Zinc(II) halide and copper(II) bromide complexes with caffeine: structures, physicochemical properties, and biological activity
This study provides a comparative characterization of the structural parameters and cytotoxicity of zinc halide and copper(II) bromide complexes with caffeine (caf) of the composition [Zn(caf)(H 2 O)X 2 ] (X = Cl, Br, I) and [Cu(caf) 2 Br 2 ] (1). The cytotoxicity of the complexes is dose-dependent...
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| Veröffentlicht in: | Russian chemical bulletin 2020-07, Vol.69 (7), p.1394-1400 |
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| creator | Rukk, N. S. Kuzmina, L. G. Davydova, G. A. Buzanov, G. A. Belus, S. K. Kozhukhova, E. I. Retivov, V. M. Ivanova, T. V. Krasnoperova, V. N. Bolotin, B. M. |
| description | This study provides a comparative characterization of the structural parameters and cytotoxicity of zinc halide and copper(II) bromide complexes with caffeine (caf) of the composition [Zn(caf)(H
2
O)X
2
] (X = Cl, Br, I) and [Cu(caf)
2
Br
2
]
(1).
The cytotoxicity of the complexes is dose-dependent in all cell lines. The concentrations of the complexes, at which they are more cytotoxic against cancer cells (MCF-7) than against stem cells (DPSC), were determined. The synthesized complexes exhibited synergism of cytotoxicity. |
| doi_str_mv | 10.1007/s11172-020-2914-4 |
| format | Article |
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2
O)X
2
] (X = Cl, Br, I) and [Cu(caf)
2
Br
2
]
(1).
The cytotoxicity of the complexes is dose-dependent in all cell lines. The concentrations of the complexes, at which they are more cytotoxic against cancer cells (MCF-7) than against stem cells (DPSC), were determined. The synthesized complexes exhibited synergism of cytotoxicity.</description><identifier>ISSN: 1066-5285</identifier><identifier>EISSN: 1573-9171</identifier><identifier>DOI: 10.1007/s11172-020-2914-4</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biological activity ; Biological properties ; Caffeine ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Coordination compounds ; Copper bromide ; Copper compounds ; Cytotoxicity ; Full Articles ; Inorganic Chemistry ; Organic Chemistry ; Stem cells ; Structural analysis ; Toxicity ; Zinc</subject><ispartof>Russian chemical bulletin, 2020-07, Vol.69 (7), p.1394-1400</ispartof><rights>Springer Science+Business Media LLC 2020</rights><rights>Springer Science+Business Media LLC 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-a3b043c17b1e1a2a1523fc4b3ba67f202b9d2fde9ac9319456cb07cb5ea721303</citedby><cites>FETCH-LOGICAL-c316t-a3b043c17b1e1a2a1523fc4b3ba67f202b9d2fde9ac9319456cb07cb5ea721303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11172-020-2914-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11172-020-2914-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Rukk, N. S.</creatorcontrib><creatorcontrib>Kuzmina, L. G.</creatorcontrib><creatorcontrib>Davydova, G. A.</creatorcontrib><creatorcontrib>Buzanov, G. A.</creatorcontrib><creatorcontrib>Belus, S. K.</creatorcontrib><creatorcontrib>Kozhukhova, E. I.</creatorcontrib><creatorcontrib>Retivov, V. M.</creatorcontrib><creatorcontrib>Ivanova, T. V.</creatorcontrib><creatorcontrib>Krasnoperova, V. N.</creatorcontrib><creatorcontrib>Bolotin, B. M.</creatorcontrib><title>Zinc(II) halide and copper(II) bromide complexes with caffeine: structures, physicochemical properties, and biological activity</title><title>Russian chemical bulletin</title><addtitle>Russ Chem Bull</addtitle><description>This study provides a comparative characterization of the structural parameters and cytotoxicity of zinc halide and copper(II) bromide complexes with caffeine (caf) of the composition [Zn(caf)(H
2
O)X
2
] (X = Cl, Br, I) and [Cu(caf)
2
Br
2
]
(1).
