Seasonal characteristic composition of inorganic elements and polycyclic aromatic hydrocarbons in atmospheric fine particulate matter and bronchoalveolar lavage fluid of COPD patients in Northeast China
To explore the composition characteristics of atmospheric fine particulate matter (PM2.5) and bronchoalveolar lavage fluid (BALF), and their impact on the development of chronic obstructive pulmonary disease (COPD). The atmospheric PM2.5 samples and BALF samples from COPD patients were collected fro...
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| creator | Che, Chunli Li, Jialin Dong, Fushi Zhang, Chunling Liu, Lu Sun, Xiazhong Ma, Lixin Qi, Hong Wang, Kun |
| description | To explore the composition characteristics of atmospheric fine particulate matter (PM2.5) and bronchoalveolar lavage fluid (BALF), and their impact on the development of chronic obstructive pulmonary disease (COPD).
The atmospheric PM2.5 samples and BALF samples from COPD patients were collected from June 2, 2017 to October 30, 2018, and allocated into a high-risk of PM2.5 inhalation group and a low-risk PM2.5 inhalation group according to the heating season in Harbin. Inorganic elements were detected by ICP-MS, and polycyclic aromatic hydrocarbons (PAHs) were detected by GC/MS.
Twenty-six inorganic elements were found in 54 BALF specimens. There was a high correspondence in inorganic elements between BALF and atmospheric PM2.5. Trace elements Cr, Mn, V, and Co, and toxic trace elements Al, Pb, Cd, As, and Ag were above the upper limit of normal blood. There were significant higher K, Ti, Fe, Co, Cu, Se, Rb, Ag, and Sb in BALF of the high-risk PM2.5 inhalation group (p |
| doi_str_mv | 10.1016/j.rmed.2020.106082 |
| format | Article |
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The atmospheric PM2.5 samples and BALF samples from COPD patients were collected from June 2, 2017 to October 30, 2018, and allocated into a high-risk of PM2.5 inhalation group and a low-risk PM2.5 inhalation group according to the heating season in Harbin. Inorganic elements were detected by ICP-MS, and polycyclic aromatic hydrocarbons (PAHs) were detected by GC/MS.
Twenty-six inorganic elements were found in 54 BALF specimens. There was a high correspondence in inorganic elements between BALF and atmospheric PM2.5. Trace elements Cr, Mn, V, and Co, and toxic trace elements Al, Pb, Cd, As, and Ag were above the upper limit of normal blood. There were significant higher K, Ti, Fe, Co, Cu, Se, Rb, Ag, and Sb in BALF of the high-risk PM2.5 inhalation group (p < 0.05). Sixteen PAHs were detected in 32 BALF samples. The main components of BALF and atmospheric PM2.5 were the high molecular weight PAHs, and the species and concentration of PAHs in BALF and atmospheric PM2.5 are highly consistent.
The types and concentrations of inorganic elements and PAHs in BALF of COPD patients are highly consistent with those of atmospheric PM2.5. The sustained high concentrations of Benzo(a)anthracene, Chrysene, Benzo(b)Fluoranthene, Benzo(k)Fluoranthene, Indeno(123-c,d)Pyrene, and Benzo(a)Pyrene in BALF of COPD patients may have long-term adverse effects on COPD patients.
