Soshiho-tang protects LPS-induced acute liver injury by attenuating inflammatory response
Soshiho-tang (SSHT) has traditionally been used to treat gastrointestinal disorders. In this experiment, we investigated the protective effect of SSHT on inflammatory liver injury in lipopolysaccharide (LPS)-sensitized mice. Male C57BL/6J mice aged 6 weeks were randomly placed in 6 groups ( n = 5):...
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| Veröffentlicht in: | Journal of natural medicines 2020-09, Vol.74 (4), p.788-795 |
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| creator | Jin, Seong Chul Kim, Mi Hye Jo, Si Yeon Yoon Choi, La Lee, Haesu Yang, Woong Mo |
| description | Soshiho-tang (SSHT) has traditionally been used to treat gastrointestinal disorders. In this experiment, we investigated the protective effect of SSHT on inflammatory liver injury in lipopolysaccharide (LPS)-sensitized mice. Male C57BL/6J mice aged 6 weeks were randomly placed in 6 groups (
n
= 5): normal mice (CTR), LPS-sensitized mice (LPS), LPS-sensitized mice treated with dexamethasone (DEX) and LPS-sensitized mice treated with 0.05, 0.55, and 5.55 g/kg of SSHT (SSHT 0.05, SSHT 0.55, and SSHT 5.55). Various doses of SSHT was given once a day for 7 days. After 2 h of LPS injection, the liver tissue was collected. SSHT pretreatment recovered hemorrhage of liver tissues in LPS-induced acute liver injury. The expressions of MAP Kinase, NF-κB, IκBα, p-IκBα, COX-2, and iNOS protein levels were markedly decreased by SSHT-treated liver tissues. Additionally, SSHT pretreatment significantly regulated the expressions of MCP-1, TNF-α, and IL-6 cytokines. These results suggest the potential of SSHT on the protection of acute liver injury. |
| doi_str_mv | 10.1007/s11418-020-01421-w |
| format | Article |
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n
= 5): normal mice (CTR), LPS-sensitized mice (LPS), LPS-sensitized mice treated with dexamethasone (DEX) and LPS-sensitized mice treated with 0.05, 0.55, and 5.55 g/kg of SSHT (SSHT 0.05, SSHT 0.55, and SSHT 5.55). Various doses of SSHT was given once a day for 7 days. After 2 h of LPS injection, the liver tissue was collected. SSHT pretreatment recovered hemorrhage of liver tissues in LPS-induced acute liver injury. The expressions of MAP Kinase, NF-κB, IκBα, p-IκBα, COX-2, and iNOS protein levels were markedly decreased by SSHT-treated liver tissues. Additionally, SSHT pretreatment significantly regulated the expressions of MCP-1, TNF-α, and IL-6 cytokines. These results suggest the potential of SSHT on the protection of acute liver injury.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-020-01421-w</identifier><identifier>PMID: 32533386</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Acute Disease ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Chemical and Drug Induced Liver Injury - drug therapy ; Complementary & Alternative Medicine ; Cyclooxygenase-2 ; Dexamethasone ; Gastrointestinal diseases ; Hemorrhage ; Humans ; Inflammation ; Inflammation - drug therapy ; Interleukin 6 ; Kinases ; Lipopolysaccharides ; Lipopolysaccharides - adverse effects ; Liver ; Liver - pathology ; Male ; MAP kinase ; Medicinal Chemistry ; Mice ; Mice, Inbred C57BL ; Monocyte chemoattractant protein 1 ; NF-κB protein ; Nitric-oxide synthase ; Pharmacology/Toxicology ; Pharmacy ; Plant Extracts - chemistry ; Plant Sciences ; Tumor necrosis factor-α</subject><ispartof>Journal of natural medicines, 2020-09, Vol.74 (4), p.788-795</ispartof><rights>The Japanese Society of Pharmacognosy 2020</rights><rights>The Japanese Society of Pharmacognosy 