Hybridization Liquid Chromatography–Tandem Mass Spectrometry: An Alternative Bioanalytical Method for Antisense Oligonucleotide Quantitation in Plasma and Tissue Samples

Quantitative bioanalysis in plasma and tissues samples is required to study the pharmacokinetic and pharmacodynamic properties of antisense oligonucleotides (ASOs). To overcome intrinsic drawbacks in specificity, sensitivity, and throughput of traditional ligand-binding assay (LBA) and liquid chroma...

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Veröffentlicht in:	Analytical chemistry (Washington) 2020-08, Vol.92 (15), p.10548-10559
Hauptverfasser:	Li, Pei, Gong, Yuqing, Kim, Jaeah, Liu, Xingrong, Gilbert, James, Kerns, Hannah M, Groth, Rachel, Rooney, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Antisense oligonucleotides Automation Beads Biological properties Biological samples Calibration Chemistry Chromatography Chromatography, Liquid - methods Female Hybridization Infusions, Intraventricular Liquid chromatography Male Mass spectrometry Mass spectroscopy Metabolites Mice Mice, Inbred C57BL Oligonucleotides Oligonucleotides, Antisense - administration & dosage Oligonucleotides, Antisense - blood Oligonucleotides, Antisense - chemistry Oligonucleotides, Antisense - pharmacokinetics Pharmacodynamics Pharmacokinetics Pharmacology Plasma Quantitation Scientific imaging Sensitivity Sensitivity and Specificity Spectroscopy Streptavidin Tandem Mass Spectrometry Tissues
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