Bio-redox potential of Hyphaene thebaica in bio-fabrication of ultrafine maghemite phase iron oxide nanoparticles (Fe2O3 NPs) for therapeutic applications
Maghemite (Fe2O3-NPs) nanoparticles were synthesized by a convenient, green and cost effective method using aqueous fruit extracts of Hyphaene thebaica. Different techniques like FTIR, XRD, UV–Vis, Raman, HR-TEM, EDS. SAED, Zeta potential were used to establish the nature of Fe2O3-NPs, while the the...
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| description | Maghemite (Fe2O3-NPs) nanoparticles were synthesized by a convenient, green and cost effective method using aqueous fruit extracts of Hyphaene thebaica. Different techniques like FTIR, XRD, UV–Vis, Raman, HR-TEM, EDS. SAED, Zeta potential were used to establish the nature of Fe2O3-NPs, while the therapeutic properties were studied using different biological assays including antiviral, antibacterial, antifungal, antioxidant and enzyme inhibition assays. XRD pattern revealed sharp peaks and a crystalline nature of Fe2O3-NPs. HR-TEM revealed quasi-spherical and cuboidal morphologies, while the particle size in ~10 nm. FTIR indicated a sharp peak centered at ~444 cm−1 which is the characteristic FeO band vibration. SAED pattern indicated the crystalline nature while EDS also confirmed the synthesis of Fe2O3 NPs. Zeta potential was obtained in different solvents and physiological buffers indicating highest value in water (−26.5 mV) and lowest in DMSO (−15.8 mV). Tested bacterial strains, Bacillus subtilis was found to be inhibited significantly. Aspergillus flavus appeared to be susceptible to all of the tested concentration of Fe2O3 NPs. Maximum 40.78% FRSA was obtained at 400 μg/mL. Cell culture based studies on RD cells and L20B cells indicated reduction in viability of cells with increase concentration of Fe2O3 NPs. Moderate inhibition of polio virus-1 and polio virus-2 was observed, after culturing the virus in the L20B cells. Excellent Protein Kinase (PK) inhibition was revealed. Hemolytic potential and cytotoxic potential was indicated to be dose dependent. In conclusion, the present report for the first time reports the synthesis of Fe2O3 NPs from H. thebaica fruits and reveals their biomedical potential including antiviral potential.
•Fe2O3-NPs were synthesized using Hyphaene thebaica as a bioreducing agents•The room temperature physical properties were established using diverse techniques•Diverse in vitro assays revealed promising therapeutic potential of Fe2O3-NPs•The antiviral assay revealed tendency of the Fe2O3-NPs to inhibit the polio virus.•Promising antimicrobial, antioxidant and enzyme inhibition potential is reported for Fe2O3-NPs |
| doi_str_mv | 10.1016/j.msec.2020.110890 |
| format | Article |
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•Fe2O3-NPs were synthesized using Hyphaene thebaica as a bioreducing agents•The room temperature physical properties were established using diverse techniques•Diverse in vitro assays revealed promising therapeutic potential of Fe2O3-NPs•The antiviral assay revealed tendency of the Fe2O3-NPs to inhibit the polio virus.•Promising antimicrobial, antioxidant and enzyme inhibition potential is reported for Fe2O3-NPs</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2020.110890</identifier><identifier>PMID: 32409045</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antifungal Agents - chemical synthesis ; Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Antimicrobial ; Antioxidant ; Antioxidants ; Antiviral ; Antiviral Agents - chemical synthesis ; Antiviral Agents - chemistry ; Antiviral Agents - pharmacology ; Arecaceae - chemistry ; Arecaceae - metabolism ; Aspergillus flavus - drug effects ; Bacillus