Non-familial Multiple Trichoepithelioma: A Case Report
Trichoepithelioma is a well-differentiated benign follicular tumour. Clinically, it may either be solitary or multiple. Multiple trichoepitheliomas are often located on the face and its vicinity. Here, we present this case due to the increasing number of lesions over ten years, particularly with the...
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| Veröffentlicht in: | Meandros medical and dental journal 2020-08, Vol.21 (2), p.155-158 |
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| creator | Tunçel, Deniz Yılmaz Özgüven, Banu Sarı, Ahu Gülçin Karasoy Yeşilada, Ayşin Kabukçuoğlu, Fevziye Eken, Kamile Gülçin |
| description | Trichoepithelioma is a well-differentiated benign follicular tumour. Clinically, it
may either be solitary or multiple. Multiple trichoepitheliomas are often located
on the face and its vicinity. Here, we present this case due to the increasing
number of lesions over ten years, particularly with the lesions blocking the
external auditory canal. This case is presented with clinical, histopathological and
immunohistochemical features, with differential diagnoses. The patient was a
70-year-old female with localised papules on the external auditory canal, ear lobule,
tragus, neck and lower lip. The microscopic examination of the excisional biopsy
from the external auditory canal revealed a tumoural formation surrounded with
stromal fibrosis and mononuclear infiltration, which is composed of basaloid cells
showing peripheral palisading and keratinocytes with infundibular keratinisation.
Upon immunohistochemical studies, the surrounding stroma of the tumour showed
diffuse cytoplasmic positivity for CD34, and focal cytoplasmic positivity for BerEP4.
There was no significant family history in this case. This pathology must be kept in
mind in the differential diagnosis of tumours of the epidermis and skin appendages
which occur on the face and its vicinity. |
| doi_str_mv | 10.4274/meandros.galenos.2015.1862 |
| format | Article |
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may either be solitary or multiple. Multiple trichoepitheliomas are often located
on the face and its vicinity. Here, we present this case due to the increasing
number of lesions over ten years, particularly with the lesions blocking the
external auditory canal. This case is presented with clinical, histopathological and
immunohistochemical features, with differential diagnoses. The patient was a
70-year-old female with localised papules on the external auditory canal, ear lobule,
tragus, neck and lower lip. The microscopic examination of the excisional biopsy
from the external auditory canal revealed a tumoural formation surrounded with
stromal fibrosis and mononuclear infiltration, which is composed of basaloid cells
showing peripheral palisading and keratinocytes with infundibular keratinisation.
Upon immunohistochemical studies, the surrounding stroma of the tumour showed
diffuse cytoplasmic positivity for CD34, and focal cytoplasmic positivity for BerEP4.
There was no significant family history in this case. This pathology must be kept in
mind in the differential diagnosis of tumours of the epidermis and skin appendages
which occur on the face and its vicinity.</description><identifier>ISSN: 2149-9063</identifier><identifier>EISSN: 2149-9063</identifier><identifier>DOI: 10.4274/meandros.galenos.2015.1862</identifier><language>eng</language><publisher>Aydın: Adnan Menderes Üniversitesi</publisher><subject>Biopsy ; Case reports ; CD34 antigen ; Conflicts of interest ; Cysts ; Dermatology ; Differential diagnosis ; Ear canal ; Epidermis ; Fibrosis ; Hearing ; Keratin ; Keratinocytes ; Metastases ; Stroma ; Tıp ; Trichoepithelioma ; Tumors</subject><ispartof>Meandros medical and dental journal, 2020-08, Vol.21 (2), p.155-158</ispartof><rights>2020. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-9126-1895 ; 0000-0002-3540-4772 ; 0000-0001-6025-9733 ; 0000-0003-0908-1719 ; 0000-0002-7705-7510 ; 0000-0002-6071-2697</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><contributor>Turan,Yasemin</contributor><creatorcontrib>Tunçel, Deniz</creatorcontrib><creatorcontrib>Yılmaz Özgüven, Banu</creatorcontrib><creatorcontrib>Sarı, Ahu Gülçin</creatorcontrib><creatorcontrib>Karasoy Yeşilada, Ayşin</creatorcontrib><creatorcontrib>Kabukçuoğlu, Fevziye</creatorcontrib><creatorcontrib>Eken, Kamile Gülçin</creatorcontrib><title>Non-familial Multiple Trichoepithelioma: A Case Report</title><title>Meandros medical and dental journal</title><description>Trichoepithelioma is a well-differentiated benign follicular tumour. Clinically, it
may either be solitary or multiple. Multiple trichoepitheliomas are often located
on the face and its vicinity. Here, we present this case due to the increasing
number of lesions over ten years, particularly with the lesions blocking the
external auditory canal. This case is presented with clinical, histopathological and
immunohistochemical features, with differential diagnoses. The patient was a
70-year-old female with localised papules on the external auditory canal, ear lobule,
tragus, neck and lower lip. The microscopic examination of the excisional biopsy
from the external auditory canal revealed a tumoural formation surrounded with
stromal fibrosis and mononuclear infiltration, which is composed of basaloid cells
showing peripheral palisading and keratinocytes with infundibular keratinisation.
