FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages

FTY720 is a treatment for relapsing remitting multiple sclerosis (MS). It is an analog of sphingosine-1-phosphate (S1P) and targets S1P receptors 1, 3, 4, and 5. Recent reports indicate an association between long-term exposure to FTY720 and cases of cryptococcal infection. Here, we studied the effe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2020-09, Vol.130 (9), p.4546-4560
Hauptverfasser:	Bryan, Arielle M, You, Jeehyun Karen, McQuiston, Travis, Lazzarini, Cristina, Qiu, Zhijuan, Sheridan, Brian, Nuesslein-Hildesheim, Barbara, Del Poeta, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Brain CD4 antigen CD8 antigen Cryptococcosis Encephalitis FTY720 Granuloma Granulomas Infections Lungs Lymphocytes Lymphocytes T Macrophages Meningitis Multiple sclerosis Pathogens Phagocytosis Phenotypes Reactive oxygen species Sphingosine 1-phosphate Virulence
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!