•Components of atmospheric PM2.5 can be traced in the lung of COPD patients.•Seasonal fluctuation of atmospheric PM2.5 is reflected in the lung of COPD patients.•Sustained high level of PAHs in lung may cause or exacerbate COPD.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2020.106082</identifier><identifier>PMID: 32658839</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Air pollution ; Air Pollution - adverse effects ; Air Pollution - analysis ; Aluminum ; Alveoli ; Anthracene ; BALF ; Benzo(a)pyrene ; Bronchoalveolar Lavage Fluid - chemistry ; Bronchus ; Cadmium ; China ; Chronic obstructive pulmonary disease ; Chrysene ; Cobalt ; Composition ; COPD ; Copper ; Elements ; Environmental Monitoring ; Female ; Fine particulate matter ; Fluoranthene ; Fluorenes - adverse effects ; Fluorenes - analysis ; Hospitals ; Human body ; Humans ; Inhalation ; Inorganic Chemicals - adverse effects ; Inorganic Chemicals - analysis ; Lavage ; Lung diseases ; Male ; Manganese ; Middle Aged ; Molecular weight ; Obstructive lung disease ; Particulate matter ; Particulate Matter - adverse effects ; Particulate Matter - analysis ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - adverse effects ; Polycyclic Aromatic Hydrocarbons - analysis ; Pulmonary Disease, Chronic Obstructive - etiology ; Pulmonary Disease, Chronic Obstructive - metabolism ; Pyrene ; Pyrenes - adverse effects ; Pyrenes - analysis ; Respiration ; Risk allocation ; Seasons ; Silver ; Statistical analysis ; Trace elements</subject><ispartof>Respiratory medicine, 2020-09, Vol.171, p.106082, Article 106082</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><rights>2020. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-cb1887c68eddccbb33a1ce6d10b617b5597e5c6bc003cf862aa24f009b3f9ce73</citedby><cites>FETCH-LOGICAL-c494t-cb1887c68eddccbb33a1ce6d10b617b5597e5c6bc003cf862aa24f009b3f9ce73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0954611120302225$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32658839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Che, Chunli</creatorcontrib><creatorcontrib>Li, Jialin</creatorcontrib><creatorcontrib>Dong, Fushi</creatorcontrib><creatorcontrib>Zhang, Chunling</creatorcontrib><creatorcontrib>Liu, Lu</creatorcontrib><creatorcontrib>Sun, Xiazhong</creatorcontrib><creatorcontrib>Ma, Lixin</creatorcontrib><creatorcontrib>Qi, Hong</creatorcontrib><creatorcontrib>Wang, Kun</creatorcontrib><title>Seasonal characteristic composition of inorganic elements and polycyclic aromatic hydrocarbons in atmospheric fine particulate matter and bronchoalveolar lavage fluid of COPD patients in Northeast China</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>To explore the composition characteristics of atmospheric fine particulate matter (PM2.5) and bronchoalveolar lavage fluid (BALF), and their impact on the development of chronic obstructive pulmonary disease (COPD).
The atmospheric PM2.5 samples and BALF samples from COPD patients were collected from June 2, 2017 to October 30, 2018, and allocated into a high-risk of PM2.5 inhalation group and a low-risk PM2.5 inhalation group according to the heating season in Harbin. Inorganic elements were detected by ICP-MS, and polycyclic aromatic hydrocarbons (PAHs) were detected by GC/MS.
Twenty-six inorganic elements were found in 54 BALF specimens. There was a high correspondence in inorganic elements between BALF and atmospheric PM2.5. Trace elements Cr, Mn, V, and Co, and toxic trace elements Al, Pb, Cd, As, and Ag were above the upper limit of normal blood. There were significant higher K, Ti, Fe, Co, Cu, Se, Rb, Ag, and Sb in BALF of the high-risk PM2.5 inhalation group (p < 0.05). Sixteen PAHs were detected in 32 BALF samples. The main components of BALF and atmospheric PM2.5 were the high molecular weight PAHs, and the species and concentration of PAHs in BALF and atmospheric PM2.5 are highly consistent.
The types and concentrations of inorganic elements and PAHs in BALF of COPD patients are highly consistent with those of atmospheric PM2.5. The sustained high concentrations of Benzo(a)anthracene, Chrysene, Benzo(b)Fluoranthene, Benzo(k)Fluoranthene, Indeno(123-c,d)Pyrene, and Benzo(a)Pyrene in BALF of COPD patients may have long-term adverse effects on COPD patients.