subtilis - drug effects ; Cell culture ; Cell Line ; Cell Survival - drug effects ; Crystal structure ; Crystallinity ; Cytotoxicity ; Enzyme inhibition ; Fabrication ; Fe2O3 nanoparticles ; Ferric oxide ; Fruit - chemistry ; Fruit - metabolism ; Fruits ; Fungicides ; Green Chemistry Technology ; Hemolysis - drug effects ; Humans ; Hyphaene thebaica ; Iron oxides ; Kinases ; Magnetic Iron Oxide Nanoparticles - chemistry ; Magnetic Iron Oxide Nanoparticles - toxicity ; Materials science ; Morphology ; Nanoparticles ; Oxidation-Reduction ; Particle Size ; Plant Extracts - chemistry ; Poliomyelitis ; Poliovirus - drug effects ; Poliovirus - physiology ; Protein kinase ; Redox potential ; Synthesis ; Therapeutic applications ; Ultrafines ; Vibration ; Viruses ; Zeta potential</subject><ispartof>Materials Science & Engineering C, 2020-07, Vol.112, p.110890, Article 110890</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Jul 2020</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-975685677f0a7d2483dbf5be8284e166efc8df3ace14735292fecbe7276a0d263</citedby><cites>FETCH-LOGICAL-c384t-975685677f0a7d2483dbf5be8284e166efc8df3ace14735292fecbe7276a0d263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0928493120302988$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32409045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohamed, Hamza Elsayed Ahmed</creatorcontrib><creatorcontrib>Afridi, Shakeeb</creatorcontrib><creatorcontrib>Khalil, Ali Talha</creatorcontrib><creatorcontrib>Ali, Muhammad</creatorcontrib><creatorcontrib>Zohra, Tanzeel</creatorcontrib><creatorcontrib>Salman, Muhammad</creatorcontrib><creatorcontrib>Ikram, Aamer</creatorcontrib><creatorcontrib>Shinwari, Zabta Khan</creatorcontrib><creatorcontrib>Maaza, Malik</creatorcontrib><title>Bio-redox potential of Hyphaene thebaica in bio-fabrication of ultrafine maghemite phase iron oxide nanoparticles (Fe2O3 NPs) for therapeutic applications</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>Maghemite (Fe2O3-NPs) nanoparticles were synthesized by a convenient, green and cost effective method using aqueous fruit extracts of Hyphaene thebaica. Different techniques like FTIR, XRD, UV–Vis, Raman, HR-TEM, EDS. SAED, Zeta potential were used to establish the nature of Fe2O3-NPs, while the therapeutic properties were studied using different biological assays including antiviral, antibacterial, antifungal, antioxidant and enzyme inhibition assays. XRD pattern revealed sharp peaks and a crystalline nature of Fe2O3-NPs. HR-TEM revealed quasi-spherical and cuboidal morphologies, while the particle size in ~10 nm. FTIR indicated a sharp peak centered at ~444 cm−1 which is the characteristic FeO band vibration. SAED pattern indicated the crystalline nature while EDS also confirmed the synthesis of Fe2O3 NPs. Zeta potential was obtained in different solvents and physiological buffers indicating highest value in water (−26.5 mV) and lowest in DMSO (−15.8 mV). Tested bacterial strains, Bacillus subtilis was found to be inhibited significantly. Aspergillus flavus appeared to be susceptible to all of the tested concentration of Fe2O3 NPs. Maximum 40.78% FRSA was obtained at 400 μg/mL. Cell culture based studies on RD cells and L20B cells indicated reduction in viability of cells with increase concentration of Fe2O3 NPs. Moderate inhibition of polio virus-1 and polio virus-2 was observed, after culturing the virus in the L20B cells. Excellent Protein Kinase (PK) inhibition was revealed. Hemolytic potential and cytotoxic potential was indicated to be dose dependent. In conclusion, the present report for the first time reports the synthesis of Fe2O3 NPs from H. thebaica fruits and reveals their biomedical potential including antiviral potential.
