Barbatic acid from Cladia aggregata (lichen): Cytotoxicity and in vitro schistosomicidal evaluation and ultrastructural analysis against adult worms of Schistosoma mansoni

Schistosomiasis is one of the most significant neglected tropical diseases, affecting around 260 million people worldwide, and Praziquantel is currently the only available drug for the treatment of infected persons. Thus, the search for new schistosomicidal compounds is urgent. The objective of this...

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Veröffentlicht in:	Toxicology in vitro 2020-06, Vol.65, p.104771, Article 104771
Hauptverfasser:	Silva, H.A.M.F., Aires, A.L., Soares, C.L.R., Sá, J.L.F., Martins, M.C.B., Albuquerque, M.C.P.A., Silva, T.G., Brayner, F.A., Alves, L.C., Melo, A.M.M.A., Silva, N.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Anthelmintic activity Ascomycota - chemistry Barbatic acid Blood Cell Survival - drug effects Cell viability Cells, Cultured Cytotoxicity Damage Evaluation Human performance Humans Lethality Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Lichens - chemistry Life Sciences & Biomedicine Metabolites Microscopy, Electron, Scanning Motility Peripheral blood mononuclear cells Phthalic Acids - toxicity Praziquantel Scanning electron microscopy Schistosoma mansoni Schistosoma mansoni - drug effects Schistosoma mansoni - ultrastructure Schistosoma mansoni Schistosomiasis Schistosomiasis Science & Technology Tegument Toxicity Toxicology Tropical diseases Ultrastructural analysis Worms
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