Novel biomimetic dual-mode nanodroplets as ultrasound contrast agents with potential ability of precise detection and photothermal ablation of tumors
Purpose Molecule-targeted ultrasound imaging has attracted extensive attention for precise diagnosis and targeted therapy of tumors. The aim of this research is to prepare novel biomimetic dual-mode nanoscale ultrasound contrast agents (UCAs), which can not only evade the immune clearance of reticul...
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| Veröffentlicht in: | Cancer chemotherapy and pharmacology 2020-09, Vol.86 (3), p.405-418 |
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| creator | Liang, Yuan Yang, Hengli Li, Qiaoying Zhao, Ping Li, Han Zhang, Yuxin Cai, Wenbin Ma, Xiaoju Duan, Yunyou |
| description | Purpose
Molecule-targeted ultrasound imaging has attracted extensive attention for precise diagnosis and targeted therapy of tumors. The aim of this research is to prepare novel biomimetic dual-mode nanoscale ultrasound contrast agents (UCAs), which can not only evade the immune clearance of reticuloendothelial system, but also have the potential ability of precise detection and photothermal ablation of tumors.
Methods
In this study, for the first time, the novel biomimetic UCAs were prepared by encapsulating liquid perfluorohexanes with red blood cell membranes carrying IR-780 iodide and named IR780-RBCM@NDs. The characteristics of that were verified through the particle size analyzer, scanning electron microscopy, transmission electron microscopy and laser scanning confocal microscopy. The stability of IR780-RBCM@NDs at 37 °C was explored. The abilities of immune escape, dual-mode imaging and photothermal effect for IR780-RBCM@NDs were verified via in vitro experiments.
Results
The novel prepared nanodroplets have good characteristics such as mean diameter, zeta potential, and relatively stability. Importantly, the integrin-associated protein expressed on the surface of RBCMs was detected on IR780-RBCM@NDs. Then, compared with control groups, IR780-RBCM@NDs performed excellent immune escape function away from macrophages in vitro. Furthermore, the IR-780 iodide was observed on the new nanodroplets and that was able to perform the dual-mode imaging with near-infrared fluorescence imaging and contrast-enhanced ultrasound imaging after the phase change. Finally, the effective photothermal ablation ability of IR780-RBCM@NDs was verified in tumor cells.
Conclusion
The newly prepared biomimetic IR780-RBCM@NDs provided novel ideas for evading immune clearance, performing precise diagnosis and photothermal ablation of tumor cells. |
| doi_str_mv | 10.1007/s00280-020-04124-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2440760140</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2440760140</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-5a9eff0b069bdd21235b4190bcfc5083426c1b3409e4d958493e44c39bd63bc43</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS1ERYfCC7BAllgHru2byWSJKkorVbApa8s_Nx1XSRxsB9oH4X1xZwrsWFj21fnOuZIPY28EvBcA3YcMIHfQgKwHhcTm_hnbCFSygR2q52wDCrFpO8BT9jLnO4CKKfWCnSrZ9Z1sxYb9-hJ_0MhtiFOYqATH_WrGZoqe-Gzm6FNcRiqZm8zXsSST4zp77uL8-C7c3NJc1Z-h7PkSSx2CGbmxYQzlgceBL4lcyMQ9FXIlxJmb6l_2scSypzQd6NEclIqXdYopv2IngxkzvX66z9i3i08355fN9dfPV-cfrxunurY0relpGMDCtrfeSyFVa1H0YN3gWtgplFsnrELoCX3f7rBXhOhUpbfKOlRn7N0xd0nx-0q56Lu4prmu1BIRui0IhErJI-VSzDnRoJcUJpMetAD92IQ-NqFrE_rQhL6vprdP0audyP-1_Pn6CqgjkKs031L6t_s_sb8BbomYFg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2440760140</pqid></control><display><type>article</type><title>Novel biomimetic dual-mode nanodroplets as ultrasound contrast agents with potential ability of precise detection and photothermal ablation of tumors</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Liang, Yuan ; Yang, Hengli ; Li, Qiaoying ; Zhao, Ping ; Li, Han ; Zhang, Yuxin ; Cai, Wenbin ; Ma, Xiaoju ; Duan, Yunyou</creator><creatorcontrib>Liang, Yuan ; Yang, Hengli ; Li, Qiaoying ; Zhao, Ping ; Li, Han ; Zhang, Yuxin ; Cai, Wenbin ; Ma, Xiaoju ; Duan, Yunyou</creatorcontrib><description>Purpose
Molecule-targeted ultrasound imaging has attracted extensive attention for precise diagnosis and targeted therapy of tumors. The aim of this research is to prepare novel biomimetic dual-mode nanoscale ultrasound contrast agents (UCAs), which can not only evade the immune clearance of reticuloendothelial system, but also have the potential ability of precise detection and photothermal ablation of tumors.
