The effect of optimization HCl addition to dispersibility in carbon nanotubes functionalization as drug delivery
Carbon nanotube (CNT) is a breakthrough of cancer drug delivery which is able towards into targeted cells while minimizing normal cells damage apart from cancer cells. CNT has the ability for high anticancer drug loading and high targeting delivery without causing side effects. Functionalization pro...
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| creator | Wulan, P. P. D. K. Permana, G. Putri, W. A. |
| description | Carbon nanotube (CNT) is a breakthrough of cancer drug delivery which is able towards into targeted cells while minimizing normal cells damage apart from cancer cells. CNT has the ability for high anticancer drug loading and high targeting delivery without causing side effects. Functionalization process is required to elevate the dispersibility of CNT as a drug delivery due to the CNT limitation which not matched the standard of drug delivery system, such as dispersibility. This study aims to obtain the effect of hydrochloric acid (HCl) molarity optimization to the dispersibility of functionalized CNT (f-CNT). f-CNT is functionalized using a mixture of 6M HNO3 and 6M H2SO4. Variation were performed at HCl molarity which consist of 6M, 8M, 10M, and 12 M. The greatest HCl molarity is f-CNT which does not damage the morphology of CNT, has a high stability of dispersion, and impurities-free. Functionalized CNT (CNT-f) were characterized by Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy-Energy Dispersive Spectroscopy (SEM-EDS), and dispersion tests. The characterization resulted f-CNT with HCl molarity of 10M has the greatest oxygen percentage with 6,84% dispersibility for more than 24 days. |
| doi_str_mv | 10.1063/5.0014074 |
| format | Conference Proceeding |
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P. D. K. ; Permana, G. ; Putri, W. A.</creator><contributor>Nugraha, I Gde Dharma ; Kusrini, Eny</contributor><creatorcontrib>Wulan, P. P. D. K. ; Permana, G. ; Putri, W. A. ; Nugraha, I Gde Dharma ; Kusrini, Eny</creatorcontrib><description>Carbon nanotube (CNT) is a breakthrough of cancer drug delivery which is able towards into targeted cells while minimizing normal cells damage apart from cancer cells. CNT has the ability for high anticancer drug loading and high targeting delivery without causing side effects. Functionalization process is required to elevate the dispersibility of CNT as a drug delivery due to the CNT limitation which not matched the standard of drug delivery system, such as dispersibility. This study aims to obtain the effect of hydrochloric acid (HCl) molarity optimization to the dispersibility of functionalized CNT (f-CNT). f-CNT is functionalized using a mixture of 6M HNO3 and 6M H2SO4. Variation were performed at HCl molarity which consist of 6M, 8M, 10M, and 12 M. The greatest HCl molarity is f-CNT which does not damage the morphology of CNT, has a high stability of dispersion, and impurities-free. Functionalized CNT (CNT-f) were characterized by Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy-Energy Dispersive Spectroscopy (SEM-EDS), and dispersion tests. The characterization resulted f-CNT with HCl molarity of 10M has the greatest oxygen percentage with 6,84% dispersibility for more than 24 days.</description><identifier>ISSN: 0094-243X</identifier><identifier>EISSN: 1551-7616</identifier><identifier>DOI: 10.1063/5.0014074</identifier><identifier>CODEN: APCPCS</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>Carbon nanotubes ; Damage ; Dispersion ; Drug delivery systems ; Fourier transforms ; Hydrochloric acid ; Morphology ; Optimization ; Side effects ; Spectrum analysis ; Sulfuric acid</subject><ispartof>AIP conference proceedings, 2020, Vol.2255 (1)</ispartof><rights>Author(s)</rights><rights>2020 Author(s). 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A.</creatorcontrib><title>The effect of optimization HCl addition to dispersibility in carbon nanotubes functionalization as drug delivery</title><title>AIP conference proceedings</title><description>Carbon nanotube (CNT) is a breakthrough of cancer drug delivery which is able towards into targeted cells while minimizing normal cells damage apart from cancer cells. CNT has the ability for high anticancer drug loading and high targeting delivery without causing side effects. Functionalization process is required to elevate the dispersibility of CNT as a drug delivery due to the CNT limitation which not matched the standard of drug delivery system, such as dispersibility. This study aims to obtain the effect of hydrochloric acid (HCl) molarity optimization to the dispersibility of functionalized CNT (f-CNT). f-CNT is functionalized using a mixture of 6M HNO3 and 6M H2SO4. Variation were performed at HCl molarity which consist of 6M, 8M, 10M, and 12 M. The greatest HCl molarity is f-CNT which does not damage the morphology of CNT, has a high stability of dispersion, and impurities-free. Functionalized CNT (CNT-f) were characterized by Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy-Energy Dispersive Spectroscopy (SEM-EDS), and dispersion tests. The characterization resulted f-CNT with HCl molarity of 10M has the greatest oxygen percentage with 6,84% dispersibility for more than 24 days.