ABCB1 and ERCC1 gene polymorphisms are associated with nephro- and hepatotoxicity to carboplatin/paclitaxel-based chemotherapy in patients with gynecologic cancers

Background Paclitaxel/carboplatin combination is the standard chemotherapeutic protocol for gynecologic cancers, but severe toxicities may compromise treatment. There is great inter-individual variability regarding the incidence and severity of toxicities, which may be due to single-nucleotide polym...

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Veröffentlicht in:	European journal of clinical pharmacology 2020-10, Vol.76 (10), p.1401-1408
Hauptverfasser:	da Costa Junior, Luiz Carlos, de Castro, Clarissa Lourenço, Freitas-Alves, Daniely Regina, Vianna-Jorge, Rosane, Santos, Paulo Caleb Júnior Lima
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects ATP Binding Cassette Transporter, Subfamily B - genetics Biomedical and Life Sciences Biomedicine Brazil Carboplatin Carboplatin - administration & dosage Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - genetics Chemotherapy Cohort Studies Diabetes mellitus DNA-Binding Proteins - genetics Electronic medical records Endonucleases - genetics ERCC1 gene ERCC1 protein Female Gene polymorphism Genital Neoplasms, Female - drug therapy Genotyping Gynecological cancer Gynecology Hepatotoxicity Humans Kidney Diseases - chemically induced Kidney Diseases - genetics Middle Aged Myalgia Nausea Paclitaxel Paclitaxel - administration & dosage Patients Pharmacogenetics Pharmacology/Toxicology Polymorphism, Single Nucleotide Prospective Studies Single-nucleotide polymorphism Terminology
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