Influence of screw configuration and processing parameters on the dissolution of ketoprofen in polymer blends

The solubility and dissolution enhancement of the poorly soluble drug ketoprofen (KTO) in polymer blends prepared by hot melt extrusion was studied using two different screw configurations while changing extrusion processing conditions. A number of different Soluplus and Kollidon SR blends were used...

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Veröffentlicht in:	Journal of applied polymer science 2020-12, Vol.137 (45), p.n/a
Hauptverfasser:	Restrepo‐Uribe, Laura, Ioannidis, Nicolas, Noriega Escobar, María del Pilar
Format:	Artikel
Sprache:	eng
Schlagworte:	Configurations Design of experiments Differential scanning calorimetry Dissolution Drug delivery systems Extrusion Heat measurement Hydrogen bonds Ketoprofen Light diffraction Materials science NMR Nuclear magnetic resonance Optical microscopy Polarized light Polymer blends Polymers Process parameters Solid solutions Van der Waals forces X-ray diffraction
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