Recent Progress on Relevant microRNAs in Autism Spectrum Disorders
Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathogenesis is unclear and is affected by both genetic and environmental factors. The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-tra...
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| Veröffentlicht in: | International journal of molecular sciences 2020-08, Vol.21 (16), p.5904 |
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| description | Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathogenesis is unclear and is affected by both genetic and environmental factors. The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-transcriptional level. miRNAs are involved in almost all biological processes and are closely related to ASD and many other diseases. In this review, we summarize relevant miRNAs in ASD, and analyze dysregulated miRNAs in brain tissues and body fluids of ASD patients, which may contribute to the pathogenesis and diagnosis of ASD. |
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The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-transcriptional level. miRNAs are involved in almost all biological processes and are closely related to ASD and many other diseases. In this review, we summarize relevant miRNAs in ASD, and analyze dysregulated miRNAs in brain tissues and body fluids of ASD patients, which may contribute to the pathogenesis and diagnosis of ASD.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21165904</identifier><identifier>PMID: 32824515</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animal cognition ; Animals ; Autism ; autism spectrum disorder (ASD) ; Autism Spectrum Disorder - blood ; Autism Spectrum Disorder - diagnosis ; Autism Spectrum Disorder - genetics ; Behavior ; Binding sites ; Biological activity ; Biomarkers ; Biomarkers - blood ; Biomarkers - metabolism ; Body fluids ; Brain - metabolism ; Brain research ; Brain-derived neurotrophic factor ; Circadian rhythm ; Circulating MicroRNA - blood ; Circulating MicroRNA - genetics ; Circulating MicroRNA - metabolism ; Dermatitis ; Fatty acids ; Gene expression ; Humans ; Kinases ; Metabolism ; MicroRNAs ; miRNA ; miRNA target ; Mutation ; Nervous system ; Neurodevelopmental disorders ; Non-coding RNA ; Nucleotides ; Pathogenesis ; Post-transcription ; Proteins ; Review ; Roles ; Saliva - metabolism ; Society ; therapy</subject><ispartof>International journal of molecular sciences, 2020-08, Vol.21 (16), p.5904</ispartof><rights>2020. 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The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-transcriptional level. miRNAs are involved in almost all biological processes and are closely related to ASD and many other diseases. In this review, we summarize relevant miRNAs in ASD, and analyze dysregulated miRNAs in brain tissues and body fluids of ASD patients, which may contribute to the pathogenesis and diagnosis of ASD.</description><subject>Animal cognition</subject><subject>Animals</subject><subject>Autism</subject><subject>autism spectrum disorder (ASD)</subject><subject>Autism Spectrum Disorder - blood</subject><subject>Autism Spectrum Disorder - diagnosis</subject><subject>Autism Spectrum Disorder - genetics</subject><subject>Behavior</subject><subject>Binding sites</subject><subject>Biological activity</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - metabolism</subject><subject>Body fluids</subject><subject>Brain - metabolism</subject><subject>Brain research</subject><subject>Brain-derived neurotrophic factor</subject><subject>Circadian rhythm</subject><subject>Circulating MicroRNA - blood</subject><subject>Circulating MicroRNA - genetics</subject><subject>Circulating MicroRNA - metabolism</subject><subject>Dermatitis</subject><subject>Fatty acids</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Kinases</subject><subject>Metabolism</subject><subject>MicroRNAs</subject><subject>miRNA</subject><subject>miRNA target</subject><subject>Mutation</subject><subject>Nervous system</subject><subject>Neurodevelopmental disorders</subject><subject>Non-coding RNA</subject><subject>Nucleotides</subject><subject>Pathogenesis</subject><subject>Post-transcription</subject><subject>Proteins</subject><subject>Review</subject><subject>Roles</subject><subject>Saliva - metabolism</subject><subject>Society</subject><subject>therapy</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>DOA</sourceid><recordid>eNpdkUtv1DAURi0EomVgxxpFYsOCobavnxukoTxaqQI0wNpynJvBoySe2kkl_j1pp62mXdm6Pjry_T5CXjP6AcDSk7jtC2dMSUvFE3LMBOdLSpV-enA_Ii9K2VLKgUv7nBwBN1xIJo_JpzUGHMbqZ06bjKVUaajW2OGVn4d9DDmtv69KFYdqNY2x9NWvHYYxT331OZaUG8zlJXnW-q7gq9tzQf58_fL79Gx58ePb-enqYhmENuOSS4-aAaC3tZVcA4a2YVpKBoJyrrikrQhee6-4NlAbFTTTrfGS1ga0hQU533ub5Ldul2Pv8z-XfHQ3g5Q3zucxhg6dbQDqulFMeiUMNkY1tEWmRA2BWY2z6-PetZvqHpvrCLLvHkgfvgzxr9ukK6eFotKIWfDuVpDT5YRldH0sAbvOD5im4rgABZbZOfIFefsI3aYpD3NUNxRnhgqYqfd7ao68lIzt_WcYdddFu8OiZ_zN4QL38F2z8B9L-KKG</recordid><startdate>20200817</startdate><enddate>20200817</enddate><creator>Wu, Xingwang</creator><creator>Li, Wanran</creator><creator>Zheng, Yun</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4292-9806</orcidid></search><sort><creationdate>20200817</creationdate><title>Recent Progress on Relevant microRNAs in Autism Spectrum Disorders</title><author>Wu, Xingwang ; Li, Wanran ; Zheng, Yun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-25ae7133ea9b95273ecfd17551340226250f4ca7aa62783b86c717f8a50b83793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animal cognition</topic><topic>Animals</topic><topic>Autism</topic><topic>autism spectrum disorder (ASD)</topic><topic>Autism Spectrum Disorder - blood</topic><topic>Autism Spectrum Disorder - diagnosis</topic><topic>Autism Spectrum Disorder - genetics</topic><topic>Behavior</topic><topic>Binding sites</topic><topic>Biological activity</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - metabolism</topic><topic>Body fluids</topic><topic>Brain - metabolism</topic><topic>Brain research</topic><topic>Brain-derived neurotrophic factor</topic><topic>Circadian rhythm</topic><topic>Circulating MicroRNA - blood</topic><topic>Circulating MicroRNA - genetics</topic><topic>Circulating MicroRNA - metabolism</topic><topic>Dermatitis</topic><topic>Fatty acids</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Kinases</topic><topic>Metabolism</topic><topic>MicroRNAs</topic><topic>miRNA</topic><topic>miRNA target</topic><topic>Mutation</topic><topic>Nervous system</topic><topic>Neurodevelopmental disorders</topic><topic>Non-coding RNA</topic><topic>Nucleotides</topic><topic>Pathogenesis</topic><topic>Post-transcription</topic><topic>Proteins</topic><topic>Review</topic><topic>Roles</topic><topic>Saliva - metabolism</topic><topic>Society</topic><topic>therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Xingwang</creatorcontrib><creatorcontrib>Li, Wanran</creatorcontrib><creatorcontrib>Zheng, Yun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Xingwang</au><au>Li, Wanran</au><au>Zheng, Yun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent Progress on Relevant microRNAs in Autism Spectrum Disorders</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-08-17</date><risdate>2020</risdate><volume>21</volume><issue>16</issue><spage>5904</spage><pages>5904-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose pathogenesis is unclear and is affected by both genetic and environmental factors. The microRNAs (miRNAs) are a kind of single-stranded non-coding RNA with 20-22 nucleotides, which normally inhibit their target mRNAs at a post-transcriptional level. miRNAs are involved in almost all biological processes and are closely related to ASD and many other diseases. In this review, we summarize relevant miRNAs in ASD, and analyze dysregulated miRNAs in brain tissues and body fluids of ASD patients, which may contribute to the pathogenesis and diagnosis of ASD.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32824515</pmid><doi>10.3390/ijms21165904</doi><orcidid>https://orcid.org/0000-0003-4292-9806</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animal cognition Animals Autism autism spectrum disorder (ASD) Autism Spectrum Disorder - blood Autism Spectrum Disorder - diagnosis Autism Spectrum Disorder - genetics Behavior Binding sites Biological activity Biomarkers Biomarkers - blood Biomarkers - metabolism Body fluids Brain - metabolism Brain research Brain-derived neurotrophic factor Circadian rhythm Circulating MicroRNA - blood Circulating MicroRNA - genetics Circulating MicroRNA - metabolism Dermatitis Fatty acids Gene expression Humans Kinases Metabolism MicroRNAs miRNA miRNA target Mutation Nervous system Neurodevelopmental disorders Non-coding RNA Nucleotides Pathogenesis Post-transcription Proteins Review Roles Saliva - metabolism Society therapy |
| title | Recent Progress on Relevant microRNAs in Autism Spectrum Disorders |
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