N-Propargylation and Copper(I)-Catalyzed Azide-Alkyne Cycloaddition as a Convenient Strategy for Directed Post-Synthetic Modification of 4-Oxo-1,4-Dihydrocinnoline Derivatives

4-Oxo-1,4-dihydrocinnoline derivatives as promising inhibitors of protein tyrosine phosphatase 1В were subjected to post-synthetic modification via a sequence of propargylation and copper(I)-catalyzed azide-alkyne cycloaddition reactions. The propargylation of 4-oxo- 1,4-dihydrocinnolines with propa...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2020-07, Vol.56 (7), p.915-922
Hauptverfasser:	Mikhaylov, Vladimir N., Pavlov, Artem O., Ogorodnov, Yaroslav V., Spiridonova, Dar’ya V., Sorokoumov, Viktor N., Balova, Irina A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Catalytic activity Chemical reactions Chemistry Chemistry and Materials Science Coordination compounds Copper Cycloaddition Derivatives Leptin Organic Chemistry Pharmacy Phosphatases Tyrosine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!