 153 nm. GGR
NPs
were evaluated as the carrier matrix for 5-fluoro uracil (5-FU), and the release behavior of 5-FU was examined by swelling and in vitro dissolution tests in simulated gastrointestinal fluid (SGF) for first 2 h followed by 14 h in simulated intestinal fluid (SIF). About 71% drug release was witnessed (SGF = 21%; SIF = 50%) over a time span of 16 h, in contrast to native gelatin or rosin gum where under identical conditions the release exhausted within 7 h and 10 h, respectively. The release profile followed the first-order kinetics and the diffusion exponent (
n
) values obtained from the Korsemeyer−Peppas model ranged between 0.5 |
| doi_str_mv | 10.1007/s11696-020-01231-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2441968554</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2441968554</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-3f7ed6dd202db5f2a25bf41fa5bd4ffcd519ddb512fb75e746cbed2e1098eb833</originalsourceid><addsrcrecordid>eNp9kE1OwzAQRi0EElXpBVhZYovB_0nYoQoKUiU2sLaceFyC0iTYaUVZcQduyEkwDRI7Vh6PvzdjPYROGb1glGaXkTFdaEI5JZRxwQg9QBMmhCYFzdQhmnCVK5Lxgh6jWYx1SaXMBM91NkHbBTR2qNuvj8_QxbrFq80aV926b-ANt7btehuGumogXuE-QLqldNee4-o5ldUAoX7fd7BtXQKbVA02rGAAhx009RbCDnceK-KbTRe6TaLq5gQdedtEmP2eU_R0e_M4vyPLh8X9_HpJKqH0QITPwGnnOOWuVJ5brkovmbeqdNL7yilWuPTCuC8zBZnUVQmOA6NFDmUuxBSdjXP70L1uIA7mJf2gTSsNl5IVOldKphQfU1VyEAN404d6bcPOMGp-FJtRsUmKzV6xoQkSIxRTuF1B-Bv9D_UNQauDUQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2441968554</pqid></control><display><type>article</type><title>Gelatin–rosin gum complex nanoparticles: preparation, characterization and colon targeted delivery of 5-fluorouracil</title><source>SpringerLink Journals</source><creator>Joshi, Sneha ; Singh, Vandana</creator><creatorcontrib>Joshi, Sneha ; Singh, Vandana</creatorcontrib><description>Gelatin-rosin gum complex nanoparticles (GGR
NPs
) have been synthesized by complex coacervation method. The particles were extensively characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and particle size analysis based on dynamic light scattering (DLS). The GGR
NP3
were stable and their average particle size was ~ 153 nm. GGR
NPs
were evaluated as the carrier matrix for 5-fluoro uracil (5-FU), and the release behavior of 5-FU was examined by swelling and in vitro dissolution tests in simulated gastrointestinal fluid (SGF) for first 2 h followed by 14 h in simulated intestinal fluid (SIF). About 71% drug release was witnessed (SGF = 21%; SIF = 50%) over a time span of 16 h, in contrast to native gelatin or rosin gum where under identical conditions the release exhausted within 7 h and 10 h, respectively. The release profile followed the first-order kinetics and the diffusion exponent (
n
) values obtained from the Korsemeyer−Peppas model ranged between 0.5 <
n
< 0.8 (both in SGF and SIF), which indicated non-Fickian diffusion mechanism. A549 cell line was used to carry out MTT assay test for investigating the cell toxicity of the drug-loaded GGR
NP3
(D GGR
NP3
) where DGGR
NP3
exhibited greater toxicity as compared to GGR
NP3
.