Methods
In this study, for the first time, the novel biomimetic UCAs were prepared by encapsulating liquid perfluorohexanes with red blood cell membranes carrying IR-780 iodide and named IR780-RBCM@NDs. The characteristics of that were verified through the particle size analyzer, scanning electron microscopy, transmission electron microscopy and laser scanning confocal microscopy. The stability of IR780-RBCM@NDs at 37 °C was explored. The abilities of immune escape, dual-mode imaging and photothermal effect for IR780-RBCM@NDs were verified via in vitro experiments.
Results
The novel prepared nanodroplets have good characteristics such as mean diameter, zeta potential, and relatively stability. Importantly, the integrin-associated protein expressed on the surface of RBCMs was detected on IR780-RBCM@NDs. Then, compared with control groups, IR780-RBCM@NDs performed excellent immune escape function away from macrophages in vitro. Furthermore, the IR-780 iodide was observed on the new nanodroplets and that was able to perform the dual-mode imaging with near-infrared fluorescence imaging and contrast-enhanced ultrasound imaging after the phase change. Finally, the effective photothermal ablation ability of IR780-RBCM@NDs was verified in tumor cells.
Conclusion
The newly prepared biomimetic IR780-RBCM@NDs provided novel ideas for evading immune clearance, performing precise diagnosis and photothermal ablation of tumor cells.</description><identifier>ISSN: 0344-5704</identifier><identifier>EISSN: 1432-0843</identifier><identifier>DOI: 10.1007/s00280-020-04124-x</identifier><identifier>PMID: 32797251</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Ablation ; Animals ; Biomimetics ; Cancer Research ; Cell membranes ; Confocal microscopy ; Contrast agents ; Contrast Media - chemistry ; Diagnosis ; Erythrocytes ; Fluorescence ; Humans ; Hyperthermia, Induced ; Immune clearance ; Indoles - chemistry ; Infrared imaging ; Iodides ; Macrophages ; Macrophages - cytology ; Macrophages - metabolism ; Medicine ; Medicine & Public Health ; Mice ; Microscopy ; Multimodal Imaging ; Nanoparticles - administration & dosage ; Nanoparticles - chemistry ; Neoplasms - diagnosis ; Neoplasms - diagnostic imaging ; Neoplasms - metabolism ; Neoplasms - therapy ; Oncology ; Original Article ; Pharmacology/Toxicology ; Phototherapy ; Reticuloendothelial system ; Scanning electron microscopy ; Transmission electron microscopy ; Tumor cells ; Tumors ; Ultrasonic imaging ; Ultrasonography - methods ; Ultrasound ; Zeta potential</subject><ispartof>Cancer chemotherapy and pharmacology, 2020-09, Vol.86 (3), p.405-418</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-5a9eff0b069bdd21235b4190bcfc5083426c1b3409e4d958493e44c39bd63bc43</citedby><cites>FETCH-LOGICAL-c375t-5a9eff0b069bdd21235b4190bcfc5083426c1b3409e4d958493e44c39bd63bc43</cites><orcidid>0000-0002-5634-7164</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00280-020-04124-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00280-020-04124-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32797251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Yuan</creatorcontrib><creatorcontrib>Yang, Hengli</creatorcontrib><creatorcontrib>Li, Qiaoying</creatorcontrib><creatorcontrib>Zhao, Ping</creatorcontrib><creatorcontrib>Li, Han</creatorcontrib><creatorcontrib>Zhang, Yuxin</creatorcontrib><creatorcontrib>Cai, Wenbin</creatorcontrib><creatorcontrib>Ma, Xiaoju</creatorcontrib><creatorcontrib>Duan, Yunyou</creatorcontrib><title>Novel biomimetic dual-mode nanodroplets as ultrasound contrast agents with potential ability of precise detection and photothermal ablation of tumors</title><title>Cancer chemotherapy and pharmacology</title><addtitle>Cancer Chemother Pharmacol</addtitle><addtitle>Cancer Chemother Pharmacol</addtitle><description>Purpose
Molecule-targeted ultrasound imaging has attracted extensive attention for precise diagnosis and targeted therapy of tumors. The aim of this research is to prepare novel biomimetic dual-mode nanoscale ultrasound contrast agents (UCAs), which can not only evade the immune clearance of reticuloendothelial system, but also have the potential ability of precise detection and photothermal ablation of tumors.