•Components of atmospheric PM2.5 can be traced in the lung of COPD patients.•Seasonal fluctuation of atmospheric PM2.5 is reflected in the lung of COPD patients.•Sustained high level of PAHs in lung may cause or exacerbate COPD.</description><subject>Aged</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Air Pollution - analysis</subject><subject>Aluminum</subject><subject>Alveoli</subject><subject>Anthracene</subject><subject>BALF</subject><subject>Benzo(a)pyrene</subject><subject>Bronchoalveolar Lavage Fluid - chemistry</subject><subject>Bronchus</subject><subject>Cadmium</subject><subject>China</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Chrysene</subject><subject>Cobalt</subject><subject>Composition</subject><subject>COPD</subject><subject>Copper</subject><subject>Elements</subject><subject>Environmental Monitoring</subject><subject>Female</subject><subject>Fine particulate matter</subject><subject>Fluoranthene</subject><subject>Fluorenes - adverse effects</subject><subject>Fluorenes - analysis</subject><subject>Hospitals</subject><subject>Human body</subject><subject>Humans</subject><subject>Inhalation</subject><subject>Inorganic Chemicals - adverse effects</subject><subject>Inorganic Chemicals - analysis</subject><subject>Lavage</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Manganese</subject><subject>Middle Aged</subject><subject>Molecular weight</subject><subject>Obstructive lung disease</subject><subject>Particulate matter</subject><subject>Particulate Matter - adverse effects</subject><subject>Particulate Matter - analysis</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Polycyclic Aromatic Hydrocarbons - adverse effects</subject><subject>Polycyclic Aromatic Hydrocarbons - analysis</subject><subject>Pulmonary Disease, Chronic Obstructive - etiology</subject><subject>Pulmonary Disease, Chronic Obstructive - metabolism</subject><subject>Pyrene</subject><subject>Pyrenes - adverse effects</subject><subject>Pyrenes - analysis</subject><subject>Respiration</subject><subject>Risk allocation</subject><subject>Seasons</subject><subject>Silver</subject><subject>Statistical analysis</subject><subject>Trace elements</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcuO1DAQtBCIHRZ-gAOyxHkGOw9PInFBw1NasUjA2Wp3OhuPnDjYzkjzi3wVzs7ulVNL3VXV3VWMvZZiJ4VU7467MFK3K0SxNpRoiidsI-uy2JZCVU_ZRrR1tVVSyiv2IsajEKKtKvGcXZWFqpumbDfs70-C6CdwHAcIgImCjckiRz_OPtpk_cR9z-3kwx1MeUCORppS5DB1fPbujGd0uQ_Bj7Ayh3MXPEIwfoqZxyGNPs5DFkbe24n4DCHjFgeJeKbklfdaJvgJBw_uRN5B4A5OcEe8d4vt1hMOtz8-Zm6y99uz8Hcf0pDPT_ww2Alesmc9uEivHuo1-_3506_D1-3N7Zdvhw83W6zaKm3RyKbZo2qo6xCNKUuQSKqTwii5N3Xd7qlGZVCIEvtGFQBF1WfrTNm3SPvymr296M7B_1koJn30S8gWRl1ke5umrYTMqOKCwuBjDNTrOdgRwllLodf49FGv8ek1Pn2JL5PePEgvZp09Uh7zyoD3FwDlB0-Wgo6Y_UDqbCBMuvP2f_r_ACyIsi4</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Che, Chunli</creator><creator>Li, Jialin</creator><creator>Dong, Fushi</creator><creator>Zhang, Chunling</creator><creator>Liu, Lu</creator><creator>Sun, Xiazhong</creator><creator>Ma, Lixin</creator><creator>Qi, Hong</creator><creator>Wang, Kun</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>202009</creationdate><title>Seasonal characteristic composition of inorganic elements and polycyclic aromatic hydrocarbons in atmospheric fine particulate matter and bronchoalveolar lavage fluid of COPD patients in Northeast China</title><author>Che, Chunli ; Li, Jialin ; Dong, Fushi ; Zhang, Chunling ; Liu, Lu ; Sun, Xiazhong ; Ma, Lixin ; Qi, Hong ; Wang, Kun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-cb1887c68eddccbb33a1ce6d10b617b5597e5c6bc003cf862aa24f009b3f9ce73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Air Pollution - analysis</topic><topic>Aluminum</topic><topic>Alveoli</topic><topic>Anthracene</topic><topic>BALF</topic><topic>Benzo(a)pyrene</topic><topic>Bronchoalveolar Lavage Fluid - chemistry</topic><topic>Bronchus</topic><topic>Cadmium</topic><topic>China</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Chrysene</topic><topic>Cobalt</topic><topic>Composition</topic><topic>COPD</topic><topic>Copper</topic><topic>Elements</topic><topic>Environmental Monitoring</topic><topic>Female</topic><topic>Fine particulate matter</topic><topic>Fluoranthene</topic><topic>Fluorenes - adverse effects</topic><topic>Fluorenes - analysis</topic><topic>Hospitals</topic><topic>Human body</topic><topic>Humans</topic><topic>Inhalation</topic><topic>Inorganic Chemicals - adverse effects</topic><topic>Inorganic Chemicals - analysis</topic><topic>Lavage</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Manganese</topic><topic>Middle Aged</topic><topic>Molecular weight</topic><topic>Obstructive lung disease</topic><topic>Particulate matter</topic><topic>Particulate Matter - adverse effects</topic><topic>Particulate Matter - analysis</topic><topic>Polycyclic aromatic hydrocarbons</topic><topic>Polycyclic Aromatic Hydrocarbons - adverse effects</topic><topic>Polycyclic Aromatic Hydrocarbons - analysis</topic><topic>Pulmonary Disease, Chronic Obstructive - etiology</topic><topic>Pulmonary