Anti-proliferative and anti-migratory effects of flower-like bimetallic (Au@Pt) nanoparticles

[Display omitted] •Flower-like bimetallic (Au@Pt) nanoparticles were synthesized using Carica papaya leaf extract.•Optical, structural, and functional properties of the bimetallic nanoparticles were reported.•Bimetallic nanoparticles exhibit anti-proliferative and anti-migration effects against brea...

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Veröffentlicht in:Materials letters 2020-05, Vol.267, p.127491, Article 127491
Hauptverfasser: Princely, Sebastian Xavier, Puja, Patel, Vinita, Manimaran Nadar, Devan, Umapathy, Velangani, Antony Joseph, Sunita, Sinha, Yuvakkumar, Rathinam, Velmurugan, Palanivelu, Ravi, Arumugam Veera, Govarthanan, Muthusamy, Kumar, Ponnuchamy
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container_start_page 127491
container_title Materials letters
container_volume 267
creator Princely, Sebastian Xavier
Puja, Patel
Vinita, Manimaran Nadar
Devan, Umapathy
Velangani, Antony Joseph
Sunita, Sinha
Yuvakkumar, Rathinam
Velmurugan, Palanivelu
Ravi, Arumugam Veera
Govarthanan, Muthusamy
Kumar, Ponnuchamy
description [Display omitted] •Flower-like bimetallic (Au@Pt) nanoparticles were synthesized using Carica papaya leaf extract.•Optical, structural, and functional properties of the bimetallic nanoparticles were reported.•Bimetallic nanoparticles exhibit anti-proliferative and anti-migration effects against breast cancer cells. In this work, flower-like bimetallic (Au@Pt) nanoparticles were synthesized by using Carica papaya leaf extract. The optical, structural, and functional properties have been investigated. The UV–vis spectra inferred the formation of bimetallic nanoparticles with highly ordered crystalline structure as revealed by X-ray diffraction analysis. The TEM micrography revealed flower-like bimetallic nanoparticles of 150 ± 1.02 nm. The cytotoxicity of bimetallic nanoparticles was confirmed against MCF-7 breast cancer cells, which indicates their anti-proliferative effect (IC50 value − 120 ± 2.32 µg mL−1). The developed flower-like bimetallic nanoparticles also displayed anti-migration effect by wound healing assay, making it sensibly valuable for cancer chemotherapy.
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subjects Anti-migration effect
Antiproliferatives
Bimetals
Biomaterials
Cancer
Functional
Materials science
Nanoparticles
Optical properties
Platinum
Structural
Toxicity
Wound healing
title Anti-proliferative and anti-migratory effects of flower-like bimetallic (Au@Pt) nanoparticles
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