Methods
In this study, for the first time, the novel biomimetic UCAs were prepared by encapsulating liquid perfluorohexanes with red blood cell membranes carrying IR-780 iodide and named IR780-RBCM@NDs. The characteristics of that were verified through the particle size analyzer, scanning electron microscopy, transmission electron microscopy and laser scanning confocal microscopy. The stability of IR780-RBCM@NDs at 37 °C was explored. The abilities of immune escape, dual-mode imaging and photothermal effect for IR780-RBCM@NDs were verified via in vitro experiments.
Results
The novel prepared nanodroplets have good characteristics such as mean diameter, zeta potential, and relatively stability. Importantly, the integrin-associated protein expressed on the surface of RBCMs was detected on IR780-RBCM@NDs. Then, compared with control groups, IR780-RBCM@NDs performed excellent immune escape function away from macrophages in vitro. Furthermore, the IR-780 iodide was observed on the new nanodroplets and that was able to perform the dual-mode imaging with near-infrared fluorescence imaging and contrast-enhanced ultrasound imaging after the phase change. Finally, the effective photothermal ablation ability of IR780-RBCM@NDs was verified in tumor cells.
Conclusion
The newly prepared biomimetic IR780-RBCM@NDs provided novel ideas for evading immune clearance, performing precise diagnosis and photothermal ablation of tumor cells.</description><subject>Ablation</subject><subject>Animals</subject><subject>Biomimetics</subject><subject>Cancer Research</subject><subject>Cell membranes</subject><subject>Confocal microscopy</subject><subject>Contrast agents</subject><subject>Contrast Media - chemistry</subject><subject>Diagnosis</subject><subject>Erythrocytes</subject><subject>Fluorescence</subject><subject>Humans</subject><subject>Hyperthermia, Induced</subject><subject>Immune clearance</subject><subject>Indoles - chemistry</subject><subject>Infrared imaging</subject><subject>Iodides</subject><subject>Macrophages</subject><subject>Macrophages - cytology</subject><subject>Macrophages - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Microscopy</subject><subject>Multimodal Imaging</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - therapy</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pharmacology/Toxicology</subject><subject>Phototherapy</subject><subject>Reticuloendothelial system</subject><subject>Scanning electron microscopy</subject><subject>Transmission electron microscopy</subject><subject>Tumor cells</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography - methods</subject><subject>Ultrasound</subject><subject>Zeta potential</subject><issn>0344-5704</issn><issn>1432-0843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1u1DAUhS1ERYfCC7BAllgHru2byWSJKkorVbApa8s_Nx1XSRxsB9oH4X1xZwrsWFj21fnOuZIPY28EvBcA3YcMIHfQgKwHhcTm_hnbCFSygR2q52wDCrFpO8BT9jLnO4CKKfWCnSrZ9Z1sxYb9-hJ_0MhtiFOYqATH_WrGZoqe-Gzm6FNcRiqZm8zXsSST4zp77uL8-C7c3NJc1Z-h7PkSSx2CGbmxYQzlgceBL4lcyMQ9FXIlxJmb6l_2scSypzQd6NEclIqXdYopv2IngxkzvX66z9i3i08355fN9dfPV-cfrxunurY0relpGMDCtrfeSyFVa1H0YN3gWtgplFsnrELoCX3f7rBXhOhUpbfKOlRn7N0xd0nx-0q56Lu4prmu1BIRui0IhErJI-VSzDnRoJcUJpMetAD92IQ-NqFrE_rQhL6vprdP0audyP-1_Pn6CqgjkKs031L6t_s_sb8BbomYFg</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Liang, Yuan</creator><creator>Yang, Hengli</creator><creator>Li, Qiaoying</creator><creator>Zhao, Ping</creator><creator>Li, Han</creator><creator>Zhang, Yuxin</creator><creator>Cai, Wenbin</creator><creator>Ma, Xiaoju</creator><creator>Duan, Yunyou</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-5634-7164</orcidid></search><sort><creationdate>20200901</creationdate><title>Novel biomimetic dual-mode nanodroplets as ultrasound contrast agents with potential ability of precise detection and photothermal ablation of tumors</title><author>Liang, Yuan ; Yang, Hengli ; Li, Qiaoying ; Zhao, Ping ; Li, Han ; Zhang, Yuxin ; Cai, Wenbin ; Ma, Xiaoju ; Duan, Yunyou</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-5a9eff0b069bdd21235b4190bcfc5083426c1b3409e4d958493e44c39bd63bc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Ablation</topic><topic>Animals</topic><topic>Biomimetics</topic><topic>Cancer Research</topic><topic>Cell membranes</topic><topic>Confocal microscopy</topic><topic>Contrast agents</topic><topic>Contrast Media - chemistry</topic><topic>Diagnosis</topic><topic>Erythrocytes</topic><topic>Fluorescence</topic><topic>Humans</topic><topic>Hyperthermia, Induced</topic><topic>Immune clearance</topic><topic>Indoles - chemistry</topic><topic>Infrared imaging</topic><topic>Iodides</topic><topic>Macrophages</topic><topic>Macrophages - cytology</topic><topic>Macrophages - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Microscopy</topic><topic>Multimodal Imaging</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - diagnostic