Distinct Metabolic Profile of Inhaled Budesonide and Salbutamol in Asthmatic Children during Acute Exacerbation
Inhaled budesonide and salbutamol represent the most important and frequently used drugs in asthmatic children during acute exacerbation. However, there is still no consensus about their resulting metabolic derangements; thus, this study was conducted to determine the distinct metabolic profiles of...
Gespeichert in:
| Veröffentlicht in: | Basic & clinical pharmacology & toxicology 2017-03, Vol.120 (3), p.303-311 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 311 |
|---|---|
| container_issue | 3 |
| container_start_page | 303 |
| container_title | Basic & clinical pharmacology & toxicology |
| container_volume | 120 |
| creator | Quan‐Jun, Yang Jian‐Ping, Zhang Jian‐Hua, Zhang Yong‐Long, Han Bo, Xin Jing‐Xian, Zhang Bona, Dai Yuan, Zhang Cheng, Guo |
| description | Inhaled budesonide and salbutamol represent the most important and frequently used drugs in asthmatic children during acute exacerbation. However, there is still no consensus about their resulting metabolic derangements; thus, this study was conducted to determine the distinct metabolic profiles of these two drugs. A total of 69 children with asthma during acute exacerbation were included, and their serum and urine were investigated using high‐resolution nuclear magnetic resonance (NMR). A metabolomics analysis was performed using a principal component analysis and orthogonal signal correction–partial least squares using SIMCA‐P. The different metabolites were identified, and the distinct metabolic profiles were analysed using MetPA. A high‐resolution NMR‐based serum and urine metabolomics approach was established to study the overall metabolic changes after inhaled budesonide and salbutamol in asthmatic children during acute exacerbation. The perturbed metabolites included 22 different metabolites in the serum and 21 metabolites in the urine. Based on an integrated analysis, the changed metabolites included the following: increased 4‐hydroxybutyrate, lactate, cis‐aconitate, 5‐hydroxyindoleacetate, taurine, trans‐4‐hydroxy‐l‐proline, tiglylglycine, 3‐hydroxybutyrate, 3‐methylhistidine, glucose, cis‐aconitate, 2‐deoxyinosine and 2‐aminoadipate; and decreased alanine, glycerol, arginine, glycylproline, 2‐hydroxy‐3‐methylvalerate, creatine, citrulline, glutamate, asparagine, 2‐hydroxyvalerate, citrate, homoserine, histamine, sn‐glycero‐3‐phosphocholine, sarcosine, ornithine, creatinine, glycine, isoleucine and trimethylamine N‐oxide. The MetPA analysis revealed seven involved metabolic pathways: arginine and proline metabolism; taurine and hypotaurine metabolism; glycine, serine and threonine metabolism; glyoxylate and dicarboxylate metabolism; methane metabolism; citrate cycle; and pyruvate metabolism. The perturbed metabolic profiles suggest potential metabolic reprogramming associated with a combination treatment of inhaled budesonide and salbutamol in asthmatic children. |
| doi_str_mv | 10.1111/bcpt.12686 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2438563340</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2438563340</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4216-a0a4b6f88e22925010e0ef8b22793ff87fdfe8ac1cbe0c30ef47edeb0b6ef42b3</originalsourceid><addsrcrecordid>eNp9kUtPWzEQha2KqjzaTX8AssSuUqhfsc0ypLwkqiKVrq_8GDdGN3awfQX8e0xDWTKbGWm-OSOdg9BXSo5pr-_WbdoxZVLLD2iPKsFmSgu-8zbz-S7ar_WOEKYEJZ_QLlOKEyXkHso_Ym0xuYZ_QjM2j9Hhm5JDHAHngK_Syozg8enkoeYUPWCTPP5tRjs1s84jjgkvalutTeuXy1UcfYGE_VRi-osXbmqAzx6Ng2I7kdNn9DGYscKX136A_pyf3S4vZ9e_Lq6Wi-uZE4zKmSFGWBm0BsZO2JxQAgSCtoypEx6CVsEH0MZRZ4E43ndCgQdLrOwjs_wAHW11NyXfT1DbcJenkvrLgQmu55JzQd6jqJaSMM6V6NS3LeVKrrVAGDYlrk15GigZXhIYXhIY_iXQ4cNXycmuwb-h_y3vAN0CD93jp3ekhtPlze1W9Blab5GR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1866023374</pqid></control><display><type>article</type><title>Distinct