Validation of an analytical method for the simultaneous determination of 16 drugs and metabolites in hair in the context of driving license granting

•A fast UHPLC–MS/MS method for multi-analytes hair analysis was developed and validated.•The measurement uncertainty in multi-analytes hair analysis was demonstrated•Twelve percent of injured drivers tested positive for drug abuse by hair analysis•Hair analysis can identify retrospective drug abuse....

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Veröffentlicht in:Forensic science international 2020-10, Vol.315, p.110428, Article 110428
Hauptverfasser: Müller, Victoria Vendramini, Hahn, Roberta Zilles, Lizot, Lilian de Lima Feltraco, Schneider, Anelise, da Silva, Cristiane Pereira, Gerbase, Fernando Engel, Pereira, Danilo, Linden, Rafael, Antunes, Marina Venzon
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container_title Forensic science international
container_volume 315
creator Müller, Victoria Vendramini
Hahn, Roberta Zilles
Lizot, Lilian de Lima Feltraco
Schneider, Anelise
da Silva, Cristiane Pereira
Gerbase, Fernando Engel
Pereira, Danilo
Linden, Rafael
Antunes, Marina Venzon
description •A fast UHPLC–MS/MS method for multi-analytes hair analysis was developed and validated.•The measurement uncertainty in multi-analytes hair analysis was demonstrated•Twelve percent of injured drivers tested positive for drug abuse by hair analysis•Hair analysis can identify retrospective drug abuse. The use of psychoactive substances has been associated with increased risk for traffic accidents. Hair testing has become a routine practice in clinical and forensic toxicological laboratories, with a unique perspective in the investigation of drug consumption. The study aimed to develop and validate a UHPLC-MS/MS method for the determination of multiple drugs in hair, to be used for toxicological examination in driving license granting. Sample preparation was a one-step liquid extraction of milled hair with methanol, which was incubated for 15h at 50°C. The chromatographic separation was performed in a reversed phase column, with a run time of 2.2min. Measured compounds were cocaine, benzoylecgonine, norcocaine, anhydroecgonine methyl ester, cocaethylene, amphetamine, methamphetamine, methylenedioxyamphetamine, methylenedioxymethamphetamine, fenproporex, amfepramone, mazindol, codeine, morphine, 6-monoacetylmorphine, and tetrahydrocannabinol. The assay was linear for all substances (r>0.99), accurate (86.63–105.87 %), and precise, with a cv ranging from 1.9–13.5 % for intra-assay and 3.3–14.3 % for inter-assay. There was no significant carry over effect and the internal standard corrected matrix effect was minimal. The relative uncertainty percentages were below 9% for all the substances at cut-off values. The method was successfully applied to 50 hair samples from injured drivers, with 12% of positivity, including cocaine, MDMA and THC.
doi_str_mv 10.1016/j.forsciint.2020.110428
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The use of psychoactive substances has been associated with increased risk for traffic accidents. Hair testing has become a routine practice in clinical and forensic toxicological laboratories, with a unique perspective in the investigation of drug consumption. The study aimed to develop and validate a UHPLC-MS/MS method for the determination of multiple drugs in hair, to be used for toxicological examination in driving license granting. Sample preparation was a one-step liquid extraction of milled hair with methanol, which was incubated for 15h at 50°C. The chromatographic separation was performed in a reversed phase column, with a run time of 2.2min. Measured compounds were cocaine, benzoylecgonine, norcocaine, anhydroecgonine methyl ester, cocaethylene, amphetamine, methamphetamine, methylenedioxyamphetamine, methylenedioxymethamphetamine, fenproporex, amfepramone, mazindol, codeine, morphine, 6-monoacetylmorphine, and tetrahydrocannabinol. 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The use of psychoactive substances has been associated with increased risk for traffic accidents. Hair testing has become a routine practice in clinical and forensic toxicological laboratories, with a unique perspective in the investigation of drug consumption. The study aimed to develop and validate a UHPLC-MS/MS method for the determination of multiple drugs in hair, to be used for toxicological examination in driving license granting. Sample preparation was a one-step liquid extraction of milled hair with methanol, which was incubated for 15h at 50°C. The chromatographic separation was performed in a reversed phase column, with a run time of 2.2min. Measured compounds were cocaine, benzoylecgonine, norcocaine, anhydroecgonine methyl ester, cocaethylene, amphetamine, methamphetamine, methylenedioxyamphetamine, methylenedioxymethamphetamine, fenproporex, amfepramone, mazindol, codeine, morphine, 6-monoacetylmorphine, and tetrahydrocannabinol. 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The use of psychoactive substances has been associated with increased risk for traffic accidents. Hair testing has become a routine practice in clinical and forensic toxicological laboratories, with a unique perspective in the investigation of drug consumption. The study aimed to develop and validate a UHPLC-MS/MS method for the determination of multiple drugs in hair, to be used for toxicological examination in driving license granting. Sample preparation was a one-step liquid extraction of milled hair with methanol, which was incubated for 15h at 50°C. The chromatographic separation was performed in a reversed phase column, with a run time of 2.2min. Measured compounds were cocaine, benzoylecgonine, norcocaine, anhydroecgonine methyl ester, cocaethylene, amphetamine, methamphetamine, methylenedioxyamphetamine, methylenedioxymethamphetamine, fenproporex, amfepramone, mazindol, codeine, morphine, 6-monoacetylmorphine, and tetrahydrocannabinol. 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subjects Accreditation
Amphetamines
Assaying
Automobile Driving
Chromatography, High Pressure Liquid
Cocaethylene
Cocaine
Codeine
Criminal investigations
Driving ability
driving license
Drug abuse
Drugs
Drugs of abuse
Ecstasy
Forensic science
Forensic sciences
Hair
Hair - chemistry
Hair analysis
Humans
Illicit Drugs - analysis
Licensure
Limit of Detection
Mass Spectrometry
MDMA
Metabolites
Methamphetamine
Methods
Morphine
Occupant injuries
Psychotropic Drugs - analysis
Quality control
Quality standards
Sample preparation
Substance Abuse Detection - methods
Substance-Related Disorders - diagnosis
Tetrahydrocannabinol
THC
Toxicological analysis
Traffic
Traffic accidents
Traffic accidents & safety
UHPLC-MS/MS
title Validation of an analytical method for the simultaneous determination of 16 drugs and metabolites in hair in the context of driving license granting
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