Cedrol protects against chronic constriction injury-induced neuropathic pain through inhibiting oxidative stress and inflammation

Injured somatosensory nervous system cause neuropathic pain which is quite difficult to treat using current approaches. It is therefore important to find new therapeutic options. We have analyzed cedrol effect on chronic constriction injury (CCI) induced neuropathic pain in rats. The mechanical and...

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Veröffentlicht in:	Metabolic brain disease 2020-10, Vol.35 (7), p.1119-1126
Hauptverfasser:	Sakhaee, Mohammad Hossein, Sayyadi, Seyed Amir Hossein, Sakhaee, Nader, Sadeghnia, Hamid R., Hosseinzadeh, Hossein, Nourbakhsh, Fahimeh, Forouzanfar, Fatemeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone Animals Attenuation Biochemistry Biomarkers Biomedical and Life Sciences Biomedicine Constrictions Hypersensitivity Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammatory response Injuries Injury analysis Interleukin 6 Interleukin-6 - metabolism Male Malondialdehyde Malondialdehyde - metabolism Metabolic Diseases Nervous system Neuralgia Neuralgia - metabolism Neuralgia - prevention & control Neurology Neurosciences Oncology Original Article Oxidative stress Oxidative Stress - drug effects Pain Pain Threshold - drug effects Polycyclic Sesquiterpenes - pharmacology Polycyclic Sesquiterpenes - therapeutic use Protective Agents - pharmacology Protective Agents - therapeutic use Rats Rats, Wistar Sensory Receptor Cells - drug effects Sensory Receptor Cells - metabolism Spinal cord Spinal Cord - drug effects Spinal Cord - metabolism Sulfhydryl Compounds - metabolism Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors
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