Dual effects of S-adenosyl-methyonine on PC12 cells exposed to the dopaminergic neurotoxin MPP

Abstract Objectives To investigate S-adenosyl-methyonine (SAM) effects on PC12 cells viability and neuritogenesis treated with MPP+ (1-methyl-4-phenylpyridinium). Methods PC12 cell viability test (MTT assay) in DMEM medium with SAM and/or MPP+; PC12 cell neuritogenesis test in F-12K medium with nerv...

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Veröffentlicht in:Journal of pharmacy and pharmacology 2020-10, Vol.72 (10), p.1427-1435
Hauptverfasser: Cantelmo, Rebeca Araujo, dos Santos, Neife Aparecida G, dos Santos, Antonio Cardozo, Joca, Sâmia Regiane Lourenço
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Sprache:eng
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