Graphic abstract</description><identifier>ISSN: 2585-7290</identifier><identifier>ISSN: 0366-6352</identifier><identifier>EISSN: 1336-9075</identifier><identifier>DOI: 10.1007/s11696-020-01231-0</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Biochemistry ; Biotechnology ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Colon ; Computer simulation ; Drug delivery systems ; Emission analysis ; Field emission microscopy ; Fourier transforms ; Gelatin ; Industrial Chemistry/Chemical Engineering ; Materials Science ; Medicinal Chemistry ; Nanoparticles ; Original Paper ; Particle size ; Photon correlation spectroscopy ; Rosin ; Toxicity ; Uracil</subject><ispartof>Chemical papers, 2020-12, Vol.74 (12), p.4241-4252</ispartof><rights>Institute of Chemistry, Slovak Academy of Sciences 2020</rights><rights>Institute of Chemistry, Slovak Academy of Sciences 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-3f7ed6dd202db5f2a25bf41fa5bd4ffcd519ddb512fb75e746cbed2e1098eb833</citedby><cites>FETCH-LOGICAL-c356t-3f7ed6dd202db5f2a25bf41fa5bd4ffcd519ddb512fb75e746cbed2e1098eb833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11696-020-01231-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11696-020-01231-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Joshi, Sneha</creatorcontrib><creatorcontrib>Singh, Vandana</creatorcontrib><title>Gelatin–rosin gum complex nanoparticles: preparation, characterization and colon targeted delivery of 5-fluorouracil</title><title>Chemical papers</title><addtitle>Chem. Pap</addtitle><description>Gelatin-rosin gum complex nanoparticles (GGR
NPs
) have been synthesized by complex coacervation method. The particles were extensively characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and particle size analysis based on dynamic light scattering (DLS). The GGR
NP3
were stable and their average particle size was ~ 153 nm. GGR
NPs
were evaluated as the carrier matrix for 5-fluoro uracil (5-FU), and the release behavior of 5-FU was examined by swelling and in vitro dissolution tests in simulated gastrointestinal fluid (SGF) for first 2 h followed by 14 h in simulated intestinal fluid (SIF). About 71% drug release was witnessed (SGF = 21%; SIF = 50%) over a time span of 16 h, in contrast to native gelatin or rosin gum where under identical conditions the release exhausted within 7 h and 10 h, respectively. The release profile followed the first-order kinetics and the diffusion exponent (
n
) values obtained from the Korsemeyer−Peppas model ranged between 0.5 <
n
< 0.8 (both in SGF and SIF), which indicated non-Fickian diffusion mechanism. A549 cell line was used to carry out MTT assay test for investigating the cell toxicity of the drug-loaded GGR
NP3
(D GGR
NP3
) where DGGR
NP3
exhibited greater toxicity as compared to GGR
NP3
.
Graphic abstract</description><subject>Biochemistry</subject><subject>Biotechnology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Colon</subject><subject>Computer simulation</subject><subject>Drug delivery systems</subject><subject>Emission analysis</subject><subject>Field emission microscopy</subject><subject>Fourier transforms</subject><subject>Gelatin</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Materials Science</subject><subject>Medicinal Chemistry</subject><subject>Nanoparticles</subject><subject>Original Paper</subject><subject>Particle size</subject><subject>Photon correlation spectroscopy</subject><subject>Rosin</subject><subject>Toxicity</subject><subject>Uracil</subject><issn>2585-7290</issn><issn>0366-6352</issn><issn>1336-9075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1OwzAQRi0EElXpBVhZYovB_0nYoQoKUiU2sLaceFyC0iTYaUVZcQduyEkwDRI7Vh6PvzdjPYROGb1glGaXkTFdaEI5JZRxwQg9QBMmhCYFzdQhmnCVK5Lxgh6jWYx1SaXMBM91NkHbBTR2qNuvj8_QxbrFq80aV926b-ANt7btehuGumogXuE-QLqldNee4-o5ldUAoX7fd7BtXQKbVA02rGAAhx009RbCDnceK-KbTRe6TaLq5gQdedtEmP2eU_R0e_M4vyPLh8X9_HpJKqH0QITPwGnnOOWuVJ5brkovmbeqdNL7yilWuPTCuC8zBZnUVQmOA6NFDmUuxBSdjXP70L1uIA7mJf2gTSsNl5IVOldKphQfU1VyEAN404d6bcPOMGp-FJtRsUmKzV6xoQkSIxRTuF1B-Bv9D_UNQauDUQ</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Joshi, Sneha</creator><creator>Singh, Vandana</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20201201</creationdate><title>Gelatin–rosin