•Fe2O3-NPs were synthesized using Hyphaene thebaica as a bioreducing agents•The room temperature physical properties were established using diverse techniques•Diverse in vitro assays revealed promising therapeutic potential of Fe2O3-NPs•The antiviral assay revealed tendency of the Fe2O3-NPs to inhibit the polio virus.•Promising antimicrobial, antioxidant and enzyme inhibition potential is reported for Fe2O3-NPs</description><subject>Animals</subject><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antifungal Agents - chemical synthesis</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antimicrobial</subject><subject>Antioxidant</subject><subject>Antioxidants</subject><subject>Antiviral</subject><subject>Antiviral Agents - chemical synthesis</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - 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chemistry</subject><subject>Poliomyelitis</subject><subject>Poliovirus - drug effects</subject><subject>Poliovirus - physiology</subject><subject>Protein kinase</subject><subject>Redox potential</subject><subject>Synthesis</subject><subject>Therapeutic applications</subject><subject>Ultrafines</subject><subject>Vibration</subject><subject>Viruses</subject><subject>Zeta potential</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EotPSF2CBLLGBRab-S-xIbEpFW6SKsqBry3GuGY-SONgOal-lT4ujGViysuz7nXN0fRB6S8mWEtpc7LdjArtlhJUHSlRLXqANVZJXhLb0JdqQlqlKtJyeoNOU9oQ0ikv2Gp1wJkhLRL1Bz599qCL04RHPIcOUvRlwcPj2ad4ZmADnHXTGW4P9hLvCOtPFcs0-TCu3DDka5ws4mp87GH0GXJQJsI8r8eh7wJOZwmxi9naAhD9cA7vn-Nv39BG7ENeEaGZYyhibeR6O7ukNeuXMkOD8eJ6hh-svP65uq7v7m69Xl3eV5UrkqpV1o-pGSkeM7JlQvO9c3YFiSgBtGnBW9Y4bC1RIXrOWObAdSCYbQ3rW8DP0_uA7x_BrgZT1PixxKpGaCV4rwQSVhWIHysaQUgSn5-hHE580JXqtQ-_1Wode69CHOoro3dF66Ubo_0n-_n8BPh0AKAv-9hB1sh4mC72PYLPug_-f_x9QTJ16</recordid><startdate>202007</startdate><enddate>202007</enddate><creator>Mohamed, Hamza Elsayed Ahmed</creator><creator>Afridi, Shakeeb</creator><creator>Khalil, Ali Talha</creator><creator>Ali, Muhammad</creator><creator>Zohra, Tanzeel</creator><creator>Salman, Muhammad</creator><creator>Ikram, Aamer</creator><creator>Shinwari, Zabta Khan</creator><creator>Maaza, Malik</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope></search><sort><creationdate>202007</creationdate><title>Bio-redox potential of Hyphaene thebaica in bio-fabrication of ultrafine maghemite phase iron oxide nanoparticles (Fe2O3 NPs) for therapeutic applications</title><author>Mohamed, Hamza Elsayed Ahmed ; Afridi, Shakeeb ; Khalil, Ali Talha ; Ali, Muhammad ; Zohra, Tanzeel ; Salman, Muhammad ; Ikram, Aamer ; Shinwari, Zabta Khan ; Maaza, Malik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-975685677f0a7d2483dbf5be8284e166efc8df3ace14735292fecbe7276a0d263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - 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metabolism</topic><topic>Fruits</topic><topic>Fungicides</topic><topic>Green Chemistry Technology</topic><topic>Hemolysis - drug effects</topic><topic>Humans</topic><topic>Hyphaene thebaica</topic><topic>Iron oxides</topic><topic>Kinases</topic><topic>Magnetic Iron Oxide Nanoparticles - chemistry</topic><topic>Magnetic Iron Oxide Nanoparticles - toxicity</topic><topic>Materials science</topic><topic>Morphology</topic><topic>Nanoparticles</topic><topic>Oxidation-Reduction</topic><topic>Particle Size</topic><topic>Plant Extracts - chemistry</topic><topic>Poliomyelitis</topic><topic>Poliovirus - drug effects</topic><topic>Poliovirus - physiology</topic><topic>Protein kinase</topic><topic>Redox potential</topic><topic>Synthesis</topic><topic>Therapeutic applications</topic><topic>Ultrafines</topic><topic>Vibration</topic><topic>Viruses</topic><topic>Zeta potential</topic><toplevel>online_resources</toplevel><creatorcontrib>Mohamed, Hamza Elsayed Ahmed</creatorcontrib><creatorcontrib>Afridi, Shakeeb</creatorcontrib><creatorcontrib>Khalil, Ali Talha</creatorcontrib><creatorcontrib>Ali, Muhammad</creatorcontrib><creatorcontrib>Zohra, Tanzeel</creatorcontrib><creatorcontrib>Salman, Muhammad</creatorcontrib><creatorcontrib>Ikram, Aamer</creatorcontrib><creatorcontrib>Shinwari, Zabta Khan</creatorcontrib><creatorcontrib>Maaza, Malik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohamed, Hamza