Metabolic Profile of Inhaled Budesonide and Salbutamol in Asthmatic Children during Acute Exacerbation</title><source>MEDLINE</source><source>Wiley Online Library Journals</source><source>Alma/SFX Local Collection</source><creator>Quan‐Jun, Yang ; Jian‐Ping, Zhang ; Jian‐Hua, Zhang ; Yong‐Long, Han ; Bo, Xin ; Jing‐Xian, Zhang ; Bona, Dai ; Yuan, Zhang ; Cheng, Guo</creator><creatorcontrib>Quan‐Jun, Yang ; Jian‐Ping, Zhang ; Jian‐Hua, Zhang ; Yong‐Long, Han ; Bo, Xin ; Jing‐Xian, Zhang ; Bona, Dai ; Yuan, Zhang ; Cheng, Guo</creatorcontrib><description>Inhaled budesonide and salbutamol represent the most important and frequently used drugs in asthmatic children during acute exacerbation. However, there is still no consensus about their resulting metabolic derangements; thus, this study was conducted to determine the distinct metabolic profiles of these two drugs. A total of 69 children with asthma during acute exacerbation were included, and their serum and urine were investigated using high‐resolution nuclear magnetic resonance (NMR). A metabolomics analysis was performed using a principal component analysis and orthogonal signal correction–partial least squares using SIMCA‐P. The different metabolites were identified, and the distinct metabolic profiles were analysed using MetPA. A high‐resolution NMR‐based serum and urine metabolomics approach was established to study the overall metabolic changes after inhaled budesonide and salbutamol in asthmatic children during acute exacerbation. The perturbed metabolites included 22 different metabolites in the serum and 21 metabolites in the urine. Based on an integrated analysis, the changed metabolites included the following: increased 4‐hydroxybutyrate, lactate, cis‐aconitate, 5‐hydroxyindoleacetate, taurine, trans‐4‐hydroxy‐l‐proline, tiglylglycine, 3‐hydroxybutyrate, 3‐methylhistidine, glucose, cis‐aconitate, 2‐deoxyinosine and 2‐aminoadipate; and decreased alanine, glycerol, arginine, glycylproline, 2‐hydroxy‐3‐methylvalerate, creatine, citrulline, glutamate, asparagine, 2‐hydroxyvalerate, citrate, homoserine, histamine, sn‐glycero‐3‐phosphocholine, sarcosine, ornithine, creatinine, glycine, isoleucine and trimethylamine N‐oxide. The MetPA analysis revealed seven involved metabolic pathways: arginine and proline metabolism; taurine and hypotaurine metabolism; glycine, serine and threonine metabolism; glyoxylate and dicarboxylate metabolism; methane metabolism; citrate cycle; and pyruvate metabolism. The perturbed metabolic profiles suggest potential metabolic reprogramming associated with a combination treatment of inhaled budesonide and salbutamol in asthmatic children.</description><identifier>ISSN: 1742-7835</identifier><identifier>EISSN: 1742-7843</identifier><identifier>DOI: 10.1111/bcpt.12686</identifier><identifier>PMID: 27730746</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Administration, Inhalation ; Adrenergic beta-2 Receptor Agonists - administration & dosage ; Adrenergic beta-2 Receptor Agonists - pharmacokinetics ; Alanine ; Albuterol - administration & dosage ; Albuterol - pharmacokinetics ; Arginine ; Asparagine ; Asthma ; Asthma - blood ; Asthma - drug therapy ; Asthma - urine ; Bronchodilator Agents - administration & dosage ; Bronchodilator Agents - pharmacokinetics ; Budesonide ; Budesonide - administration & dosage ; Budesonide - pharmacokinetics ; Child ; Child, Preschool ; Children ; China ; Citric acid ; Citrulline ; Creatine ; Creatinine ; Disease Progression ; Drugs ; Glucocorticoids - administration & dosage ; Glucocorticoids - metabolism ; Glycerol ; Glycine ; Histamine ; Humans ; Infant ; Isoleucine ; Lactic acid ; Magnetic Resonance Spectroscopy ; Male ; Metabolic pathways ; Metabolism ; Metabolites ; Metabolome ; Metabolomics ; Metabolomics - methods ; Multivariate Analysis ; NMR ; Nuclear magnetic resonance ; Ornithine ; Phosphocholine ; Principal components analysis ; Proline ; Pyruvic acid ; Respiratory therapy ; Salbutamol ; Sarcosine ; Trimethylamine ; Urine</subject><ispartof>Basic & clinical pharmacology & toxicology, 2017-03, Vol.120 (3), p.303-311</ispartof><rights>2016 The Authors. published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society)</rights><rights>2016 The Authors. Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).</rights><rights>Copyright © 2017 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd.</rights><rights>2016. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4216-a0a4b6f88e22925010e0ef8b22793ff87fdfe8ac1cbe0c30ef47edeb0b6ef42b3</citedby><cites>FETCH-LOGICAL-c4216-a0a4b6f88e22925010e0ef8b22793ff87fdfe8ac1cbe0c30ef47edeb0b6ef42b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbcpt.12686$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbcpt.12686$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27730746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quan‐Jun, Yang</creatorcontrib><creatorcontrib>Jian‐Ping, Zhang</creatorcontrib><creatorcontrib>Jian‐Hua, Zhang</creatorcontrib><creatorcontrib>Yong‐Long, Han</creatorcontrib><creatorcontrib>Bo, Xin</creatorcontrib><creatorcontrib>Jing‐Xian, Zhang</creatorcontrib><creatorcontrib>Bona, Dai</creatorcontrib><creatorcontrib>Yuan, Zhang</creatorcontrib><creatorcontrib>Cheng, Guo</creatorcontrib><title>Distinct Metabolic Profile of Inhaled Budesonide and Salbutamol in Asthmatic Children during Acute Exacerbation</title><title>Basic & clinical pharmacology & toxicology</title><addtitle>Basic Clin Pharmacol Toxicol</addtitle><description>Inhaled budesonide and salbutamol represent the most important and frequently used drugs in asthmatic children during acute exacerbation. However, there is still no consensus about their resulting metabolic derangements; thus, this study was conducted to determine the distinct metabolic profiles of these two drugs. A total of 69 children with asthma during acute exacerbation were included, and their serum and urine were investigated using high‐resolution nuclear magnetic resonance (NMR). A metabolomics analysis was performed using a principal component analysis and orthogonal signal correction–partial least squares using SIMCA‐P. The different metabolites were identified, and the distinct metabolic profiles were analysed using MetPA. A high‐resolution NMR‐based serum and urine metabolomics approach was established to study the overall metabolic changes after inhaled budesonide and salbutamol in asthmatic children during acute exacerbation. The perturbed metabolites included 22 different metabolites in the serum and 21 metabolites in the urine. Based on an integrated analysis, the changed metabolites included the following: increased 4‐hydroxybutyrate, lactate, cis‐aconitate, 5‐hydroxyindoleacetate, taurine, trans‐4‐hydroxy‐l‐proline, tiglylglycine, 3‐hydroxybutyrate, 3‐methylhistidine, glucose, cis‐aconitate, 2‐deoxyinosine and 2‐aminoadipate; and decreased alanine, glycerol, arginine, glycylproline, 2‐hydroxy‐3‐methylvalerate, creatine, citrulline, glutamate, asparagine, 2‐hydroxyvalerate, citrate, homoserine, histamine, sn‐glycero‐3‐phosphocholine, sarcosine, ornithine, creatinine, glycine, isoleucine and trimethylamine N‐oxide. The MetPA analysis revealed seven involved metabolic pathways: arginine and proline metabolism; taurine and hypotaurine metabolism; glycine, serine and threonine metabolism; glyoxylate and dicarboxylate metabolism; methane metabolism; citrate cycle; and pyruvate metabolism. The perturbed metabolic profiles suggest potential metabolic reprogramming associated with a combination treatment of inhaled budesonide and salbutamol in asthmatic children.