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-5b6d47708868da726d959325cf48e1af530a3d5bb1a127a8ed76d7122d0e6f553</citedby><cites>FETCH-LOGICAL-c426t-5b6d47708868da726d959325cf48e1af530a3d5bb1a127a8ed76d7122d0e6f553</cites><orcidid>0000-0001-5308-2386</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-020-01421-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-020-01421-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32533386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, Seong Chul</creatorcontrib><creatorcontrib>Kim, Mi Hye</creatorcontrib><creatorcontrib>Jo, Si Yeon</creatorcontrib><creatorcontrib>Yoon Choi, La</creatorcontrib><creatorcontrib>Lee, Haesu</creatorcontrib><creatorcontrib>Yang, Woong Mo</creatorcontrib><title>Soshiho-tang protects LPS-induced acute liver injury by attenuating inflammatory response</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>Soshiho-tang (SSHT) has traditionally been used to treat gastrointestinal disorders. In this experiment, we investigated the protective effect of SSHT on inflammatory liver injury in lipopolysaccharide (LPS)-sensitized mice. Male C57BL/6J mice aged 6 weeks were randomly placed in 6 groups (
n
= 5): normal mice (CTR), LPS-sensitized mice (LPS), LPS-sensitized mice treated with dexamethasone (DEX) and LPS-sensitized mice treated with 0.05, 0.55, and 5.55 g/kg of SSHT (SSHT 0.05, SSHT 0.55, and SSHT 5.55). Various doses of SSHT was given once a day for 7 days. After 2 h of LPS injection, the liver tissue was collected. SSHT pretreatment recovered hemorrhage of liver tissues in LPS-induced acute liver injury. The expressions of MAP Kinase, NF-κB, IκBα, p-IκBα, COX-2, and iNOS protein levels were markedly decreased by SSHT-treated liver tissues. Additionally, SSHT pretreatment significantly regulated the expressions of MCP-1, TNF-α, and IL-6 cytokines. These results suggest the potential of SSHT on the protection of acute liver injury.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Chemical and Drug Induced Liver Injury - drug therapy</subject><subject>Complementary & Alternative Medicine</subject><subject>Cyclooxygenase-2</subject><subject>Dexamethasone</subject><subject>Gastrointestinal diseases</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Interleukin 6</subject><subject>Kinases</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - adverse effects</subject><subject>Liver</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>MAP kinase</subject><subject>Medicinal Chemistry</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Monocyte chemoattractant protein 1</subject><subject>NF-κB protein</subject><subject>Nitric-oxide synthase</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Sciences</subject><subject>Tumor necrosis factor-α</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAyxQJNYGv-0sUcVLqgRSYcHKcmKnTdUkxXao-vcYUmDHakYz994ZHQDOMbrCCMnrgDHDCiKCIMKMYLg9AGOsBE6jnB6mnjIEKWN0BE5CWCHECKX4GIwo4ZRSJcbgbd6FZb3sYDTtItv4Lroyhmz2PId1a_vS2cyUfXTZuv5wPqvbVe93WbHLTIyu7U2sk61uq7VpGhO7tPMubLo2uFNwVJl1cGf7OgGvd7cv0wc4e7p_nN7MYMmIiJAXwjIpkVJCWSOJsDnP039lxZTDpuIUGWp5UWCDiTTKWSmsxIRY5ETFOZ2AyyE3Pf_euxD1qut9m05qwqiiOedCJhUZVKXvQvCu0htfN8bvNEb6i6YeaOpEU3_T1NtkuthH90Xj7K_lB18S0EEQ0qpdOP93-5_YT3FJgMw</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Jin, Seong Chul</creator><creator>Kim, Mi Hye</creator><creator>Jo, Si Yeon</creator><creator>Yoon Choi, La</creator><creator>Lee, Haesu</creator><creator>Yang, Woong Mo</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0001-5308-2386</orcidid></search><sort><creationdate>20200901</creationdate><title>Soshiho-tang protects LPS-induced acute liver injury by attenuating inflammatory response</title><author>Jin, Seong Chul ; Kim, Mi Hye ; Jo, Si Yeon ; Yoon Choi, La ; Lee, Haesu ; Yang, Woong