Elsayed Ahmed</au><au>Afridi, Shakeeb</au><au>Khalil, Ali Talha</au><au>Ali, Muhammad</au><au>Zohra, Tanzeel</au><au>Salman, Muhammad</au><au>Ikram, Aamer</au><au>Shinwari, Zabta Khan</au><au>Maaza, Malik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bio-redox potential of Hyphaene thebaica in bio-fabrication of ultrafine maghemite phase iron oxide nanoparticles (Fe2O3 NPs) for therapeutic applications</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2020-07</date><risdate>2020</risdate><volume>112</volume><spage>110890</spage><pages>110890-</pages><artnum>110890</artnum><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>Maghemite (Fe2O3-NPs) nanoparticles were synthesized by a convenient, green and cost effective method using aqueous fruit extracts of Hyphaene thebaica. Different techniques like FTIR, XRD, UV–Vis, Raman, HR-TEM, EDS. SAED, Zeta potential were used to establish the nature of Fe2O3-NPs, while the therapeutic properties were studied using different biological assays including antiviral, antibacterial, antifungal, antioxidant and enzyme inhibition assays. XRD pattern revealed sharp peaks and a crystalline nature of Fe2O3-NPs. HR-TEM revealed quasi-spherical and cuboidal morphologies, while the particle size in ~10 nm. FTIR indicated a sharp peak centered at ~444 cm−1 which is the characteristic FeO band vibration. SAED pattern indicated the crystalline nature while EDS also confirmed the synthesis of Fe2O3 NPs. Zeta potential was obtained in different solvents and physiological buffers indicating highest value in water (−26.5 mV) and lowest in DMSO (−15.8 mV). Tested bacterial strains, Bacillus subtilis was found to be inhibited significantly. Aspergillus flavus appeared to be susceptible to all of the tested concentration of Fe2O3 NPs. Maximum 40.78% FRSA was obtained at 400 μg/mL. Cell culture based studies on RD cells and L20B cells indicated reduction in viability of cells with increase concentration of Fe2O3 NPs. Moderate inhibition of polio virus-1 and polio virus-2 was observed, after culturing the virus in the L20B cells. Excellent Protein Kinase (PK) inhibition was revealed. Hemolytic potential and cytotoxic potential was indicated to be dose dependent. In conclusion, the present report for the first time reports the synthesis of Fe2O3 NPs from H. thebaica fruits and reveals their biomedical potential including antiviral potential.
•Fe2O3-NPs were synthesized using Hyphaene thebaica as a bioreducing agents•The room temperature physical properties were established using diverse techniques•Diverse in vitro assays revealed promising therapeutic potential of Fe2O3-NPs•The antiviral assay revealed tendency of the Fe2O3-NPs to inhibit the polio virus.•Promising antimicrobial, antioxidant and enzyme inhibition potential is reported for Fe2O3-NPs</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32409045</pmid><doi>10.1016/j.msec.2020.110890</doi></addata></record> |
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| subjects | Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antimicrobial Antioxidant Antioxidants Antiviral Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Arecaceae - chemistry Arecaceae - metabolism Aspergillus flavus - drug effects Bacillus subtilis - drug effects Cell culture Cell Line Cell Survival - drug effects Crystal structure Crystallinity Cytotoxicity Enzyme inhibition Fabrication Fe2O3 nanoparticles Ferric oxide Fruit - chemistry Fruit - metabolism Fruits Fungicides Green Chemistry Technology Hemolysis - drug effects Humans Hyphaene thebaica Iron oxides Kinases Magnetic Iron Oxide Nanoparticles - chemistry Magnetic Iron Oxide Nanoparticles - toxicity Materials science Morphology Nanoparticles Oxidation-Reduction Particle Size Plant Extracts - chemistry Poliomyelitis Poliovirus - drug effects Poliovirus - physiology Protein kinase Redox potential Synthesis Therapeutic applications Ultrafines Vibration Viruses Zeta potential |
| title | Bio-redox potential of Hyphaene thebaica in bio-fabrication of ultrafine maghemite phase iron oxide nanoparticles (Fe2O3 NPs) for therapeutic applications |
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