</description><subject>Administration, Inhalation</subject><subject>Adrenergic beta-2 Receptor Agonists - administration & dosage</subject><subject>Adrenergic beta-2 Receptor Agonists - pharmacokinetics</subject><subject>Alanine</subject><subject>Albuterol - administration & dosage</subject><subject>Albuterol - pharmacokinetics</subject><subject>Arginine</subject><subject>Asparagine</subject><subject>Asthma</subject><subject>Asthma - blood</subject><subject>Asthma - drug therapy</subject><subject>Asthma - urine</subject><subject>Bronchodilator Agents - administration & dosage</subject><subject>Bronchodilator Agents - pharmacokinetics</subject><subject>Budesonide</subject><subject>Budesonide - administration & dosage</subject><subject>Budesonide - pharmacokinetics</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>China</subject><subject>Citric acid</subject><subject>Citrulline</subject><subject>Creatine</subject><subject>Creatinine</subject><subject>Disease Progression</subject><subject>Drugs</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Glucocorticoids - metabolism</subject><subject>Glycerol</subject><subject>Glycine</subject><subject>Histamine</subject><subject>Humans</subject><subject>Infant</subject><subject>Isoleucine</subject><subject>Lactic acid</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Metabolic pathways</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolome</subject><subject>Metabolomics</subject><subject>Metabolomics - methods</subject><subject>Multivariate Analysis</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Ornithine</subject><subject>Phosphocholine</subject><subject>Principal components analysis</subject><subject>Proline</subject><subject>Pyruvic acid</subject><subject>Respiratory therapy</subject><subject>Salbutamol</subject><subject>Sarcosine</subject><subject>Trimethylamine</subject><subject>Urine</subject><issn>1742-7835</issn><issn>1742-7843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kUtPWzEQha2KqjzaTX8AssSuUqhfsc0ypLwkqiKVrq_8GDdGN3awfQX8e0xDWTKbGWm-OSOdg9BXSo5pr-_WbdoxZVLLD2iPKsFmSgu-8zbz-S7ar_WOEKYEJZ_QLlOKEyXkHso_Ym0xuYZ_QjM2j9Hhm5JDHAHngK_Syozg8enkoeYUPWCTPP5tRjs1s84jjgkvalutTeuXy1UcfYGE_VRi-osXbmqAzx6Ng2I7kdNn9DGYscKX136A_pyf3S4vZ9e_Lq6Wi-uZE4zKmSFGWBm0BsZO2JxQAgSCtoypEx6CVsEH0MZRZ4E43ndCgQdLrOwjs_wAHW11NyXfT1DbcJenkvrLgQmu55JzQd6jqJaSMM6V6NS3LeVKrrVAGDYlrk15GigZXhIYXhIY_iXQ4cNXycmuwb-h_y3vAN0CD93jp3ekhtPlze1W9Blab5GR</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Quan‐Jun, Yang</creator><creator>Jian‐Ping, Zhang</creator><creator>Jian‐Hua, Zhang</creator><creator>Yong‐Long, Han</creator><creator>Bo, Xin</creator><creator>Jing‐Xian, Zhang</creator><creator>Bona, Dai</creator><creator>Yuan, Zhang</creator><creator>Cheng, Guo</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201703</creationdate><title>Distinct Metabolic Profile of Inhaled Budesonide and Salbutamol in Asthmatic Children during Acute Exacerbation</title><author>Quan‐Jun, Yang ; Jian‐Ping, Zhang ; Jian‐Hua, Zhang ; Yong‐Long, Han ; Bo, Xin ; Jing‐Xian, Zhang ; Bona, Dai ; Yuan, Zhang ; Cheng, Guo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4216-a0a4b6f88e22925010e0ef8b22793ff87fdfe8ac1cbe0c30ef47edeb0b6ef42b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Administration, Inhalation</topic><topic>Adrenergic