A highlight on CD4+ T-cells in the spleen in a rat model of rheumatoid arthritis and possible therapeutic effect of omega-3. Histological and Immunofluorescence study

•Rheumatoid arthritis (RA) induced noticeable structural changes in the spleen.•Progressive RA showed extensive expression of AntiCD4 Monoclonal Antibodies.•Plasma cells, dendritic cells and Anitschkow cells were identified in the spleen in RA.•Omega-3 significantly improved the structure of the spl...

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Veröffentlicht in:	International immunopharmacology 2020-04, Vol.81, p.106283, Article 106283
1. Verfasser:	El-Waseef, Dalia Alaa El-Din Aly
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antirheumatic Agents - therapeutic use Arthritis Arthritis, Experimental - immunology Arthritis, Experimental - therapy Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - therapy Blood vessels CD4 antigen CD4+ T-cells CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Disease control Disease Progression Fatty Acids, Omega-3 - therapeutic use Fluorescent Antibody Technique Freund's Adjuvant Humans Immunofluorescence Injection Lymphocytes Lymphocytes T Male Methotrexate - therapeutic use Monoclonal antibodies Omega-3 Organs Paraffin Paraffins Rats Rats, Inbred Strains Red pulp Rheumatoid arthritis Rodents Sine waves Spleen Spleen - pathology
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