Disease, Chronic Obstructive - metabolism</topic><topic>Pyrene</topic><topic>Pyrenes - adverse effects</topic><topic>Pyrenes - analysis</topic><topic>Respiration</topic><topic>Risk allocation</topic><topic>Seasons</topic><topic>Silver</topic><topic>Statistical analysis</topic><topic>Trace elements</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Che, Chunli</creatorcontrib><creatorcontrib>Li, Jialin</creatorcontrib><creatorcontrib>Dong, Fushi</creatorcontrib><creatorcontrib>Zhang, Chunling</creatorcontrib><creatorcontrib>Liu, Lu</creatorcontrib><creatorcontrib>Sun, Xiazhong</creatorcontrib><creatorcontrib>Ma, Lixin</creatorcontrib><creatorcontrib>Qi, Hong</creatorcontrib><creatorcontrib>Wang, Kun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Che, Chunli</au><au>Li, Jialin</au><au>Dong, Fushi</au><au>Zhang, Chunling</au><au>Liu, Lu</au><au>Sun, Xiazhong</au><au>Ma, Lixin</au><au>Qi, Hong</au><au>Wang, Kun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seasonal characteristic composition of inorganic elements and polycyclic aromatic hydrocarbons in atmospheric fine particulate matter and bronchoalveolar lavage fluid of COPD patients in Northeast China</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2020-09</date><risdate>2020</risdate><volume>171</volume><spage>106082</spage><pages>106082-</pages><artnum>106082</artnum><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>To explore the composition characteristics of atmospheric fine particulate matter (PM2.5) and bronchoalveolar lavage fluid (BALF), and their impact on the development of chronic obstructive pulmonary disease (COPD).
The atmospheric PM2.5 samples and BALF samples from COPD patients were collected from June 2, 2017 to October 30, 2018, and allocated into a high-risk of PM2.5 inhalation group and a low-risk PM2.5 inhalation group according to the heating season in Harbin. Inorganic elements were detected by ICP-MS, and polycyclic aromatic hydrocarbons (PAHs) were detected by GC/MS.
Twenty-six inorganic elements were found in 54 BALF specimens. There was a high correspondence in inorganic elements between BALF and atmospheric PM2.5. Trace elements Cr, Mn, V, and Co, and toxic trace elements Al, Pb, Cd, As, and Ag were above the upper limit of normal blood. There were significant higher K, Ti, Fe, Co, Cu, Se, Rb, Ag, and Sb in BALF of the high-risk PM2.5 inhalation group (p < 0.05). Sixteen PAHs were detected in 32 BALF samples. The main components of BALF and atmospheric PM2.5 were the high molecular weight PAHs, and the species and concentration of PAHs in BALF and atmospheric PM2.5 are highly consistent.
The types and concentrations of inorganic elements and PAHs in BALF of COPD patients are highly consistent with those of atmospheric PM2.5. The sustained high concentrations of Benzo(a)anthracene, Chrysene, Benzo(b)Fluoranthene, Benzo(k)Fluoranthene, Indeno(123-c,d)Pyrene, and Benzo(a)Pyrene in BALF of COPD patients may have long-term adverse effects on COPD patients.
•Components of atmospheric PM2.5 can be traced in the lung of COPD patients.•Seasonal fluctuation of atmospheric PM2.5 is reflected in the lung of COPD patients.•Sustained high level of PAHs in lung may cause or exacerbate COPD.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32658839</pmid><doi>10.1016/j.rmed.2020.106082</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Air pollution Air Pollution - adverse effects Air Pollution - analysis Aluminum Alveoli Anthracene BALF Benzo(a)pyrene Bronchoalveolar Lavage Fluid - chemistry Bronchus Cadmium China Chronic obstructive pulmonary disease Chrysene Cobalt Composition COPD Copper Elements Environmental Monitoring Female Fine particulate matter Fluoranthene Fluorenes - adverse effects Fluorenes - analysis Hospitals Human body Humans Inhalation Inorganic Chemicals - adverse effects Inorganic Chemicals - analysis Lavage Lung diseases Male Manganese Middle Aged Molecular weight Obstructive lung disease Particulate matter Particulate Matter - adverse effects Particulate Matter - analysis Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - adverse effects Polycyclic Aromatic Hydrocarbons - analysis Pulmonary Disease, Chronic Obstructive - etiology Pulmonary Disease, Chronic Obstructive - metabolism Pyrene Pyrenes - adverse effects Pyrenes - analysis Respiration Risk allocation Seasons Silver Statistical analysis Trace elements |
| title | Seasonal characteristic composition of inorganic elements and polycyclic aromatic hydrocarbons in atmospheric fine particulate matter and bronchoalveolar lavage fluid of COPD patients in Northeast China |
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