Combinatory Data-Independent Acquisition and Parallel Reaction Monitoring Method for Deep Profiling of Gangliosides

Ganglioside is an important class of lipid species involved in intercellular signaling and various diseases, especially for neurodegenerative diseases. Systematic ganglioside profiling is challenging because of their naturally low abundance and highly diverse species. Herein, a new data-independent...

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Veröffentlicht in:	Analytical chemistry (Washington) 2020-08, Vol.92 (15), p.10830-10838
Hauptverfasser:	Li, Hua, Xu, Ruilian, Yang, Lijun, Luan, Hemi, Chen, Shili, Chen, Lan, Cai, Zongwei, Tian, Ruijun
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytic Sample Preparation Methods Animals Biological properties Biological samples Brain - metabolism Ceramide Chemistry Colon Colon cancer Colonic Neoplasms - metabolism Depth profiling Gangliosides Gangliosides - blood Gangliosides - metabolism HeLa Cells Humans Ions Lipidomics - methods Lipids Mice Monitoring Neurodegenerative diseases New records Rare species
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