Tritium-Labeled Dopamine, Serotonin, and Doxorubicine Derivatives Containing Fragments Unstable under Hydrogenation Conditions

Tritium-Labeled Dopamine, Serotonin, and Doxorubicine Derivatives Containing Fragments Unstable under Hydrogenation Conditions

Necessary precursors for obtaining tritium-labeled Z-Gly-Pro-DOPA, Z-Gly-Pro-SRT, Z-Gly-Pro-Dox, OL-Gly-Pro-DOPA,Ol-Gly-Pro-Srt were synthesized for the first time (Gly stands for glycine; Pro, proline; Ol, Oleic acid, DOPA, dopamine; Dox, Doxorubicin; Srt, Serotonin; and Z, benzyloxycarbonyl protec...

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Veröffentlicht in:Radiochemistry (New York, N.Y.) N.Y.), 2020-04, Vol.62 (4), p.539-542
Hauptverfasser: Shevchenko, V. P., Andreeva, L. A., Shevchenko, K. V., Nagaev, I. Yu, Myasoedov, N. F.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
Dopamine
Doxorubicin
Glycine
Nuclear Chemistry
Oleic acid
Proline
Serotonin
Synthesis
Tritium
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container_issue 4
container_start_page 539
container_title Radiochemistry (New York, N.Y.)
container_volume 62
creator Shevchenko, V. P.
Andreeva, L. A.
Shevchenko, K. V.
Nagaev, I. Yu
Myasoedov, N. F.
description Necessary precursors for obtaining tritium-labeled Z-Gly-Pro-DOPA, Z-Gly-Pro-SRT, Z-Gly-Pro-Dox, OL-Gly-Pro-DOPA,Ol-Gly-Pro-Srt were synthesized for the first time (Gly stands for glycine; Pro, proline; Ol, Oleic acid, DOPA, dopamine; Dox, Doxorubicin; Srt, Serotonin; and Z, benzyloxycarbonyl protection). The tritium-labeled proline and glycine were used to synthesize peptide derivatives of DOPA, Dox, and Srt with different tritium distributions.
doi_str_mv 10.1134/S1066362220040116
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subjects Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
Dopamine
Doxorubicin
Glycine
Nuclear Chemistry
Oleic acid
Proline
Serotonin
Synthesis
Tritium
title Tritium-Labeled Dopamine, Serotonin, and Doxorubicine Derivatives Containing Fragments Unstable under Hydrogenation Conditions
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