Mo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-5b6d47708868da726d959325cf48e1af530a3d5bb1a127a8ed76d7122d0e6f553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Chemical and Drug Induced Liver Injury - drug therapy</topic><topic>Complementary & Alternative Medicine</topic><topic>Cyclooxygenase-2</topic><topic>Dexamethasone</topic><topic>Gastrointestinal diseases</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Interleukin 6</topic><topic>Kinases</topic><topic>Lipopolysaccharides</topic><topic>Lipopolysaccharides - adverse effects</topic><topic>Liver</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>MAP kinase</topic><topic>Medicinal Chemistry</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Monocyte chemoattractant protein 1</topic><topic>NF-κB protein</topic><topic>Nitric-oxide synthase</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Sciences</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Seong Chul</creatorcontrib><creatorcontrib>Kim, Mi Hye</creatorcontrib><creatorcontrib>Jo, Si Yeon</creatorcontrib><creatorcontrib>Yoon Choi, La</creatorcontrib><creatorcontrib>Lee, Haesu</creatorcontrib><creatorcontrib>Yang, Woong Mo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Seong Chul</au><au>Kim, Mi Hye</au><au>Jo, Si Yeon</au><au>Yoon Choi, La</au><au>Lee, Haesu</au><au>Yang, Woong Mo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soshiho-tang protects LPS-induced acute liver injury by attenuating inflammatory response</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>74</volume><issue>4</issue><spage>788</spage><epage>795</epage><pages>788-795</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>Soshiho-tang (SSHT) has traditionally been used to treat gastrointestinal disorders. In this experiment, we investigated the protective effect of SSHT on inflammatory liver injury in lipopolysaccharide (LPS)-sensitized mice. Male C57BL/6J mice aged 6 weeks were randomly placed in 6 groups (
n
= 5): normal mice (CTR), LPS-sensitized mice (LPS), LPS-sensitized mice treated with dexamethasone (DEX) and LPS-sensitized mice treated with 0.05, 0.55, and 5.55 g/kg of SSHT (SSHT 0.05, SSHT 0.55, and SSHT 5.55). Various doses of SSHT was given once a day for 7 days. After 2 h of LPS injection, the liver tissue was collected. SSHT pretreatment recovered hemorrhage of liver tissues in LPS-induced acute liver injury. The expressions of MAP Kinase, NF-κB, IκBα, p-IκBα, COX-2, and iNOS protein levels were markedly decreased by SSHT-treated liver tissues. Additionally, SSHT pretreatment significantly regulated the expressions of MCP-1, TNF-α, and IL-6 cytokines. These results suggest the potential of SSHT on the protection of acute liver injury.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>32533386</pmid><doi>10.1007/s11418-020-01421-w</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5308-2386</orcidid></addata></record> |
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| subjects | Acute Disease Animals Biomedical and Life Sciences Biomedicine Chemical and Drug Induced Liver Injury - drug therapy Complementary & Alternative Medicine Cyclooxygenase-2 Dexamethasone Gastrointestinal diseases Hemorrhage Humans Inflammation Inflammation - drug therapy Interleukin 6 Kinases Lipopolysaccharides Lipopolysaccharides - adverse effects Liver Liver - pathology Male MAP kinase Medicinal Chemistry Mice Mice, Inbred C57BL Monocyte chemoattractant protein 1 NF-κB protein Nitric-oxide synthase Pharmacology/Toxicology Pharmacy Plant Extracts - chemistry Plant Sciences Tumor necrosis factor-α |
| title | Soshiho-tang protects LPS-induced acute liver injury by attenuating inflammatory response |
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