Upon immunohistochemical studies, the surrounding stroma of the tumour showed
diffuse cytoplasmic positivity for CD34, and focal cytoplasmic positivity for BerEP4.
There was no significant family history in this case. This pathology must be kept in
mind in the differential diagnosis of tumours of the epidermis and skin appendages
which occur on the face and its vicinity.</description><subject>Biopsy</subject><subject>Case reports</subject><subject>CD34 antigen</subject><subject>Conflicts of interest</subject><subject>Cysts</subject><subject>Dermatology</subject><subject>Differential diagnosis</subject><subject>Ear canal</subject><subject>Epidermis</subject><subject>Fibrosis</subject><subject>Hearing</subject><subject>Keratin</subject><subject>Keratinocytes</subject><subject>Metastases</subject><subject>Stroma</subject><subject>Tıp</subject><subject>Trichoepithelioma</subject><subject>Tumors</subject><issn>2149-9063</issn><issn>2149-9063</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpN0EFLwzAUwPEgCg7ddyh68dKZpGnS7Dbm1MFUkHkOr-mby0ibmnYHv70dm-jpvcOf9-BHyA2jE8GVuK8RmiqGbvIJHpthcsryCSskPyMjzoRONZXZ-b_9koy7bkcpZUrmOpMjIl9Dk26gdt6BT172vnetx2Qdnd0GbF2_Re9CDdNklsyhw-Qd2xD7a3KxAd_h-DSvyMfjYj1_TldvT8v5bJVaplWfyhJLsFqWWlYouVa5KASDEiuhLaiSqgIqK5QEZiGjUiNgibmUDK0oQGRX5PZ4t43ha49db3ZhH5vhpeFCUE05LfRQ3R0rVyH40HjX4F-4fFjMVoYxxQo-pNNjage4LuLGtNHVEL8No-agan5VzUnVHFTNQTX7Aeyxb38</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Tunçel, Deniz</creator><creator>Yılmaz Özgüven, Banu</creator><creator>Sarı, Ahu Gülçin</creator><creator>Karasoy Yeşilada, Ayşin</creator><creator>Kabukçuoğlu, Fevziye</creator><creator>Eken, Kamile Gülçin</creator><general>Adnan Menderes Üniversitesi</general><general>Galenos Publishing House</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IEBAR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0001-9126-1895</orcidid><orcidid>https://orcid.org/0000-0002-3540-4772</orcidid><orcidid>https://orcid.org/0000-0001-6025-9733</orcidid><orcidid>https://orcid.org/0000-0003-0908-1719</orcidid><orcidid>https://orcid.org/0000-0002-7705-7510</orcidid><orcidid>https://orcid.org/0000-0002-6071-2697</orcidid></search><sort><creationdate>20200801</creationdate><title>Non-familial Multiple Trichoepithelioma: A Case Report</title><author>Tunçel, Deniz ; 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Clinically, it
may either be solitary or multiple. Multiple trichoepitheliomas are often located
on the face and its vicinity. Here, we present this case due to the increasing
number of lesions over ten years, particularly with the lesions blocking the
external auditory canal. This case is presented with clinical, histopathological and
immunohistochemical features, with differential diagnoses. The patient was a
70-year-old female with localised papules on the external auditory canal, ear lobule,
tragus, neck and lower lip. The microscopic examination of the excisional biopsy
from the external auditory canal revealed a tumoural formation surrounded with
stromal fibrosis and mononuclear infiltration, which is composed of basaloid cells
showing peripheral palisading and keratinocytes with infundibular keratinisation.
Upon immunohistochemical studies, the surrounding stroma of the tumour showed
diffuse cytoplasmic positivity for CD34, and focal cytoplasmic positivity for BerEP4.
There was no significant family history in this case. This pathology must be kept in
mind in the differential diagnosis of tumours of the epidermis and skin appendages
which occur on the face and its vicinity.</abstract><cop>Aydın</cop><pub>Adnan Menderes Üniversitesi</pub><doi>10.4274/meandros.galenos.2015.1862</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-9126-1895</orcidid><orcidid>https://orcid.org/0000-0002-3540-4772</orcidid><orcidid>https://orcid.org/0000-0001-6025-9733</orcidid><orcidid>https://orcid.org/0000-0003-0908-1719</orcidid><orcidid>https://orcid.org/0000-0002-7705-7510</orcidid><orcidid>https://orcid.org/0000-0002-6071-2697</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Alma/SFX Local Collection |
| subjects | Biopsy Case reports CD34 antigen Conflicts of interest Cysts Dermatology Differential diagnosis Ear canal Epidermis Fibrosis Hearing Keratin Keratinocytes Metastases Stroma Tıp Trichoepithelioma Tumors |
| title | Non-familial Multiple Trichoepithelioma: A Case Report |
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