gum complex nanoparticles: preparation, characterization and colon targeted delivery of 5-fluorouracil</title><author>Joshi, Sneha ; Singh, Vandana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-3f7ed6dd202db5f2a25bf41fa5bd4ffcd519ddb512fb75e746cbed2e1098eb833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biochemistry</topic><topic>Biotechnology</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Colon</topic><topic>Computer simulation</topic><topic>Drug delivery systems</topic><topic>Emission analysis</topic><topic>Field emission microscopy</topic><topic>Fourier transforms</topic><topic>Gelatin</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Materials Science</topic><topic>Medicinal Chemistry</topic><topic>Nanoparticles</topic><topic>Original Paper</topic><topic>Particle size</topic><topic>Photon correlation spectroscopy</topic><topic>Rosin</topic><topic>Toxicity</topic><topic>Uracil</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joshi, Sneha</creatorcontrib><creatorcontrib>Singh, Vandana</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical papers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joshi, Sneha</au><au>Singh, Vandana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gelatin–rosin gum complex nanoparticles: preparation, characterization and colon targeted delivery of 5-fluorouracil</atitle><jtitle>Chemical papers</jtitle><stitle>Chem. Pap</stitle><date>2020-12-01</date><risdate>2020</risdate><volume>74</volume><issue>12</issue><spage>4241</spage><epage>4252</epage><pages>4241-4252</pages><issn>2585-7290</issn><issn>0366-6352</issn><eissn>1336-9075</eissn><abstract>Gelatin-rosin gum complex nanoparticles (GGR
NPs
) have been synthesized by complex coacervation method. The particles were extensively characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and particle size analysis based on dynamic light scattering (DLS). The GGR
NP3
were stable and their average particle size was ~ 153 nm. GGR
NPs
were evaluated as the carrier matrix for 5-fluoro uracil (5-FU), and the release behavior of 5-FU was examined by swelling and in vitro dissolution tests in simulated gastrointestinal fluid (SGF) for first 2 h followed by 14 h in simulated intestinal fluid (SIF). About 71% drug release was witnessed (SGF = 21%; SIF = 50%) over a time span of 16 h, in contrast to native gelatin or rosin gum where under identical conditions the release exhausted within 7 h and 10 h, respectively. The release profile followed the first-order kinetics and the diffusion exponent (
n
) values obtained from the Korsemeyer−Peppas model ranged between 0.5 <
n
< 0.8 (both in SGF and SIF), which indicated non-Fickian diffusion mechanism. A549 cell line was used to carry out MTT assay test for investigating the cell toxicity of the drug-loaded GGR
NP3
(D GGR
NP3
) where DGGR
NP3
exhibited greater toxicity as compared to GGR
NP3
.
Graphic abstract</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s11696-020-01231-0</doi><tpages>12</tpages></addata></record> |
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| ispartof | Chemical papers, 2020-12, Vol.74 (12), p.4241-4252 |
| issn | 2585-7290 0366-6352 1336-9075 |
| language | eng |
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| source | SpringerLink Journals |
| subjects | Biochemistry Biotechnology Chemistry Chemistry and Materials Science Chemistry/Food Science Colon Computer simulation Drug delivery systems Emission analysis Field emission microscopy Fourier transforms Gelatin Industrial Chemistry/Chemical Engineering Materials Science Medicinal Chemistry Nanoparticles Original Paper Particle size Photon correlation spectroscopy Rosin Toxicity Uracil |
| title | Gelatin–rosin gum complex nanoparticles: preparation, characterization and colon targeted delivery of 5-fluorouracil |
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