</description><subject>Carbon nanotubes</subject><subject>Damage</subject><subject>Dispersion</subject><subject>Drug delivery systems</subject><subject>Fourier transforms</subject><subject>Hydrochloric acid</subject><subject>Morphology</subject><subject>Optimization</subject><subject>Side effects</subject><subject>Spectrum analysis</subject><subject>Sulfuric acid</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2020</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNp9kE1LAzEQhoMoWKsH_0HAm7B18rGb3aMUtULBSwVvIbtJNGW7WZNsof56t7XizbkMwzy8vDwIXROYESjYXT4DIBwEP0ETkuckEwUpTtEEoOIZ5eztHF3EuAaglRDlBPWrD4ONtaZJ2Fvs--Q27ksl5zu8mLdYae0OR_JYu9ibEF3tWpd22HW4UaEef53qfBpqE7EdumaPq_Y3REWsw_COtWnd1oTdJTqzqo3m6rin6PXxYTVfZMuXp-f5_TJraMVSZsuiqisqmGKloYYRA9yC1YUqBZSc01zUBsahigswRChLuapzBqQutRZsim5-cvvgPwcTk1z7IYzFohw1VIKVDGCkbn-o2Lh0KCz74DYq7CQBuTcqc3k0-h-89eEPlL227BsD0ngJ</recordid><startdate>20200903</startdate><enddate>20200903</enddate><creator>Wulan, P. P. D. K.</creator><creator>Permana, G.</creator><creator>Putri, W. A.</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20200903</creationdate><title>The effect of optimization HCl addition to dispersibility in carbon nanotubes functionalization as drug delivery</title><author>Wulan, P. P. D. K. ; Permana, G. ; Putri, W. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-f869b9273a38e2e31e04f0fd6a870844257be00002a470e17af24ab5301b8dd73</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Carbon nanotubes</topic><topic>Damage</topic><topic>Dispersion</topic><topic>Drug delivery systems</topic><topic>Fourier transforms</topic><topic>Hydrochloric acid</topic><topic>Morphology</topic><topic>Optimization</topic><topic>Side effects</topic><topic>Spectrum analysis</topic><topic>Sulfuric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wulan, P. P. D. K.</creatorcontrib><creatorcontrib>Permana, G.</creatorcontrib><creatorcontrib>Putri, W. A.</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wulan, P. P. D. K.</au><au>Permana, G.</au><au>Putri, W. A.</au><au>Nugraha, I Gde Dharma</au><au>Kusrini, Eny</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>The effect of optimization HCl addition to dispersibility in carbon nanotubes functionalization as drug delivery</atitle><btitle>AIP conference proceedings</btitle><date>2020-09-03</date><risdate>2020</risdate><volume>2255</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><coden>APCPCS</coden><abstract>Carbon nanotube (CNT) is a breakthrough of cancer drug delivery which is able towards into targeted cells while minimizing normal cells damage apart from cancer cells. CNT has the ability for high anticancer drug loading and high targeting delivery without causing side effects. Functionalization process is required to elevate the dispersibility of CNT as a drug delivery due to the CNT limitation which not matched the standard of drug delivery system, such as dispersibility. This study aims to obtain the effect of hydrochloric acid (HCl) molarity optimization to the dispersibility of functionalized CNT (f-CNT). f-CNT is functionalized using a mixture of 6M HNO3 and 6M H2SO4. Variation were performed at HCl molarity which consist of 6M, 8M, 10M, and 12 M. The greatest HCl molarity is f-CNT which does not damage the morphology of CNT, has a high stability of dispersion, and impurities-free. Functionalized CNT (CNT-f) were characterized by Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy-Energy Dispersive Spectroscopy (SEM-EDS), and dispersion tests. The characterization resulted f-CNT with HCl molarity of 10M has the greatest oxygen percentage with 6,84% dispersibility for more than 24 days.</abstract><cop>Melville</cop><pub>American Institute of Physics</pub><doi>10.1063/5.0014074</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0094-243X |
| ispartof | AIP conference proceedings, 2020, Vol.2255 (1) |
| issn | 0094-243X 1551-7616 |
| language | eng |
| recordid | cdi_proquest_journals_2439738300 |
| source | AIP Journals Complete |
| subjects | Carbon nanotubes Damage Dispersion Drug delivery systems Fourier transforms Hydrochloric acid Morphology Optimization Side effects Spectrum analysis Sulfuric acid |
| title | The effect of optimization HCl addition to dispersibility in carbon nanotubes functionalization as drug delivery |
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