The cytotoxicity of the complexes is dose-dependent in all cell lines. The concentrations of the complexes, at which they are more cytotoxic against cancer cells (MCF-7) than against stem cells (DPSC), were determined. The synthesized complexes exhibited synergism of cytotoxicity.</description><subject>Biological activity</subject><subject>Biological properties</subject><subject>Caffeine</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Coordination compounds</subject><subject>Copper bromide</subject><subject>Copper compounds</subject><subject>Cytotoxicity</subject><subject>Full Articles</subject><subject>Inorganic Chemistry</subject><subject>Organic Chemistry</subject><subject>Stem cells</subject><subject>Structural analysis</subject><subject>Toxicity</subject><subject>Zinc</subject><issn>1066-5285</issn><issn>1573-9171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1UEtLxDAQDqLguvoDvBW8KFjNJG3TepPFx4LgRS9eQpKm2yxtU5Osuif_uu1W8ORphu81w4fQKeArwJhdewBgJMYEx6SAJE720AxSRuMCGOwPO86yOCV5eoiOvF9jjEme5zP0_WY6db5cXkS1aEypI9GVkbJ9r90Olc62I6xs2zf6S_vo04Q6UqKqtOn0TeSD26iwcdpfRn299UZZVevWKNFEvbNDTjAjN-ZKYxu72lFCBfNhwvYYHVSi8frkd87R6_3dy-Ixfnp-WC5un2JFIQuxoBInVAGToEEQASmhlUoklSJjFcFEFiWpSl0IVVAokjRTEjMlUy0YAYrpHJ1NucNP7xvtA1_bjeuGk5wktMgooyQfVDCplLPeO13x3plWuC0HzMee-dQzH3rmY888GTxk8vhB2620-0v-3_QDe-eBkg</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Rukk, N. S.</creator><creator>Kuzmina, L. G.</creator><creator>Davydova, G. A.</creator><creator>Buzanov, G. A.</creator><creator>Belus, S. K.</creator><creator>Kozhukhova, E. I.</creator><creator>Retivov, V. M.</creator><creator>Ivanova, T. V.</creator><creator>Krasnoperova, V. N.</creator><creator>Bolotin, B. M.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200701</creationdate><title>Zinc(II) halide and copper(II) bromide complexes with caffeine: structures, physicochemical properties, and biological activity</title><author>Rukk, N. S. ; Kuzmina, L. G. ; Davydova, G. A. ; Buzanov, G. A. ; Belus, S. K. ; Kozhukhova, E. I. ; Retivov, V. M. ; Ivanova, T. V. ; Krasnoperova, V. N. ; Bolotin, B. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-a3b043c17b1e1a2a1523fc4b3ba67f202b9d2fde9ac9319456cb07cb5ea721303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biological activity</topic><topic>Biological properties</topic><topic>Caffeine</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Coordination compounds</topic><topic>Copper bromide</topic><topic>Copper compounds</topic><topic>Cytotoxicity</topic><topic>Full Articles</topic><topic>Inorganic Chemistry</topic><topic>Organic Chemistry</topic><topic>Stem cells</topic><topic>Structural analysis</topic><topic>Toxicity</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rukk, N. S.</creatorcontrib><creatorcontrib>Kuzmina, L. G.</creatorcontrib><creatorcontrib>Davydova, G. A.</creatorcontrib><creatorcontrib>Buzanov, G. A.</creatorcontrib><creatorcontrib>Belus, S. K.</creatorcontrib><creatorcontrib>Kozhukhova, E. I.</creatorcontrib><creatorcontrib>Retivov, V. M.</creatorcontrib><creatorcontrib>Ivanova, T. V.</creatorcontrib><creatorcontrib>Krasnoperova, V. N.</creatorcontrib><creatorcontrib>Bolotin, B. M.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian chemical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rukk, N. S.</au><au>Kuzmina, L. G.</au><au>Davydova, G. A.</au><au>Buzanov, G. A.</au><au>Belus, S. K.</au><au>Kozhukhova, E. I.</au><au>Retivov, V. M.</au><au>Ivanova, T. V.</au><au>Krasnoperova, V. N.</au><au>Bolotin, B. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zinc(II) halide and copper(II) bromide complexes with caffeine: structures, physicochemical properties, and biological activity</atitle><jtitle>Russian chemical bulletin</jtitle><stitle>Russ Chem Bull</stitle><date>2020-07-01</date><risdate>2020</risdate><volume>69</volume><issue>7</issue><spage>1394</spage><epage>1400</epage><pages>1394-1400</pages><issn>1066-5285</issn><eissn>1573-9171</eissn><abstract>This study provides a comparative characterization of the structural parameters and cytotoxicity of zinc halide and copper(II) bromide complexes with caffeine (caf) of the composition [Zn(caf)(H
2
O)X
2
] (X = Cl, Br, I) and [Cu(caf)
2
Br
2
]
(1).
The cytotoxicity of the complexes is dose-dependent in all cell lines. The concentrations of the complexes, at which they are more cytotoxic against cancer cells (MCF-7) than against stem cells (DPSC), were determined. The synthesized complexes exhibited synergism of cytotoxicity.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11172-020-2914-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Biological activity Biological properties Caffeine Chemistry Chemistry and Materials Science Chemistry/Food Science Coordination compounds Copper bromide Copper compounds Cytotoxicity Full Articles Inorganic Chemistry Organic Chemistry Stem cells Structural analysis Toxicity Zinc |
| title | Zinc(II) halide and copper(II) bromide complexes with caffeine: structures, physicochemical properties, and biological activity |
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