beta-2 Receptor Agonists - administration & dosage</topic><topic>Adrenergic beta-2 Receptor Agonists - pharmacokinetics</topic><topic>Alanine</topic><topic>Albuterol - administration & dosage</topic><topic>Albuterol - pharmacokinetics</topic><topic>Arginine</topic><topic>Asparagine</topic><topic>Asthma</topic><topic>Asthma - blood</topic><topic>Asthma - drug therapy</topic><topic>Asthma - urine</topic><topic>Bronchodilator Agents - administration & dosage</topic><topic>Bronchodilator Agents - pharmacokinetics</topic><topic>Budesonide</topic><topic>Budesonide - administration & dosage</topic><topic>Budesonide - pharmacokinetics</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>China</topic><topic>Citric acid</topic><topic>Citrulline</topic><topic>Creatine</topic><topic>Creatinine</topic><topic>Disease Progression</topic><topic>Drugs</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Glucocorticoids - metabolism</topic><topic>Glycerol</topic><topic>Glycine</topic><topic>Histamine</topic><topic>Humans</topic><topic>Infant</topic><topic>Isoleucine</topic><topic>Lactic acid</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Metabolic pathways</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metabolome</topic><topic>Metabolomics</topic><topic>Metabolomics - methods</topic><topic>Multivariate Analysis</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Ornithine</topic><topic>Phosphocholine</topic><topic>Principal components analysis</topic><topic>Proline</topic><topic>Pyruvic acid</topic><topic>Respiratory therapy</topic><topic>Salbutamol</topic><topic>Sarcosine</topic><topic>Trimethylamine</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quan‐Jun, Yang</creatorcontrib><creatorcontrib>Jian‐Ping, Zhang</creatorcontrib><creatorcontrib>Jian‐Hua, Zhang</creatorcontrib><creatorcontrib>Yong‐Long, Han</creatorcontrib><creatorcontrib>Bo, Xin</creatorcontrib><creatorcontrib>Jing‐Xian, Zhang</creatorcontrib><creatorcontrib>Bona, Dai</creatorcontrib><creatorcontrib>Yuan, Zhang</creatorcontrib><creatorcontrib>Cheng, Guo</creatorcontrib><collection>Wiley Open Access</collection><collection>Wiley Free Archive</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Basic & clinical pharmacology & toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quan‐Jun, Yang</au><au>Jian‐Ping, Zhang</au><au>Jian‐Hua, Zhang</au><au>Yong‐Long, Han</au><au>Bo, Xin</au><au>Jing‐Xian, Zhang</au><au>Bona, Dai</au><au>Yuan, Zhang</au><au>Cheng, Guo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct Metabolic Profile of Inhaled Budesonide and Salbutamol in Asthmatic Children during Acute Exacerbation</atitle><jtitle>Basic & clinical pharmacology & toxicology</jtitle><addtitle>Basic Clin Pharmacol Toxicol</addtitle><date>2017-03</date><risdate>2017</risdate><volume>120</volume><issue>3</issue><spage>303</spage><epage>311</epage><pages>303-311</pages><issn>1742-7835</issn><eissn>1742-7843</eissn><abstract>Inhaled budesonide and salbutamol represent the most important and frequently used drugs in asthmatic children during acute exacerbation. However, there is still no consensus about their resulting metabolic derangements; thus, this study was conducted to determine the distinct metabolic profiles of these two drugs. A total of 69 children with asthma during acute exacerbation were included, and their serum and urine were investigated using high‐resolution nuclear magnetic resonance (NMR). A metabolomics analysis was performed using a principal component analysis and orthogonal signal correction–partial least squares using SIMCA‐P. The different