Toxicity of food flavorings to ex-vivo, in vitro and in vivo bioassays
This study evaluated the toxicity of food flavorings of mint, cinnamon and lemon in meristem root cells of Allium cepa, in pure form (as marketed) and in the concentrations of 12.5, 25, and 50%, after 24 and 48 hours of exposure; in Vero cell culture evaluated by MTT test and in nauplii of Artemia s...
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| Veröffentlicht in: | Acta scientiarum. Technology 2020-01, Vol.42, p.e44867 |
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| container_title | Acta scientiarum. Technology |
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| creator | Santos, Fabelina Karollyne da Silva dos Marques, Márcia Maria Mendes Van Tilbulrg, Maurício Fraga Guedes, Maria Izabel Florindo Bueno, Paulo Agenor Alves Peron, Ana Paula |
| description | This study evaluated the toxicity of food flavorings of mint, cinnamon and lemon in meristem root cells of Allium cepa, in pure form (as marketed) and in the concentrations of 12.5, 25, and 50%, after 24 and 48 hours of exposure; in Vero cell culture evaluated by MTT test and in nauplii of Artemia salina, both tests used flavorings in pure form and in the concentrations of 0.78, 1.56, 3.12, 6.25, 12.5, 25, and 50%, after 24 hours of exposure. The three flavorings, in all treatments and times of analysis considered, caused significant inhibition of cell division. However, the flavorings did not cause cellular alterations to the evaluated meristems. All evaluated treatments significantly reduced the viability of the evaluated cell line and promoted 100% lethality of A. salina nauplii. The evaluated flavorings, under the established study conditions, promoted wide and significant toxicity. |
| doi_str_mv | 10.4025/actascitechnol.v42i1.44867 |
| format | Article |
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The three flavorings, in all treatments and times of analysis considered, caused significant inhibition of cell division. However, the flavorings did not cause cellular alterations to the evaluated meristems. All evaluated treatments significantly reduced the viability of the evaluated cell line and promoted 100% lethality of A. salina nauplii. The evaluated flavorings, under the established study conditions, promoted wide and significant toxicity.</description><identifier>ISSN: 1806-2563</identifier><identifier>EISSN: 1807-8664</identifier><identifier>EISSN: 1806-2563</identifier><identifier>DOI: 10.4025/actascitechnol.v42i1.44867</identifier><language>eng</language><publisher>Maringa: Editora da Universidade Estadual de Maringá - EDUEM</publisher><subject>Artemia ; Biocompatibility ; Cell division ; Food ; In vivo methods and tests ; Lemons ; Lethality ; Toxicity</subject><ispartof>Acta scientiarum. Technology, 2020-01, Vol.42, p.e44867</ispartof><rights>2020. 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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Artemia Biocompatibility Cell division Food In vivo methods and tests Lemons Lethality Toxicity |
| title | Toxicity of food flavorings to ex-vivo, in vitro and in vivo bioassays |
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