imaging</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - therapy</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pharmacology/Toxicology</topic><topic>Phototherapy</topic><topic>Reticuloendothelial system</topic><topic>Scanning electron microscopy</topic><topic>Transmission electron microscopy</topic><topic>Tumor cells</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography - methods</topic><topic>Ultrasound</topic><topic>Zeta potential</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Yuan</creatorcontrib><creatorcontrib>Yang, Hengli</creatorcontrib><creatorcontrib>Li, Qiaoying</creatorcontrib><creatorcontrib>Zhao, Ping</creatorcontrib><creatorcontrib>Li, Han</creatorcontrib><creatorcontrib>Zhang, Yuxin</creatorcontrib><creatorcontrib>Cai, Wenbin</creatorcontrib><creatorcontrib>Ma, Xiaoju</creatorcontrib><creatorcontrib>Duan, Yunyou</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Cancer chemotherapy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Yuan</au><au>Yang, Hengli</au><au>Li, Qiaoying</au><au>Zhao, Ping</au><au>Li, Han</au><au>Zhang, Yuxin</au><au>Cai, Wenbin</au><au>Ma, Xiaoju</au><au>Duan, Yunyou</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel biomimetic dual-mode nanodroplets as ultrasound contrast agents with potential ability of precise detection and photothermal ablation of tumors</atitle><jtitle>Cancer chemotherapy and pharmacology</jtitle><stitle>Cancer Chemother Pharmacol</stitle><addtitle>Cancer Chemother Pharmacol</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>86</volume><issue>3</issue><spage>405</spage><epage>418</epage><pages>405-418</pages><issn>0344-5704</issn><eissn>1432-0843</eissn><abstract>Purpose
Molecule-targeted ultrasound imaging has attracted extensive attention for precise diagnosis and targeted therapy of tumors. The aim of this research is to prepare novel biomimetic dual-mode nanoscale ultrasound contrast agents (UCAs), which can not only evade the immune clearance of reticuloendothelial system, but also have the potential ability of precise detection and photothermal ablation of tumors.
Methods
In this study, for the first time, the novel biomimetic UCAs were prepared by encapsulating liquid perfluorohexanes with red blood cell membranes carrying IR-780 iodide and named IR780-RBCM@NDs. The characteristics of that were verified through the particle size analyzer, scanning electron microscopy, transmission electron microscopy and laser scanning confocal microscopy. The stability of IR780-RBCM@NDs at 37 °C was explored. The abilities of immune escape, dual-mode imaging and photothermal effect for IR780-RBCM@NDs were verified via in vitro experiments.
Results
The novel prepared nanodroplets have good characteristics such as mean diameter, zeta potential, and relatively stability. Importantly, the integrin-associated protein expressed on the surface of RBCMs was detected on IR780-RBCM@NDs. Then, compared with control groups, IR780-RBCM@NDs performed excellent immune escape function away from macrophages in vitro. Furthermore, the IR-780 iodide was observed on the new nanodroplets and that was able to perform the dual-mode imaging with near-infrared fluorescence imaging and contrast-enhanced ultrasound imaging after the phase change. Finally, the effective photothermal ablation ability of IR780-RBCM@NDs was verified in tumor cells.
Conclusion
The newly prepared biomimetic IR780-RBCM@NDs provided novel ideas for evading immune clearance, performing precise diagnosis and photothermal ablation of tumor cells.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32797251</pmid><doi>10.1007/s00280-020-04124-x</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-5634-7164</orcidid></addata></record> |
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| subjects | Ablation Animals Biomimetics Cancer Research Cell membranes Confocal microscopy Contrast agents Contrast Media - chemistry Diagnosis Erythrocytes Fluorescence Humans Hyperthermia, Induced Immune clearance Indoles - chemistry Infrared imaging Iodides Macrophages Macrophages - cytology Macrophages - metabolism Medicine Medicine & Public Health Mice Microscopy Multimodal Imaging Nanoparticles - administration & dosage Nanoparticles - chemistry Neoplasms - diagnosis Neoplasms - diagnostic imaging Neoplasms - metabolism Neoplasms - therapy Oncology Original Article Pharmacology/Toxicology Phototherapy Reticuloendothelial system Scanning electron microscopy Transmission electron microscopy Tumor cells Tumors Ultrasonic imaging Ultrasonography - methods Ultrasound Zeta potential |
| title | Novel biomimetic dual-mode nanodroplets as ultrasound contrast agents with potential ability of precise detection and photothermal ablation of tumors |
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