metabolites were identified, and the distinct metabolic profiles were analysed using MetPA. A high‐resolution NMR‐based serum and urine metabolomics approach was established to study the overall metabolic changes after inhaled budesonide and salbutamol in asthmatic children during acute exacerbation. The perturbed metabolites included 22 different metabolites in the serum and 21 metabolites in the urine. Based on an integrated analysis, the changed metabolites included the following: increased 4‐hydroxybutyrate, lactate, cis‐aconitate, 5‐hydroxyindoleacetate, taurine, trans‐4‐hydroxy‐l‐proline, tiglylglycine, 3‐hydroxybutyrate, 3‐methylhistidine, glucose, cis‐aconitate, 2‐deoxyinosine and 2‐aminoadipate; and decreased alanine, glycerol, arginine, glycylproline, 2‐hydroxy‐3‐methylvalerate, creatine, citrulline, glutamate, asparagine, 2‐hydroxyvalerate, citrate, homoserine, histamine, sn‐glycero‐3‐phosphocholine, sarcosine, ornithine, creatinine, glycine, isoleucine and trimethylamine N‐oxide. The MetPA analysis revealed seven involved metabolic pathways: arginine and proline metabolism; taurine and hypotaurine metabolism; glycine, serine and threonine metabolism; glyoxylate and dicarboxylate metabolism; methane metabolism; citrate cycle; and pyruvate metabolism. The perturbed metabolic profiles suggest potential metabolic reprogramming associated with a combination treatment of inhaled budesonide and salbutamol in asthmatic children.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27730746</pmid><doi>10.1111/bcpt.12686</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1742-7835 |
| ispartof | Basic & clinical pharmacology & toxicology, 2017-03, Vol.120 (3), p.303-311 |
| issn | 1742-7835 1742-7843 |
| language | eng |
| recordid | cdi_proquest_journals_2438563340 |
| source | MEDLINE; Wiley Online Library Journals; Alma/SFX Local Collection |
| subjects | Administration, Inhalation Adrenergic beta-2 Receptor Agonists - administration & dosage Adrenergic beta-2 Receptor Agonists - pharmacokinetics Alanine Albuterol - administration & dosage Albuterol - pharmacokinetics Arginine Asparagine Asthma Asthma - blood Asthma - drug therapy Asthma - urine Bronchodilator Agents - administration & dosage Bronchodilator Agents - pharmacokinetics Budesonide Budesonide - administration & dosage Budesonide - pharmacokinetics Child Child, Preschool Children China Citric acid Citrulline Creatine Creatinine Disease Progression Drugs Glucocorticoids - administration & dosage Glucocorticoids - metabolism Glycerol Glycine Histamine Humans Infant Isoleucine Lactic acid Magnetic Resonance Spectroscopy Male Metabolic pathways Metabolism Metabolites Metabolome Metabolomics Metabolomics - methods Multivariate Analysis NMR Nuclear magnetic resonance Ornithine Phosphocholine Principal components analysis Proline Pyruvic acid Respiratory therapy Salbutamol Sarcosine Trimethylamine Urine |
| title | Distinct Metabolic Profile of Inhaled Budesonide and Salbutamol in Asthmatic Children during Acute Exacerbation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T16%3A08%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Distinct%20Metabolic%20Profile%20of%20Inhaled%20Budesonide%20and%20Salbutamol%20in%20Asthmatic%20Children%20during%20Acute%20Exacerbation&rft.jtitle=Basic%20&%20clinical%20pharmacology%20&%20toxicology&rft.au=Quan%E2%80%90Jun,%20Yang&rft.date=2017-03&rft.volume=120&rft.issue=3&rft.spage=303&rft.epage=311&rft.pages=303-311&rft.issn=1742-7835&rft.eissn=1742-7843&rft_id=info:doi/10.1111/bcpt.12686&rft_dat=%3Cproquest_cross%3E2438563340%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1866023374&rft_id=info:pmid/27730746&rfr_iscdi=true |